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Colgate Medical Research Studies

Up-to-date List of Colgate Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Colgate Medical Research Studies

Rank Status Study
1 Recruiting Fluorine F 18 Sodium Fluoride PET/CT and Whole Body and Axial MRI in Finding Metastases in Patients With Recurrent Prostate Cancer
Conditions: Recurrent Prostate Cancer;   Stage IV Prostate Cancer
Interventions: Procedure: computed tomography;   Procedure: bone scan;   Procedure: 3-Tesla magnetic resonance imaging;   Procedure: diffusion-weighted magnetic resonance imaging;   Radiation: fluorine F 18 sodium fluoride;   Procedure: positron emission tomography;   Other: laboratory biomarker analysis
Outcome Measures: Percent of patients with negative standard scans and positive on the newer scans;   Percent of eligible patients with negative, indeterminate and positive CT scan/bone scan and targeted X-rays if done;   Proportion of patients with biochemically recurrent PC in whom recurrence in the prostate bed can be visualized using MRI in the absence of detection using CT scan;   Presence of metastatic disease detected using WB/axial MRI and/or fluorine F 18 sodium fluoride PET/CT;   Ability of axial MRI to identify sites of disease;   Ability of WB MRI to identify sites of disease;   Relative contribution of fluorine F 18 sodium fluoride PET/CT;   Relative contribution of MRI
2 Not yet recruiting Fluoride Varnish For Childsmile Nursery School Attenders
Condition: Dental Caries
Interventions: Drug: Duraphat® Fluoride Varnish;   Behavioral: treatment as usual
Outcome Measures: d3mft ( a standard measure of dental health (number of teeth where decay which has penetrated the tooth enamel, plus the number of missing or filled teeth);   d3mfs
3 Recruiting Observational Pilot Study of 18F-Sodium Fluoride (Na18F) Whole Body Positron Emission Tomography (PET) Scans for Imaging Bone
Condition: Bone Scan
Intervention: Other: 18F-Sodium Fluoride (Na18F)
Outcome Measures: Establish the feasibility of using locally produced 18F-Sodium Fluoride for PET bone scans as a substitute for 99mTc MPD;   Demonstrate the safety of 18F-Sodium Fluoride by documentation of adverse events.
4 Recruiting Clinical Effectiveness of Various Professionally Applied Fluoride Prophylaxes in Groups at High Risk
Conditions: White Spot Lesion;   Caries
Intervention: Other: Fluor Protector S
Outcome Measure: the number of caries and white spot lesions in teeth treated with fluoride varnishes comparing to the control group.
5 Recruiting Comparison of 18-F Sodium Fluoride Uptake in Culprit Plaques Between Acute Coronary Syndrome and Stable Angina
Condition: Coronary Artery Diseases
Intervention: Other: 18-F Sodium Fluoride Uptake in Positron emission tomography
Outcome Measures: Standardized 18F-NaF uptake value within the culprit plaque;   The relationship between 18F-NaF uptake value and calcium scores by Multidetector Computed Tomography;   The relationship between 18F-NaF uptake value and plaque types by Multidetector Computed Tomography;   The relationship between 18F-NaF uptake value and biomarkers;   The relationship between 18F-NaF uptake value and invasive imagings
6 Unknown  Triclosan Toothpaste and Third Molar Surgery
Conditions: Dry Socket;   Wound Infection
Interventions: Other: Colgate Total Toothpaste;   Other: Colgate Regular Toothpaste
Outcome Measures: dry socket;   wound infection
7 Not yet recruiting Effectiveness of Dental Caries Arrest Treatment in Primary Teeth Using AgNO3 Followed by NaF Varnish
Condition: Early Childhood Caries
Interventions: Drug: 25% AgNO3 solution followed by 5% NaF varnish;   Drug: 38% SDF solution followed by placebo varnish
Outcome Measure: The hardness of cavity on tooth by probing
