Up-to-date List of Concerta Medical Research Studies
What Research is Being Done?
A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.
Experimental pain intensity measured on a visual analogue scale (0-100); effect of Ritalin on auditory sensitivity, measured by the response to different auditory stimulations; pain intensity (NPS 0-100) in response to thermal stimuli and the measures of the auditory tests.
Relationship between tonic dopamine release (measured by displacement of [11C]-raclopride by oral methylphenidate) and change in processing speed between baseline and after methylphenidate treatment.; Relationship between D2/D3 receptor availability in ventral striatum and prefrontal cortex and neuropsychologic deficits.; Relationship between tonic dopamine release in the ventral striatum and prefrontal cortex with neuropsychologic deficits after TBI.; Relationship between D2/D3 receptor availability and functional connectivity of the prefrontal cortex with nodes of the default mode network.; Relationship between TMS-induced short-interval cortical inhibition of M1 and tonic dopamine release.; Test motivation and reward on and off methylphenidate in TBI patients.
Effect on amygdala and striatum BOLD signal responses to emotional stimuli; Effects on cognitive performance and associated BOLD signal changes in frontal areas; Subjective effects; Neuroendocrine effects; Empathy and social behavior; Physiological effects of methylphenidate, modafinil, and MDMA; Genetic Polymorphisms; Pharmacokinetics of methylphenidate, modafinil, and MDMA
Timed Up and Go time (TUG time); Automatic Postural Response (APR) Latency (in sec); Timed 25 Foot Walk (T25FW in secs); Pittsburgh Sleep Quality Assessment Questionnaire score; Modified Fatigue Index Scale score; Vestibular-Ocular Reflex time (in secs)
Identify abnormalities in prefrontal control neural circuits underlying attention control, motor control, and appetitive control; Characterize effects of methylphenidate and naltrexone on neural circuits in prefrontal cortex associated with attention control, motor control, and appetitive control; Reaction time on the Multi-Source Interference Task; Accuracy on the Multi-Source Interference Task; Reaction time variability on the Multi-Source Interference Task
Frequency of binge episodes/days, as assessed by prospective daily binge diary; Frequency of objective binge episodes and overall illness severity, as assessed by both the Eating Disorder Examination Interview and Questionnaire; Clinician impression of illness severity and improvement, as assessed by the Clinical Global Impression scale; Quality of life, as assessed by the Quality of Life Inventory; Associated features of binge eating as captured by the Dutch Eating Behavior Questionnaire and Binge Eating Scale; Body Mass Index
These studies may lead to new treatments and are adding insight into Concerta etiology and treatment.
A major focus of Concerta research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.