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Clomid Medical Research Studies

Up-to-date List of Clomid Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Clomid Medical Research Studies

Rank Status Study
1 Recruiting Influence of Pharmacogenetic Factors, Paroxetine and Clarithromycin on Pharmacokinetics of Clomiphene
Conditions: Anovulation;   Disorder Due Cytochrome P450 CYP2D6 Variant;   Cytochrome P450 CYP3A Enzyme Deficiency
Interventions: Drug: Clomiphene;   Drug: clomiphene and paroxetine;   Drug: clomiphene and clarithromycin
Outcome Measures: Area under the plasma concentration versus time curve (AUC)of clomiphene;   Peak Plasma Concentration (Cmax)of Clomiphene;   Clearance of Clomiphene;   Metabolomic;   Tmax of clomiphene;   Pharmacogenomics
2 Not yet recruiting Assessing the Efficacy of Clomiphene Citrate in Patients With Azoospermia and Hypoandrogenism
Conditions: Non Obstructive Azoospermia;   Hypogonadism
Interventions: Drug: Clomiphene;   Drug: Placebo
Outcome Measures: Presence of sperm in the ejaculated or in the microsurgical testicular Sperm extraction (microTESE);   Testosterone levels and Bioavailable Testosterone levels
3 Recruiting Clomiphene Citrate Fast-Track Protocol for Fertility Treatment in Women With PCOS
Conditions: Polycystic Ovary Syndrome;   Infertility
Interventions: Drug: Progestin;   Drug: Clomiphene Citrate
Outcome Measures: Clinical pregnancy confirmed by pelvic ultrasound;   Time to first ovulation;   Time to clinical pregnancy;   Live birth
4 Recruiting Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration
Conditions: Hypogonadism;   Opioid-Related Disorders;   Male Infertility
Interventions: Drug: Clomiphene citrate;   Drug: Placebo
Outcome Measures: Serum total testosterone (change from baseline);   Other hormonal profile (change from baseline);   Urine studies (change from baseline);   Semen analysis (sperm count, concentration, motility, morphology: change from baseline);   Questionnaires- self-administered
5 Recruiting Clomiphene Citrate Plus uFSH Versus Aromatase Inhibitor Plus uFSH in Clomiphene Resistant Infertile PCOS Women
Conditions: Polycystic Ovary Syndrome;   Infertility
Interventions: Drug: Aromatase inhibitor (litrezole) plus uFSH arm;   Drug: clomiphene citrate-uFSH arm
Outcome Measures: ovulation rate;   endometrial thickness;   ongoing cycle pregnancy rate
6 Unknown  Tamoxifen Compared With Clomiphene Citrate for Women Who Had Thin Endometrium Women Under Clomiphene in a Previous Cycle
Condition: Infertility
Interventions: Drug: tamoxifen;   Drug: clomiphene citrate
Outcome Measures: Pregnancy rate;   delivery rate;   endometrium thickness;   percentage of ovulation;   number of follicles
7 Recruiting Luteal Phase Versus Follicular Phase Administration of Clomiphene Citrate in PCOS, A Randomized Controlled Trial
Condition: PCOS
Intervention: Drug: Clomiphene Citrate
Outcome Measures: the total number of follicles, number of follicles > 14 mm in diameter, number of follicles > 18 mm in diameter.;   endometrial thickness
8 Recruiting Clomid in Men With Low Testosterone With and Without Prior Treatment
Condition: Hypogonadism, Male
Intervention: Drug: Clomiphene
Outcome Measures: Total serum testosterone;   Bioavailable testosterone;   Serum sex hormone binding globulin (SHBG)level
9 Unknown  Induction of Ovulation With Raloxifene or Clomiphene Citrate in Polycystic Ovarian Syndrome
Condition: Polycystic Ovary Syndrome
Interventions: Drug: clomiphene citrate;   Drug: raloxifene
Outcome Measures: Ultrasound sign of ovulation;   endometrial biopsy compatible with the +/- 3days of the cycle;   Serum levels of Progesterone
10 Not yet recruiting Ovulation Induction in Women With Clomiphene Citrate Resistant PCOS
Conditions: Polycystic Ovary Syndrome;   Infertility