8 Recruiting Sodium Fluoride (NaF) Positron Emission Tomography/Computed Tomography (PET/CT) in Patients With Metastatic Castrate-resistant Prostate Cancer (CRPC) With Microtubule Directed Chemo or AR-directed Therapy
Condition: Prostate Cancer
Intervention: Procedure: Sodium Fluoride (NaF) Positron Emission Tomography/Computed Tomography (PET/CT) imaging
Outcome Measures: The repeatability of NaF PET/CT imaging for evaluating bone metastases in patients with metastatic castrate-resistant prostate cancer.;   Evaluate changes on NaF PET/CT images in response to chemotherapy (antimicrotubule directed chemotherapy) or androgen receptor (AR)-directed therapy.;   Prostate Specific Antigen (PSA) response;   Response Evaluation Criteria in Solid Tumors (RECIST) response;   Radiographic progression free survival
9 Unknown  Impact of Fluoride Vanish Application in Dental Prevention for Elderly
Condition: Tooth Decay
Intervention: Drug: Duraphat
Outcome Measure: incidence of tooth decay at endpoint. Comparison, between the treated and not treated side of the mandibles
10 Recruiting Periodontal Treatment Response in Type II Diabetic Patients
Conditions: Type II Diabetes;   Periodontal Disease
Interventions: Drug: Triclosan containing toothpaste;   Drug: Non-triclosan containing toothpaste
Outcome Measures: Clinical Periodontal Parameters;   Local Inflammatory Markers;   Glycemic Control;   Systemic Inflammatory Markers
11 Recruiting Effect Assessment of Periodontal Prophylaxis on Rheumatoid Arthritis Activity.
Condition: Patients With Anti-CCP Positive Early Rheumatoid Arthritis
Intervention: Other: Periodontal prophylaxis
Outcome Measures: Periodontal prophylaxis;   Bacterial identification;   Rate of anti-citrulline and anti P. gingivalis antibodies
12 Not yet recruiting Clinical Trial Proximal Caries Infiltration and Detection
Condition: Caries
Interventions: Device: Icon;   Device: fluoride varnish
Outcome Measures: Caries arrest after Icon treatment evaluated by bitewing radiographs;   quantified results from primary endpoint may also visualized by SFE
13 Not yet recruiting 18F-NaF PET Imaging for Bone Scintigraphy
Condition: Bone Metastases From Breast or Prostate Cancer
Interventions: Procedure: NaF PET/CT Imaging;   Procedure: 99mTc-medronate whole body bone scan with SPECT;   Drug: 18F-NaF (185-370 MBq)
Outcome Measures: Accuracy, sensitivity, and specificity of 18F-Sodium Fluoride (18F-NaF) Positron Emission Tomography compared to 99mTc-Methylene Diphosphonate (MDP) bone SPECT imaging for detection of bone metastasis.;   The secondary outcome is to monitor the short-term side-effects following 18F-NaF PET/CT to assess for adverse drug reactions
14 Recruiting A Clinical Trial to Test the Effect of Experimental Mouth Rinse on Gum Disease
Condition: Gingivitis
Interventions: Other: Listerine Advance Gum Defense;   Other: Mouth rinse containing Chlorhexidine;   Other: Mouth rinse containing 5% Hydroalcohol
Outcome Measures: Whole Mouth Mean Bleeding Index (BI) at 4 weeks;   Whole Mouth Mean Bleeding Index (BI) at 1 week;   Whole-mouth Mean Modified Gingival Index (MGI);   Turesky Modification of the Quigley Hein Plaque Index (PI);   Extrinsic Stain
15 Recruiting F18PET/CT Versus TC-MDP Scanning to Detect Bone Mets
Condition: Bone Metastases
Intervention: Device: Bone Scan: F18-Fluoride PET/CT or TC-MDP
Outcome Measure: Analysis of the diagnostic performance of [18F]NaF fluoride PET/CT scanning
16 Recruiting Cardiovascular Molecular Calcification Assessed by 18F-NaF PET CT
Conditions: Cardiovascular Disease;   Atherosclerosis;   Angina Pectoris
Intervention:
