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Compartment Syndrome Medical Research Studies

Up-to-date List of Compartment Syndrome Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Compartment Syndrome Medical Research Studies

Rank Status Study
1 Unknown  The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome
Condition: Acute Compartment Syndrome
Intervention: Device: Near infrared spectroscopy (NIRS)
Outcome Measures: Incidence of acute compartment syndrome (ACS);   Intracompartmental pressure (ICP)
2 Unknown  Assessment of Near Infrared Spectroscopy as a Diagnostic Tool in Acute Compartment Syndrome
Condition: Compartment Syndrome
Intervention: Device: near-infrared spectroscopy
Outcome Measure: NIRS values in lower leg extremity injury
3 Recruiting Predicting Acute Compartment Syndrome (PACS)
Condition: Acute Compartment Syndrome
Intervention: Other: Continuous tissue perfusion monitoring by near-infrared spectroscopy (NIRS) and intramuscular pressure (IMP)
Outcome Measures: Retrospective assessment of the likelihood of Compartment Syndrome;   Clinician agreement in retrospective assessments of the likelihood of ACS.
4 Recruiting Phase I, Arteriocyte Magellan MAR01 Therapy - Compartment Syndrome and Battlefield Trauma
Condition: Compartment Syndrome
Intervention: Device: Magellan®
Outcome Measures: Time to treatment failure or death;   Perfusion and quality of life measurements
5 Unknown  Study of New Catheter & Pressure Monitor System to Help Prevent Compartment Syndrome From Developing in the Injured Leg
Condition: Compartment Syndrome
Interventions: Device: Compartment Monitoring System (CMS);   Device: Compartment Monitoring System with Active Fluid Removal;   Device: Compartment Monitoring System without fluid removal
Outcome Measures: To determine if use of Twin Star catheter with active fluid removal reduces muscle compartment pressure vs Twin Star catheter without fluid removal by comparing the randomized groups. Success will be defined by a p-value less than 0.05 (two-sided).;   Compares the treatment and control groups on change in perfusion pressure (defined as diastolic blood pressure minus IMP) over time. The randomized groups will be compared with a two-sided p-value less than 0.05 defining success.
6 Unknown  Laparotomy Versus Percutaneous Puncture in Patients With Abdominal Compartment Syndrome During Acute Pancreatitis
Conditions: Mortality;   Acute Pancreatitis
Interventions: Procedure: Decompressive laparotomy with temporary abdominal closure;   Procedure: Percutaneous puncture with placement of abdominal catheter
Outcome Measures: Mortality rate during the hospital stay for patients with abdominal Compartment Syndrome during acute pancreatitis.;   duration time of organ failure;   development of a new organ failure;   number of infectious complications,;   needs for necrosectomy,;   intensive care stay;   total hospital stay
7 Not yet recruiting The Effect of Different Types of Temporary Abdominal Closure on Intra Abdominal Hypertension.
Conditions: Intra Abdominal Hypertension;   Abdominal Compartment Syndrome
Outcome Measures: Intra abdominal hypertension;   Abdominal compartment syndrome
8 Recruiting The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function
Conditions: Critically Ill;   Intra-Abdominal Hypertension;   Abdominal Compartment Syndrome;   Acute Kidney Injury
Interventions: Procedure: CVVH;   Procedure: ultrafiltration;   Procedure: ultrafiltration control group
Outcome Measures: Change in IAP in patients receiving fluid removal during CVVH vs patients receiving CVVH without net fluid removal after 24 and 48h of CVVH treatment;   Difference between CVVH with fluid removal and CVVH without fluid removal;   Difference between both groups in terms of daily fluid balance;   The relationship between cumulative fluid balance at the start of each day of CVVH and the fluid balance achieved after 24h of CVVH with fluid removal;   Difference between both groups regarding recovery of renal function, need for RRT at discharge from the ICU and from the hospital;   Difference between both groups regarding mortality (28d, ICU and hospital) and ICU and hospital length of stay
9 Unknown  The Influence of Furosemide on Fluid Balance and Intra-abdominal Pressure in Critically Ill Patients
Condition: Intra-Abdominal Hypertension
Intervention: Drug: furosemide
Outcome Measures: intra-abdominal pressure;   serum creatinine;   need for renal replacement therapy;   ICU mortality;   acid-base status;   hospital and 28d mortality;   duration of mechanical ventilation;   ICU length of stay;   vasopressor dose;   fluid balance;   SOFA score
10 Not yet recruiting Double Blinded, Randomized Clinical Trial of the Twin Star ECSPRESS Monitoring System for the Reduction of the Incidence of Fasciotomy
Condition: Compartment Syndrome
Intervention: Device: ECSPRESS catheter with active vacuum
Outcome Measures: Incidence of fasciotomies;   Area under the curve (AUC) for time-pressure
11 Not yet recruiting Study of Use of Dexmedetomidine for Regional Anesthesia