Interventions: Drug: induction of ovulation using letrozole-pioglitazone-metformin;   Drug: induction of ovulation using clomiphene citrate-pioglitazone-metformin;   Radiation: transvaginal ultrasound;   Other: body mass index (BMI) calculation;   Other: day 3: follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH), total testosterone;   Other: pretreatment blood urea and serum creatinine;   Other: serum estradiol (E2) on day 12;   Other: serum progesterone on day 21;   Other: blood urea and serum creatinine every month
Outcome Measures: ovulation rate;   number of follicles>18mm.;   endometrial thickness;   pregnancy rate
11 Not yet recruiting Assessment of Drug-Drug Interactions of Androxal With Cytochrome P450 Isoenyzmes in Healthy Males
Condition: Drug-drug Interaction
Interventions: Drug: Androxal;   Drug: Placebo
Outcome Measure: Drug-Drug Interaction
12 Recruiting Effect of Progestin-Induced Withdrawal Bleed on Ovulation Induction Cycles With Clomiphene Citrate
Conditions: Polycystic Ovary Syndrome;   Infertility
Intervention: Drug: Progestin
Outcome Measures: Clinical pregnancy rate per ovulation;   cumulative pregnancy rate;   ovulation rate;   ongoing pregnancy rate;   miscarriage rate;   multiple pregnancy rate;   endometrial thickness
13 Not yet recruiting Study to Evaluate the Effect of Food Upon the Pharmacokinetics of Androxal
Condition: Normal Volunteers
Intervention: Drug: Androxal 25 mg Capsules
Outcome Measure: • Cmax of a single dose of 25 mg of Androxal in male subjects in the fed state and fasted state.
14 Recruiting Ovulation Induction With Clomiphene Citrate and Dexamethasone
Condition: Infertility
Interventions: Drug: Placebo;   Drug: Dexamethasone
Outcome Measures: Pregnancy;   Clinical pregnancy
15 Unknown  Hypogonadism in Young Men With Type 2 Diabetes
Conditions: Hypogonadotropic Hypogonadism;   Type 2 Diabetes
Interventions: Drug: testosterone;   Drug: clomiphene;   Drug: placebo
Outcome Measures: insulin resistance;   inflammation;   body composition;   sexual function and spermatogenesis
16 Recruiting Metformin for the Treatment of Unexplained Hypospermatogenesis
Condition: Infertility
Interventions: Drug: Metformin;   Drug: Clomiphene citrate
Outcome Measures: sperm count;   abnormal forms of spermatozoa
17 Unknown  Letrozole Versus Clomifene Citrate for Ovulation Induction
Conditions: Infertility;   Polycystic Ovarian Syndrome
Interventions: Drug: Letrozole;   Drug: Clomifene citrate
Outcome Measures: Pregnancy rate;   1. Ovulation rate 2. Number of growing and mature follicles during treatment 3. Miscarriage rate 4. Live-birth rate 5. Multiple pregnancy rate 6. Endometrial thickness
18 Recruiting Evaluation of Pharmacokinetic and Safety Profile of Androxal in Male Subjects With Impaired Renal Function
Condition: Secondary Hypogonadism
Intervention: Drug: Androxal 25 mg
Outcome Measure: Pharmacokinetic parameters
19 Recruiting Efficacy Study Comparing the Effect of Clomiphencitrate to an Antagonist Protocol
Conditions: Female Infertility;   Ovarian Insufficiency
Interventions: Drug: Serophene High Dose;   Drug: Serophene Low Dose;   Drug: Placebo High Dose;   Drug: Placebo Low dose
Outcome Measures: number of collected oocytes;   Implantation rate
20 Recruiting Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS
Condition: Anovulatory Infertility Related to Polycystic Ovary Syndrome
Intervention: Drug: Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
Outcome Measures: Multiple pregnancy rate;   Ovulation rate;   Pregnancy rate;   Abortion rate;   Live-birth rate;   Adverse-events

These studies may lead to new treatments and are adding insight into Clomid etiology and treatment.

A major focus of Clomid research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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