Up-to-date List of Constipation Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Constipation Medical Research Studies

1 Not yet recruiting Innovative Toilet Seat Test for Patients With Symptoms of Constipation and/or Emptying Disorders
Condition: Constipation
Interventions: Device: Experimental toilet seat;   Device: Standard toilet seat
Outcome Measures: Improvement in bowel movement frequency;   Improvement in quality of life
2 Recruiting Lactobacillus Reuteri in Treatment of Functional Abdominal Pain and Chronic Constipation in Children
Conditions: Abdominal Pain;   Constipation - Functional
Interventions: Dietary Supplement: Administration of L.reuteri in children with abdominal pain;   Dietary Supplement: Administration of placebo in children with abdominal pain;   Dietary Supplement: Administration of L.reuteri in children with Constipation;   Dietary Supplement: Administration of placebo in children with Constipation
Outcome Measures: Intensity of abdominal pain;   Severity of chronic Constipation;   Intensity of abdominal pain after treatment;   Severity of chronic Constipation after treatment
3 Recruiting Perineal Self-Acupressure
Conditions: Chronic Constipation;   Constipation;   Hemorrhoids
Interventions: Behavioral: Perineal Self-Acupressure;   Behavioral: Educational Control
Outcome Measures: Patient Assessment of Constipation Quality of Life Questionnaire;   Modified Bowel Function Index and Hemorrhoid Questionnaire;   SF-12
4 Not yet recruiting A Trial of Three Types of Enemas Used to Treat Functional Constipation in Children
Condition: Functional Constipation
Interventions: Drug: Sodium phosphate enema;   Drug: Normal saline enema;   Drug: Mineral oil enema
Outcome Measure: Change in pain scores following administration of enema
5 Unknown  Lubiprostone in Patients With Multiple Sclerosis Associated Constipation
Conditions: Multiple Sclerosis;   Constipation
Interventions: Drug: Lubiprostone;   Drug: Placebo
Outcome Measures: To determine the effect of lubiprostone 24 mcg twice daily on spontaneous bowel movements in patients with MS-associated Constipation;   To determine the safety of lubiprostone based on adverse event (AE) type, frequency, and severity. Hypothesis: AE type, frequency, and severity will be comparable in lubiprostone and placebo treated patients.
6 Recruiting Functional Magnetic Stimulation Enhances Gastrointestinal Motility in Patients With Chronic Constipation
Condition: Constipation
Intervention: Device: Functional Magnetic Stimulation
Outcome Measures: Effectiveness of FMS in accelerating the gastric emptying in patients with non-neurological Constipation after 5-week conditioning protocol;   Effectiveness of FMS in reducing the colonic transit time in patients with non-neurological Constipation after a 5 week conditioning period
7 Recruiting A Study to Evaluate the Effects of a Natural Supplement in Adults With Chronic Functional Constipation
Condition: Constipation
Intervention: Dietary Supplement: Natural Fibre Supplement
Outcome Measures: Number of bowel movements per week;   Stool consistency, as measured by the Bristol Stool Form Scale;   Quality of life as measured by the Quality of Life Questionnaire (PAC-QOL);   Constipation symptoms as measured by PAC-SYM;   Laxative use by subjects with functional Constipation
8 Not yet recruiting Feasibility Study of Oral Naloxone for Treatment of Methadone-induced Constipation
Condition: Constipation
Interventions: Drug: Naloxone;   Drug: Placebo
Outcome Measures: Severity of Constipation symptoms;   Severity of opioid withdrawal symptoms
9 Recruiting MiraLAX Versus Placebo to Prevent Constipation Following Urogynecologic Surgery
Condition: Post Procedural Constipation
Interventions: Drug: MiraLax;   Drug: Placebo;   Drug: Rescue Laxative
Outcome Measures: Time to first postoperative bowel movement;   Other postoperative medication use;   Evaluation of symptoms and quality of life related to Constipation;   Symptoms of Over-Effectiveness;   Evaluation of symptoms and quality of life related to Constipation 6-weeks postoperatively
10 Recruiting Trial on Short-chain Fructooligosaccharides, Microbiota, and Constipation in Adults
Condition: Functional Constipation
Interventions: Dietary Supplement: sc-FOS 2g/day;   Dietary Supplement: sc-FOS 4g/day;   Dietary Supplement: sc-FOS 8g/day;   Dietary Supplement: Placebo
Outcome Measures: Stool frequency (Number of complete bowel movements per day);   Stool consistency (Bristol Stool Scale);   Severity of symptoms (Constipation Scoring System; CSS);   Quality of Life (Patient Assessment of Constipation Quality of Life; PAC-QoL)
11 Recruiting Reflexology for Chronic Constipation
Condition: Chronic Constipation
Intervention: Procedure: Reflexology
