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Clozaril Medical Research Studies

Up-to-date List of Clozaril Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Clozaril Medical Research Studies

Rank Status Study
1 Recruiting Clozapine Versus Amisulpride in Treatment-resistant Schizophrenia Patients
Conditions: Schizophrenia;   Treatment Resistant Disorders
Interventions: Drug: Clozapine;   Drug: Amisulpride;   Drug: Clozapine+Amisulpride
Outcome Measures: Change from baseline in Positive and Negative Syndrome Scale (PANSS);   Change from baseline in Clinical Global Impression - Severity (CGI-S);   Change from baseline in Beck Depression Inventory (BDI);   Change from baseline in Beck Anxiety Inventory (BAI);   Change from baseline in Schizophrenia Quality of Life Scale (SQLS);   Change from baseline in Simpson-Angus Scale (SAS);   Change from baseline in Clozapine Adverse Effects Inventory (CAEI)
2 Not yet recruiting Clozapine Plasma Levels and the Relationship to the Genetic Polymorphism in Shizophrenic Patients
Condition: Schizophrenia
Intervention: Drug: Clozapine
Outcome Measures: Clozapine steady state plasma level;   Polymorphism of CYP1A2, CYP3A4, CYP3A5 and CYP2D6 in clinically stable schizophrenic adult patients
3 Recruiting Clozapine for Cannabis Use in Schizophrenia
Conditions: Schizophrenia;   Cannabis Abuse;   Cannabis Dependence;   Dual Diagnosis
Interventions: Drug: Clozapine;   Drug: Risperidone
Outcome Measures: Intensity of cannabis use;   Frequency of cannabis use;   Symptoms of Schizophrenia;   Quality of Life;   Neuropsychological functioning;   Reward responsiveness
4 Recruiting F-18 Altanserin PET Study of Patients Receiving Clozapine
Conditions: Schizophrenia;   Schizoaffective Disorder
Intervention: Drug: clozapine
Outcome Measures: pharmacodynamics of F-18 artanserin;   serum level of clozapine and metabolites
5 Recruiting Treating Clozapine-induced Sinustachycardia With Bisoprolol
Condition: Clozapine-induced Sinustachycardia
Interventions: Drug: Bisoprolol;   Drug: Placebo
Outcome Measures: Heart rate variability;   QTc, T-wave morphology and other ECG markers;   Hamilton-Anxiety scale;   Salivation rate;   Orthostatic blood pressure;   WHO-QoL;   Nocturnal Hypersalivation Rating Scale (NHRS).
6 Recruiting Relationship Between Neurotransmitter Receptor Polymorphisms, Plasma Concentrations and Clinical Response to Clozapine
Condition: Schizophrenia
Intervention:
Outcome Measures: Brief Psychiatric Rating Scale;   Scale for the Assessment of Positive Symptoms;   Scale for the assessment of Negative symptoms;   Calgary Depression Scale;   Abnormal Involuntary Movement Scale;   Barnes Akathisia Scale
7 Unknown  The Treatment of 2 Chinese Medicines in Clozapine-induced Hypersalivation in Schizophrenia
Conditions: Schizophrenia;   Clozapine;   Hypersalivation;   Traditional Chinese Medicine
Interventions: Drug: Suo Quan Wan, Wu Lin San;   Drug: Placebo
Outcome Measure:
8 Unknown  Association of Multiple Genetic Polymorphisms With Clozapine-Associated Metabolic Change in Schizophrenia
Conditions: Schizophrenia;   Metabolic Syndrome;   Genetic Polymorphism
Intervention:
Outcome Measure: The associations between multiplegenetic polymorphisms (HTR2C,leptin,adrenergic receptor,PPAR,GNB3) and the metabolic side effects (weight,glucose,lipid,BP,metabolic syndrome)
9 Not yet recruiting Minocycline Augmentation to Clozapine
Conditions: Schizophrenia;   Schizoaffective Disorder
Interventions: Drug: Minocycline;   Drug: Sugar Pill
Outcome Measures: Positive symptoms of schizophrenia/schizoaffective disorder;   Negative symptoms of schizophrenia/schizoaffective disorder;   Cognitive symptoms of schizophrenia/schizoaffective disorder;   Perceived quality of life and general well being;   Social, occupational, and psychological functioning;   Number of patients with adverse events;   Markers of inflammation, including C-Reactive Protein
10 Unknown  Effects of Adjunctive Metformin on Metabolic Profiles in Clozapine-treated Schizophrenic Patients
