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Clonidine Medical Research Studies

Up-to-date List of Clonidine Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Clonidine Medical Research Studies

Rank Status Study
1 Not yet recruiting Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia
Condition: Encephalopathy, Hypoxic-Ischemic
Intervention: Drug: Clonidine (Duraclon®)
Outcome Measures: Maximum-tolerated dose of Clonidine;   Clonidine Plasma levels;   Time to onset of shivering after Clonidine;   shivering
2 Not yet recruiting The Effect of Clonidine-enhanced Sedation on Delirium in Ventilated Critically Ill Patients
Condition: Delirium
Interventions: Drug: Clonidine;   Drug: SodiumChloride
Outcome Measures: CAM-ICU (Confusion Assessment Method for the Intesive Care Unit);   Signs of agitation;   Opiate use;   Sedative use;   Anti-psychotic use;   Ventilation free days;   Sedation free days
3 Not yet recruiting Comparison of Epidural Fentanyl and Clonidine for Breakthrough Pain
Condition: Labor Pain
Interventions: Drug: Clonidine or Fentanyl;   Drug: Clonidine or fentanyl
Outcome Measures: Pain Score on a VAS scale;   Maternal blood pressure;   Maternal heart rate;   Neonatal Apgar score;   Number of spontaneous vaginal deliveries
4 Recruiting A Comparison of Ropivacaine Alone Versus Combination of Dexamethasone and Clonidine for Block
Condition: Upper Extremity Fracture
Interventions: Drug: Ropivacaine;   Drug: Ropivacaine and dexamethasone;   Drug: Ropivacaine, dexamethasone, Clonidine;   Drug: Ropivacaine and Clonidine
Outcome Measures: Duration of the supraclavicular block;   Postoperative analgesia
5 Recruiting Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia
Conditions: Cannabis Dependence;   Marijuana Dependence
Interventions: Drug: Dronabinol;   Drug: Clonidine;   Drug: Placebo
Outcome Measures: Change from baseline in cannabis use at 10 weeks;   Change in withdrawal symptoms from baseline at 10 weeks;   Change from baseline in cannabis use at 14 weeks;   Change in withdrawal symptoms from baseline at 14 weeks
6 Unknown  Use of Transdermal Clonidine in Trauma Patients
Condition: Delirium
Interventions: Drug: Clonidine;   Drug: Placebo
Outcome Measures: Duration of mechanical ventilation following administration of the first dose of Clonidine or placebo;   Incidence and duration in hours of delirium currently used;   Time to pass first SBT following administration of the first dose of Clonidine or placebo;   Mean incidence and duration of delirium
7 Recruiting Effectiveness of Perineural Clonidine as an Adjuvant With Ropivacaine for Popliteal Nerve Block in Patients Undergoing Foot and Ankle Surgery
Condition: Pain
Interventions: Drug: Clonidine;   Drug: ropivacaine
Outcome Measures: Compare the onset of sensory and motor block between the control group and the control group;   Compare the duration of sensory and motor block between the control group and the control group;   Compare the mean VAS scores at 24 hours post procecure to determine the effectiveness of perineural Clonidine on duration of postoperative analgesia;   Compare the number of subjects taking postoperative opioids to determine the effect of perineural Clonidine versus placebo;   Compare the subjects mean blood pressure effect of perineural Clonidine versus placebo;   number of subjects in each group requiring sedation;   Determine the effect of perineural Clonidine versus placebo on time to discharge;   Determine the effect of perineural Clonidine versus placebo on postoperative time to first analgesic intake;   Compare the mean VAS scores at 24 hours post procedure to determine the patient satisfaction of perineural Clonidine on duration of postoperative analgesia
8 Recruiting Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients
Conditions: Hot Flashes;   Breast Cancer
Interventions: Drug: solifenacin;   Drug: Clonidine
Outcome Measures: hot flash composite and frequency scores (daily diary);   number of clinician-rated adverse events;   daily functioning (Hot Flash-Related Daily Interference score);   sleep (Insomnia Severity Index);   quality of life (Illness Cognition Questionnaire, SF-12)
9 Recruiting Efficacy of Clonidine and Propranolol in Dentistry (AAA)
Condition: Anxiety
Interventions: Drug: Clonidine;   Drug: Propranolol;   Drug: Placebo
Outcome Measures: Change from baseline in modified dental anxiety scale(MDAS)and vital signs (blood pressure, heart rate, respiratory rate, oxygen saturation) until four hours post treatment;   Changes in Verbal Numerical Rating Scale (VNRS) at three, six, and twenty-four hours post treatment
