Up-to-date List of Constipation Medical Research Studies
What Research is Being Done?
A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.
Dietary Supplement: Administration of L.reuteri in children with abdominal pain; Dietary Supplement: Administration of placebo in children with abdominal pain; Dietary Supplement: Administration of L.reuteri in children with Constipation; Dietary Supplement: Administration of placebo in children with Constipation
Intensity of abdominal pain; Severity of chronic Constipation; Intensity of abdominal pain after treatment; Severity of chronic Constipation after treatment
To determine the effect of lubiprostone 24 mcg twice daily on spontaneous bowel movements in patients with MS-associated Constipation; To determine the safety of lubiprostone based on adverse event (AE) type, frequency, and severity. Hypothesis: AE type, frequency, and severity will be comparable in lubiprostone and placebo treated patients.
Effectiveness of FMS in accelerating the gastric emptying in patients with non-neurological Constipation after 5-week conditioning protocol; Effectiveness of FMS in reducing the colonic transit time in patients with non-neurological Constipation after a 5 week conditioning period
Number of bowel movements per week; Stool consistency, as measured by the Bristol Stool Form Scale; Quality of life as measured by the Quality of Life Questionnaire (PAC-QOL); Constipation symptoms as measured by PAC-SYM; Laxative use by subjects with functional Constipation
Time to first postoperative bowel movement; Other postoperative medication use; Evaluation of symptoms and quality of life related to Constipation; Symptoms of Over-Effectiveness; Evaluation of symptoms and quality of life related to Constipation 6-weeks postoperatively
Stool frequency (Number of complete bowel movements per day); Stool consistency (Bristol Stool Scale); Severity of symptoms (Constipation Scoring System; CSS); Quality of Life (Patient Assessment of Constipation Quality of Life; PAC-QoL)
Change in complete spontaneous bowel movements (CSBM)/week from baseline to 24 weeks; Increase of at least one CSBM per week from baseline for 9 or more weeks during the 24-week treatment period; Stool frequency/Week (CSBMs and spontaneous bowel movements (SBMs); Stool consistency/week using the 7- point Bristol Stool Form Scale, during the 24 weeks of the study period; Severity of straining using a 5-point ordinal scale (1 indicates not at all; 5 an extreme amount).; Abdominal discomfort, using a 5-point ordinal scale (1 indicates not at all; 5 an extreme amount); Severity of bloating, using a 5-point ordinal scale (1 indicates not at all; 5 an extreme amount); Constipation severity (using a 5-point ordinal scale, with higher scores indicating greater severity); Constipation relief (based on a 7-point balanced scale, with 1 indicating complete relief, 4 indicating no change, and 7 indicating very severe Constipation); Satisfaction with the trial results, using a 5-point ordinal scale; Health related quality of life (using the validated Patient Assessment of Constipation Quality of Life instrument (PAC-QOL); Treatment side effects
Change of weekly average CSBM from baseline; The proportion of participants having three or more CSBMs on average per week; Change of weekly average CSBMs from baseline; Change of weekly average SBMs from baseline; Change of average weekly stool consistency assessment from baseline; Change of average weekly degree of difficulty in defecation from baseline; PAC-QOL; incidence of adverse events; Usage of medicine for Constipation
Percentage of patients showing a positive response to sacral nerve stimulation at 2 months; Clinical characteristics, manometry data, Wexner score of responders to stimulation during the temporary stimulation test (period before the permanent implantation); Clinical characteristics, manometry data, Wexner score of responders to short-term stimulation; Efficacy of neuromodulation; Manometry data, Wexner, QoL and EVA scores, time of colonic transit of responders to prolonged stimulation; To evaluate the investigator opinion about the neuromodulation response, using the patient diary.
Time in hours to passage of first stool post Caesarean Section.; Frequency of abdominal pain between lactulose and non-lactulose groups.; Frequency of nausea and vomiting between lactulose and non-lactulose groups
These studies may lead to new treatments and are adding insight into Constipation etiology and treatment.
A major focus of Constipation research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.