Conditions: Obesity;   Metabolic Syndrome;   Schizophrenia
Interventions: Drug: Metformin;   Drug: placebo
Outcome Measures: body weight change;   metabolic features
11 Unknown  Amisulpride Augmentation in Clozapine-unresponsive Schizophrenia
Condition: Schizophrenia
Interventions: Drug: Amisulpride;   Drug: placebo
Outcome Measures: Total score on the Positive and Negative Syndrome Scale;   Social and Occupational Functioning Assessment Scale;   Calgary Depression Rating Scale for Schizophrenia;   Schedule for the Assessment of Insight;   Service Engagement Scale;   Antipsychotic Non-Neurological Side Effects Scale
12 Recruiting Vitamin D for Schizophrenia
Condition: Clozapine Resistant Schizophrenia
Interventions: Drug: Vitamin D3;   Drug: placebo
Outcome Measures: Change in Positive and Negative Syndrome Scale total score;   change in the MATRICS Consensus Cognitive Battery composite score
13 Recruiting Electroconvulsive Therapy (ECT) in Patients With Super Refractory Schizophrenia
Conditions: Refractory Schizophrenia;   Super Refractory Schizophrenia
Interventions: Device: MECTA SPECTRUM 5000Q ECT;   Procedure: Sham ECT
Outcome Measures: PANSS change from baseline;   CGI change from baseline
14 Recruiting The Effect of Metformin on Obesity and Metabolic Disturbance in Patients Taking Clozapine
Condition: Schizophrenia
Interventions: Drug: Metformin;   Drug: Placebo (for metformin)
Outcome Measures: change of weight;   Positive and Negative Symptom Scale(PANSS);   MADRS(montgomery asberg depression rating scale);   Clinical Global Impression-severity(CGI-S);   Clinical Global Impression-improvement(CGI-I);   Beck's Depression Inventory(BDI);   Liverpool University Neuroleptic Side Effect Rating Scale(LUNSERS);   World Health Organization Quality of Life-BREF (WHOQOL-BREF);   Short form(36) Health survey (SF-36);   abdominal fat amount CT;   change of prevalence of metabolic syndrome
15 Unknown  Effectiveness of Pimozide in Augmenting the Effects of Clozapine in the Treatment of Schizophrenia
Conditions: Schizophrenia;   Psychotic Disorders
Interventions: Drug: Pimozide;   Drug: Placebo
Outcome Measures: Positive and Negative Syndrome Scale (PANSS) total score;   Clinical Global Impression of Change (CGIC)
16 Unknown  Metabolic Side-effects for Second-generation Antipsychotics
Condition: Mental Disorders
Intervention:
Outcome Measure:
17 Unknown  Effects of Gene Polymorphisms on Metabolic Features in Clozapine-treated Patients With Schizophrenia
Conditions: Schizophrenia;   Schizoaffective Disorder
Intervention:
Outcome Measure:
18 Recruiting Optimization of Treatment and Management of Schizophrenia in Europe
Conditions: Schizophrenia;   Schizophreniform Disorder;   Schizoaffective Disorder
Interventions: Drug: Amisulpride open label;   Drug: 6-week amisulpride double blind treatment;   Drug: 6-week olanzapine double blind treatment;   Drug: 12-week clozapine open-label treatment;   Behavioral: Psychosocial intervention
Outcome Measures: PANSS;   Sellwood rating scale;   Biological profile;   MRS measures;   SOFAS global functioning;   MRI assessments;   All cause treatment discontinuation;   All cause discontinuation;   Biological markers
19 Recruiting DAAOI-1 Treatment for Treatment-resistant Schizophrenia
Condition: Schizophrenia
Interventions: Drug: DAAOI-1;   Drug: placebo
Outcome Measures: The severity of psychiatric symptoms;   PANSS subscales;   Hamilton Depression Rating Scale (HAMD);   Cognitive function
20 Recruiting Clinical Trial to Evaluate the Efficacy of Treatment vs Discontinuation in a First Episode of Non-affective Psychosis
Condition: Psychosis Nos/Other
Interventions: Drug: Discontinuation antipsychotic treatment;   Drug: Antipsychotic treatment
Outcome Measure: Risk of relapse

These studies may lead to new treatments and are adding insight into Clozaril etiology and treatment.

A major focus of Clozaril research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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