Outcome Measures: Change in complete spontaneous bowel movements (CSBM)/week from baseline to 24 weeks;   Increase of at least one CSBM per week from baseline for 9 or more weeks during the 24-week treatment period;   Stool frequency/Week (CSBMs and spontaneous bowel movements (SBMs);   Stool consistency/week using the 7- point Bristol Stool Form Scale, during the 24 weeks of the study period;   Severity of straining using a 5-point ordinal scale (1 indicates not at all; 5 an extreme amount).;   Abdominal discomfort, using a 5-point ordinal scale (1 indicates not at all; 5 an extreme amount);   Severity of bloating, using a 5-point ordinal scale (1 indicates not at all; 5 an extreme amount);   Constipation severity (using a 5-point ordinal scale, with higher scores indicating greater severity);   Constipation relief (based on a 7-point balanced scale, with 1 indicating complete relief, 4 indicating no change, and 7 indicating very severe Constipation);   Satisfaction with the trial results, using a 5-point ordinal scale;   Health related quality of life (using the validated Patient Assessment of Constipation Quality of Life instrument (PAC-QOL);   Treatment side effects
12 Unknown  Effect of Lubiprostone on Methanogenesis and Bowel Function in Chronic Constipation.
Condition: Chronic Constipation, Methanogenesis
Interventions: Drug: Lubiprostone;   Drug: Lubiprostone Control
Outcome Measure: Effect of Lubiprostone in patients with Chronic Constipation
13 Unknown  Multistrain Probiotic for Functional Constipation
Condition: Functional Constipation
Interventions: Dietary Supplement: High dose Multistrain probiotic, 100 billion cfu/day;   Dietary Supplement: Low dose Multistrain probiotic, 15 billion cfu/day
Outcome Measures: Whole gut transit time;   Patient Assessment of Constipation Quality of Life (PAC-QOL);   Wexner Constipation Score (WCS);   Gastrointestinal Symptom Rating Scale (GSRS);   Stool frequency;   Stool consistency;   Fecal probiotic count;   Adverse events
14 Recruiting Effectiveness of Standing Frame on Constipation in Children With Cerebral Palsy
Conditions: Cerebral Palsy;   Quadriplegia;   Diplegia;   Constipation
Intervention: Device: standing-frame
Outcome Measures: bowel evacuation frequency;   Bowel evacuation inductions frequency
15 Recruiting The Efficacy and Safety Study of Electro-acupuncture for Severe Chronic Functional Constipation
Condition: Constipation
Interventions: Device: electro-acupuncture;   Device: sham electro-acupuncture
Outcome Measures: Change of weekly average CSBM from baseline;   The proportion of participants having three or more CSBMs on average per week;   Change of weekly average CSBMs from baseline;   Change of weekly average SBMs from baseline;   Change of average weekly stool consistency assessment from baseline;   Change of average weekly degree of difficulty in defecation from baseline;   PAC-QOL;   incidence of adverse events;   Usage of medicine for Constipation
16 Recruiting Quality of Life in Children and Adolescents With Chronic Functional Constipation: Educational Action Effects
Condition: Chronic Functional Constipation
Intervention: Behavioral: Educational action with focal group
Outcome Measures: The improvement in the quality of life on participants after the intervention;   The improvement in clinical parameters of chronic functional Constipation
17 Recruiting Efficacy of Sacral Nerve Modulation in Severe Refractory Constipation
Condition: Constipation
Intervention: Procedure: sacral nerve modulation
Outcome Measures: Percentage of patients showing a positive response to sacral nerve stimulation at 2 months;   Clinical characteristics, manometry data, Wexner score of responders to stimulation during the temporary stimulation test (period before the permanent implantation);   Clinical characteristics, manometry data, Wexner score of responders to short-term stimulation;   Efficacy of neuromodulation;   Manometry data, Wexner, QoL and EVA scores, time of colonic transit of responders to prolonged stimulation;   To evaluate the investigator opinion about the neuromodulation response, using the patient diary.
18 Recruiting Maintenance Treatment for Children With Constipation
Condition: Constipation
Interventions: Drug: Polyethylene glycol 3350;   Other: Placebo
Outcome Measures: Treatment recovery;   Usage of laxative
19 Unknown  Pilot Study of the Effect of Lactulose on Post Caesarean Section Constipation
Conditions: Constipation;   Abdominal Pain;   Nausea;   Vomiting
Intervention: Drug: Lactulose
Outcome Measures: Time in hours to passage of first stool post Caesarean Section.;   Frequency of abdominal pain between lactulose and non-lactulose groups.;   Frequency of nausea and vomiting between lactulose and non-lactulose groups
20 Not yet recruiting Assessing a Stool Symptom Screener in Patients With Chronic Opioid-Induced Constipation
Condition: Opioid-induced Constipation
Outcome Measure: Semi-structured discussion guide

These studies may lead to new treatments and are adding insight into Constipation etiology and treatment.

A major focus of Constipation research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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