Conditions: Patients Scheduled for Upper Extremity Surgeries (Vascular Occlusion Syndrome, Acute Compartment Syndrome, Capral Tunnell Syndrome Etc.);   Will Participate in the Study.;   Focus of the Study is to Determine:;   the Optimal Dose of Dexmedetomidine Added to Lidocaine;   for Infra- and Supra-clavicular Brachial Plexus Block.
Intervention: Drug: Precedex injection
Outcome Measure: Pain scores on Visual Analog Scale will be measured
12 Recruiting Intra-abdominal Pressure Monitoring in Patients With Open Abdomen Undergoing Early Closure
Condition: Open Wound of Other and Unspecified Parts of Abdomen
Intervention: Device: AbViser abdominal compartment pressure measuring device
Outcome Measures: Intra-abdominal pressure (IAP)  Measurements;   Length of time in critical care unit
13 Recruiting A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Proximal Tibial Fractures
Condition: Tibial Fractures
Interventions: Device: reamed, interlocking intramedullary nail;   Device: locking periarticular plate
Outcome Measures: SF-12v2;   EQ-5D;   SMFA;   Knee Society Score;   Clinical Assessment;   Re-operation (secondary procedures);   nonunion;   superficial infection rates (wound only);   deep infection (bone implant interface);   compartment syndrome;   malunion (>5 degrees varus/valgus);   >5 degrees anterior or posterior angulation;   >10 malrotation degrees, and >1cm shortening);   knee range of motion
14 Unknown  Vitamin C for Severe Thermal Injuries
Condition: Severe Thermal Injury, Greater Than 20% TBSA
Interventions: Drug: High Dose Ascorbic Acid;   Drug: Placebo
Outcome Measures: Fluid Volume Requirements during the resuscitative phase after severe burn;   Days of Ventilator Support Required;   Incidence of Abdominal Compartment Syndrome;   Complication and infection rates in the Vitamin C group;   Incidence of Renal Failure
15 Recruiting Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms
Conditions: Abdominal Aortic Aneurysms;   Blood Transfusion Requirements
Intervention: Drug: Tranexamic Acid administration
Outcome Measures: Transfusion requirement;   Number of ruptured abdominal aortic aneurysms requiring open laparotomy compared to endovascular stunting;   All cause 28 day mortality;   Blood transfusion requirement;   Number of blood transfusions;   Incidence of Transfusion Related Acute Lung Injury (TRALI);   Incidence of Transfusion Related Reactions;   Mechanical ventilator days;   Length of stay in ICU;   Length of stay in hospital;   Incidence of intrabdominal hypertension;   Incidence of Abdominal Compartment Syndrome (ACS);   Requirement of either continuous or intermittent renal replacement therapy (dialysis);   Cardiac morbidity;   Multiorgan Dysfunction Score
16 Recruiting Arm Pump in Motorcross Training
Conditions: Healthy Individuals;   Patients With Arm Pump
Outcome Measures: motor ergonomics;   hand grip strength
17 Recruiting Safety of Spinal Anesthesia in Patients With Tibial Shaft Fracture
Condition: Tibial Fracture
Interventions: Procedure: General anesthesia;   Procedure: Spinal anesthesia
Outcome Measures: Compartment pressure;   INVOS values after surgery
18 Not yet recruiting Reliability of Sensor Spacing for NIRS in Traumatic Tibia Fractures
Conditions: Orthopedic Disorders;   Tibial Fractures
Outcome Measures: NIRS measurements as compared to clinical findings;   Accuracy of NIRS measurements compared to Intracompartmental pressure (ICP) measurements;   Correlation between NIRS measurements between injured and uninjured extremity
19 Recruiting Use of Hypertonic Saline After Damage Control Laparotomy to Improve Early Primary Fascial Closure
Condition: Open Abdomen After Damage Control Laparotomy
Interventions: Procedure: Primary Fascial Closure;   Device: wound vac dressing application
Outcome Measures: Number of participants who achieve primary fascial closure;   number of ICU free days;   number of enterocutaneous fistula;   number of intra abdominal abscess;   number of abdominal wall hernias;   number of anastomotic failure;   number of ventilator free days;   number of hospital free days
20 Recruiting Management of Occult Pneumothoraces in Mechanically Ventilated Patients
Condition: Pneumothorax
Interventions: Procedure: chest drainage;   Other: close clinical observation
Outcome Measures: Outcome Variables: In ventilated patients with small to moderate sized occult PTXs, the rate of respiratory distress will not differ between those treated with chest thoracostomy tubes and those not treated but simply observed;   Observation of small OPTXs in ventilated patients will not increases the rates of Emergency chest drainage, Death, tracheostomy, ARDS, Ventilator associated pneumonia (VAP), or the Abdominal Compartment Syndrome (ACS)

These studies may lead to new treatments and are adding insight into Compartment Syndrome etiology and treatment.

A major focus of Compartment Syndrome research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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