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Corneal Medical Research Studies

Up-to-date List of Corneal Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Corneal Medical Research Studies

Rank Status Study
1 Unknown  Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media
Conditions: Fuch's Endothelial Dystrophy;   Pseudophakic Bullous Keratopathy
Intervention: Procedure: Corneal transplantation
Outcome Measures: The primary outcome is the endothelial cell density of the Corneal grafts prior to and after the transplantation procedure;   Secondary study outcomes are immune mediated graft rejection, non-immune mediated graft failure, as well as the incidence of Corneal edema, Corneal opacities and Corneal neovascularisation.
2 Unknown  Transplantation of Acellular Corneal Matrix to Treat Corneal Ulcer
Condition: Corneal Ulcer
Intervention: Device: acellular Corneal matrix
Outcome Measures: Rejection evaluation;   Corneal wound healing
3 Recruiting Transepithelial Corneal Cross-linking Using Iontophoresis
Condition: Progressive Keratoconus
Interventions: Device: Transepithelial Corneal cross-linking using iontophoresis;   Device: Standard Corneal cross-linking
Outcome Measures: K-max;   Corneal endothelial cell density;   Simulated keratometry;   Optical aberrations;   Visual acuity;   Contrast Sensitivity;   Pain score;   Central retinal thickness
4 Recruiting High-resolution Imaging of Corneal Lesions With Optical Coherence Tomography (OCT) - A Pilot Study
Conditions: Corneal Abrasions;   Corneal Infiltrates
Interventions: Device: Optical Coherence Tomography (OCT);   Other: Slit lamp biomicroscopy
Outcome Measures: Imaging of Corneal abrasions and infiltrates;   Size and depth of Corneal lesions as assessed with high-resolution OCT;   Slit lamp biomicroscopy with fluorescein staining
5 Not yet recruiting Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions
Conditions: Corneal Neovascularization;   Corneal Graft Failure;   Anterior Segment Inflammation
Intervention: Drug: Gamunex-C
Outcome Measures: Ability to regress neovascularization;   Ability to regress neovascularization and promote graft survival;   Need for immunosuppression;   Effect on Corneal infections;   Visual outcome at week 28;   Visual outcome at week 52;   Mean number of injections through week 28;   Mean number of injections through week 52;   Need for rescue treatment in standard of care group
6 Recruiting Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection
Condition: Corneal Ulcers
Interventions: Drug: Riboflavin 0.1%;   Other: UV-X™ Illumination System
Outcome Measures: Number of patients with healed Corneal ulcers;   Number of adverse events
7 Recruiting A Multi-Center, Randomized, Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery
Conditions: Keratoconus;   Corneal Ectasia
Interventions: Device: KXL System (15 mW/cm2);   Device: KXL System (30 mW/cm2);   Device: KXL System (45 mW/cm2);   Drug: riboflavin ophthalmic solution
Outcome Measures: Mean change in maximum Corneal curvature (Kmax) from baseline;   Comparison of treatment groups within each treatment indication
8 Recruiting Comparative Study of Two Corneal Graft Storage Media: New Animal Compound Free Medium Versus Reference Medium
Condition: Corneal Transplantation
Intervention: Procedure: Corneal graft
Outcome Measure: the primary outcome is the endothelial cell density (ECD) of the Corneal grafts.
9 Recruiting Corneal Epithelium Repair and Therapy Using Autologous Limbal Stem Cell Transplantation
Conditions: Corneal Disease;   Pterygium;   Myopia;   Hyperopia
Interventions: Procedure: LSCs and amniotic membrane (Modified Technique);   Procedure: Amniotic membrane only (Traditional Technique);   Procedure: PRK, LSCs, and amniotic membrane (Modified Technique);   Procedure: PRK only (Traditional Technique);   Drug: Levofloxacin;   Drug: Betamethasone;   Drug: Limbal stem cells (LSCs)
Outcome Measures: Composite measure of visual function in eyes treated for Corneal ocular surface disease.;   Composite measure of visual function in eyes after photo-refractive keratectomy (PRK);   Incidence of transparency of the cornea