Outcome Measures: Standardized uptake value (SUV) of 18F-NaF;   Target to background ratio (TBR) of 18F-NaF;   Standardized uptake value (SUV) of 18F-Fluorodeoxyglucose (18F-FDG);   Target to background ratio (TBR) of 18F-FDG;   Correlation between the TBR of 18F-NaF/18F-FDG and traditional cardiovascular risk factors.;   Correlation between the TBR of 18F-NaF/18F-FDG and blood markers of atherosclerosis.;   Correlations between 18F-NaF TBR, 18F-FDG TBR, and CT calcification scoring;   Correlation between 18F-NaF / 18F-FDG uptake and 18F-FDG uptake in the brain;   Correlation between 18F-NaF TBR and 18F-NaF TBR two years after the baseline scan.;   Correlation between 18F-FDG TBR and 18F-FDG TBR two years after the baseline scan.;   Correlation between the TBR of 18F-NaF/18F-FDG and HeartSCORE;   Correlation between the TBR of 18F-NaF/18F-FDG and Framingham Risk Score;   Correlation between 18F-NaF / 18F-FDG uptake and 18F-NaF / 18F-FDG uptake in the vertebral body;   Arterial Calcification Score
17 Recruiting A Study of DKN-01 and Lenalidomide/Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma
Condition: Multiple Myeloma
Interventions: Drug: DKN-01 300 mg;   Drug: DKN-01 600 mg;   Drug: Standard of Care
Outcome Measures: Fluorine F18 sodium fluoride positron emission tomography (NaF-PET/CT) standard uptake value (SUV);   Fluorine F18 sodium fluoride positron emission tomography (NaF-PET/CT) influx constant (Ki);   F18 fluorodeoxyglucose positron emission tomography (FDG-PET/CT) standard uptake value (SUV);   Number of patients with treatment emergent adverse events;   Overall response rate (ORR);   Progression free survival (PFS);   Duration of response;   Overall survival;   Pharmacokinetics: area under the concentration - time curve (AUC) of a single dose of DKN-01;   Pharmacokinetics: maximum plasma concentration (Cmax) of a single dose of DKN-01;   Pharmacokinetics: trough DKN-01 concentrations on Cycle 2 and Cycle 3
18 Not yet recruiting Caries Prevention Products & Dentinal Hypersensitivity
Condition: Hypersensitivity
Intervention:
Outcome Measure: Change in Dentinal Hypersensitivity
19 Recruiting Dental Office Prevention Strategies for Children
Condition: Dental Plaque
Intervention: Procedure: Single cleansing procedure of 10% Povidone Iodine
Outcome Measures: dental plaque levels;   dental plaque composition
20 Recruiting Metabolic Imaging in Carotid Atherosclerosis
Conditions: Atherosclerosis;   Stroke
Interventions: Other: USPIO (ferumoxytol)-enhanced MRI scan;   Radiation: 18f-Fluoride PET/CT scan;   Radiation: 18F-Flurodeoxyglucose PET/CT scan
Outcome Measures: The Standardized Uptake Value (SUV) for 18F-Fluoride of the ipsilateral carotid artery;   The SUV of 18F-Flurodeoxyglucose on PET/CT of the ipsilateral carotid artery;   A correlation between the ipsilateral carotid SUV of 18F-Flurodeoxyglucose and tissue markers of inflammation and apoptosis.;   A correlation between ipsilateral carotid SUV of 18F-Fluoride and the gene expression characteristics of excised plaque.;   A correlation between the ipsilateral carotid SUV of 18F-Fluoride and tissue markers of apoptosis and calcification.;   The presence or absence of USPIO (ultra-small superparamagnetic particles of iron oxide) uptake on MRI (magnetic resonance image) within the ipsilateral carotid artery compared to its contralateral partner.;   A correlation between the ipsilateral carotid USPIO uptake and tissue markers of inflammation and apoptosis.;   A correlation between the ipsilateral carotid USPIO uptake and gene expression characteristics of excised atheroma.;   The ipsilateral carotid radioactivity, arterial blood radioactivity and whole blood fluoride concentration measured over time

These studies may lead to new treatments and are adding insight into Colgate etiology and treatment.

A major focus of Colgate research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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