10 Unknown  Neonatal Spinal Anesthesia: Effects of the Addition of Clonidine
Conditions: Spinal Anesthesia;   Neonates
Intervention: Drug: Clonidine
Outcome Measures: number of "rescue" general anesthesia;   apnea and desaturation occurrence;   duration of spinal anesthesia
11 Recruiting The Addition of Clonidine to 0.2% Ropivacaine for Wound Instillation After Minor Lower Abdominal Surgery in Children
Conditions: Hernia, Inguinal;   Hydrocele
Intervention: Drug: Clonidine
Outcome Measures: Time to first analgesia after procedure;   continuous pain scores (modified Children's Hospital of Eastern Ontario Pain Score [mCHEOPS], modified Wong-Baker Faces);   sedation scores;   emergence delirium score (Pediatric Anesthesia Emergence Delirium [PAED]);   total analgesics consumed;   total sedation consumed
12 Recruiting Assessment of the Effect of Clonidine for Cataract Surgery
Conditions: Pain;   Arrythmia
Interventions: Drug: Clonidine;   Drug: placebo
Outcome Measures: intensity of pain;   intraocular pressure
13 Recruiting Added Value of Local Clonidine for Spine Postoperative Pain Control, in Addition to Bupivacaine
Condition: Post-operative Pain
Interventions: Drug: Bupivacaine;   Drug: Clonidine
Outcome Measures: Mean Area under curve;   Area under Curve (AUC) of pain;   Daily rescue opiates consumption;   Global subjective patient satisfaction of post-operative wound pain control
14 Not yet recruiting Oral Clonidine & Gabapentin: Improving Recovery and Pain Management After Outpatient With Major Orthopedic Surgery
Conditions: Shoulder Arthroscopy;   Knee Arthroscopy
Interventions: Drug: Sugar pill;   Drug: Gabapentin;   Drug: Clonidine
Outcome Measures: Postoperative Pain using a Verbal Rating Scale (VRS);   Opioid consumption obtained from the recorded data;   postoperative nausea and vomiting using a Verbal Rating Scale;   return to normal activities of daily living using follow up questionnaires;   Patient satisfaction using a verbal rating scale from 0 to 100
15 Recruiting Clonidine for Relapse Prevention in Buprenorphine-Maintenance Patients
Condition: Opioid-Related Disorders
Interventions: Drug: Clonidine;   Drug: Placebo
Outcome Measures: Opiate-negative urine screens;   HIV risk behaviors;   Craving
16 Unknown  Clonidine in Femoral Nerve Block Surgery in Children
Condition: Other Reconstructive Surgery
Interventions: Drug: Ropivacaine;   Drug: Clonidine
Outcome Measures: Pain;   Heart rate;   Blood pressure;   Oxygen saturation
17 Recruiting The Oslo Study of Clonidine in Elderly Patients With Delirium
Condition: Delirium
Interventions: Drug: Clonidine;   Drug: Placebo
Outcome Measures: MDAS (Memorial delirium assessment scale);   Time-to-first delirium;   Incidence of "full-scale" delirium;   Severity of delirium;   Delirium subtype;   The use of "rescue medication";   Length of hospital stay;   Patient distress;   Side effects of Clonidine;   Pharmacokinetic response to Clonidine;   Pharmacodynamic response to Clonidine;   Biomarkers;   Institutionalization;   Survival;   Cognitive function/ independence
18 Recruiting The Value of Adding Either Meperdine or Fentanyl to Clonidine-bupivacaine
Condition: Amputation Stumps
Interventions: Drug: Meperdine;   Drug: Fentanyl
Outcome Measures: the hemodynamic effects .;   the analgesic efficacy.
19 Recruiting Efficacy and Safety Study of Clonidine Lauriad® to Treat Oral Mucositis
Condition: Oral Mucositis
Interventions: Drug: Clonidine Lauriad® 50µg;   Drug: Clonidine Lauriad® 100µg;   Drug: Placebo Lauriad®
Outcome Measures: Percentage of patients with an oral mucositis score≥ 3 using the WHO scale at cumulative radiation dose of 50 Gy;   Percentage of patients with an oral mucositis score≥ 3 using the WHO scale at cumulative radiation doses of 40 Gy and 60 Gy
20 Recruiting Safety and Efficacy Study of Clonidine Hydrochloride Topical Gel, 0.1% in the Treatment of Pain Associated With Diabetic Neuropathy
Conditions: Painful Diabetic Neuropathy;   Diabetic Neuropathy;   Neuropathy
Intervention: Drug: Clonidine Gel 0.1%
Outcome Measures: Change in average pain score over time.;   Mean daily average pain intensity Numeric Pain Rating Scale scores over time.;   Mean daily worst pain intensity Numeric Pain Rating Scale scores

These studies may lead to new treatments and are adding insight into Clonidine etiology and treatment.

A major focus of Clonidine research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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