10 Recruiting Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival
Conditions: Corneal Neovascularization;   Corneal Graft Failure
Interventions: Drug: Avastin® (bevacizumab);   Drug: 0.9% NaCl & Refresh Liquigel
Outcome Measures: Endothelial Rejection Rate;   Time from Surgery to Any Rejection Episode;   Time from Surgery to Graft Failure;   Incidence of Delayed Epithelial Healing;   Endothelial Cell Density;   Central Corneal Thickness;   Frequency of Primary Graft Failure;   Corneal NV Metrics
11 Unknown  Effect of Topical Brimonidine on Post Cataract Surgery Corneal Edema
Conditions: Corneal Edema;   Visual Acuity
Interventions: Drug: Brimonidine Tartrate 0.2%;   Drug: Timolol maleate 0.5%
Outcome Measures: central Corneal thickness in micrometer;   grading of Corneal edema (1-3)
12 Recruiting Village Integrated Eye Workers Trial
Condition: Corneal Ulcer
Intervention: Other: Corneal ulcer prevention program
Outcome Measures: Incidence of Corneal ulceration in the two study arms as measured by Corneal photography;   Trial-based cost effectiveness analysis to determine the incremental cost per Corneal ulcer prevented
13 Unknown  Corneal Endothelium Morphology and Central Thickness in Type II Diabetes Mellitus and Normal Subjects
Condition: Corneal Dystrophy
Intervention:
Outcome Measures: Corneal endothelium cell number;   Corneal endothelium morphology
14 Unknown  UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia
Conditions: Keratoconus;   Ectasia;   Corneal Ectasia
Interventions: Device: UV-X Light;   Drug: Riboflavin
Outcome Measures: Change in Corneal curvature;   corrected distance acuity;   Corneal endothelial cell count;   pachymetry
15 Not yet recruiting A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival
Conditions: Corneal Neovascularization;   Corneal Graft Failure
Interventions: Drug: Avastin® (bevacizumab);   Drug: 0.9% NaCl & Refresh Liquigel
Outcome Measures: Endothelial Rejection Rate;   Incidence of Ocular Adverse Events;   Incidence of Systemic Adverse Events;   Time from Surgery to Any Rejection Episode;   Time from Surgery to Graft Failure;   Incidence of Delayed Epithelial Healing;   Endothelial Cell Density;   Central Corneal Thickness;   Frequency of Primary Graft Failure;   Change in Corneal Neovascularization Metrics
16 Unknown  Evaluation of Corneal Staining With Various Contact Lens/Solution Combinations
Conditions: Corneal Epithelial Disruption;   Corneal Staining
Intervention: Device: Marketed contact lens care products
Outcome Measures: Area of Corneal Staining;   Type (severity) of Corneal Staining
17 Recruiting Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia
Conditions: Keratoconus;   Corneal Ectasia
Intervention: Drug: Riboflavin
Outcome Measures: Maximum keratometry;   Best Corrected Visual Acuity
18 Not yet recruiting Allogeneic Tissue Engineering (Nanostructured Artificial Human Cornea) in Patients With Corneal Trophic Ulcers in Advanced Stages, Refractory to Conventional (Ophthalmic) Treatment
Condition: Corneal Ulcer
Intervention: Other: Anterior lamellar nanostructured artificial human cornea.
Outcome Measures: Appearance of adverse events and serious adverse events related to treatment.;   Persistence of the ulcer or regeneration / repair of the Corneal stroma.;   Visual acuity.;   Corneal transparency
19 Recruiting Studies in Families With Corneal Dystrophy or Other Inherited Corneal Diseases
Conditions: Corneal Dystrophies, Hereditary;   Corneal Disease
Intervention:
Outcome Measure:
20 Recruiting Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia
Conditions: Keratoconus;   Corneal Ectasia
Intervention: Drug: Riboflavin
Outcome Measures: Maximum Keratometry;   Manifest refraction;   Visual Acuity;   Endothelial cell density

These studies may lead to new treatments and are adding insight into Corneal etiology and treatment.

A major focus of Corneal research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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