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Combigan Medical Research Studies

Up-to-date List of Combigan Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Combigan Medical Research Studies

Rank Status Study
1 Unknown  Effect of Xalacom® (Latanoprost/Timolol) and Combigan® (Brimonidine/Timolol) Fixed Combination on Intraocular Pressure and Ocular Blood Flow in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
Conditions: Retina;   Ocular Physiology
Interventions: Drug: latanoprost 0.005% + timolol 0,5% fixed combination;   Drug: brimonidine 0,2% + timolol 0,5% fixed combination
Outcome Measures: Optic disc blood flow measured with laser Doppler flowmeter (rel units);   Intraocular pressure (mmHg);   Retrobulbar flow velocities as measured with color Doppler imaging (cm/s);   Mean defect of visual field measured with automated perimetry (dB);   Corneal thickness as measured with pachymetry (µm)
2 Unknown  Efficacy and Safety Study of Combigan and 0.5% Timoptic in Normal Tension Glaucoma
Condition: Normal Tension Glaucoma
Interventions: Drug: Brimonidine/Timolol mixed combination;   Drug: Timolol
Outcome Measure: Change from baseline in intraocular pressure at 12 weeks
3 Unknown  Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG)
Condition: Glaucoma
Interventions: Drug: Cosopt;   Drug: Combigan
Outcome Measure: Change in retinal blood flow with increase in perfusion pressure due to posture change
4 Recruiting Safety and Efficacy of Triple Combination Therapy in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension
Conditions: Glaucoma, Open-Angle;   Ocular Hypertension
Interventions: Drug: bimatoprost/brimonidine tartrate/timolol ophthalmic solution (Triple Combination Therapy);   Drug: Fixed Combination 0.2% brimonidine tartrate/0.5% timolol ophthalmic solution
Outcome Measures: Intraocular Pressure (IOP);   IOP

These studies may lead to new treatments and are adding insight into Combigan etiology and treatment.

A major focus of Combigan research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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