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Corneal Leukoma Medical Research Studies

Up-to-date List of Corneal Leukoma Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Corneal Leukoma Medical Research Studies

Rank Status Study
1 Recruiting Observational Study of Corneal Opacities in Adults
Condition: Corneal Opacities (Scar and Stromal Dystrophy)
Outcome Measures: Identification of suitable subjects;   Validate OCT anterior topography
2 Recruiting Corneal Opacities in Children
Condition: Corneal Opacities
Outcome Measure: Number of suitable subjects
3 Recruiting The Use of MMC During PRK and Its Effect on Postoperative Topical Steroid Requirements
Condition: Corneal Opacity
Interventions: Drug: Mitomycin-C;   Drug: Fluorometholone 1% topical ocular steroid
Outcome Measures: Refractive Error;   Corneal haze
4 Recruiting Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy
Condition: Corneal Opacity
Intervention: Drug: OCT-guided laser phototherapeutic keratectomy
Outcome Measures: Improvement in best spectacle-corrected visual acuity (BSCVA) after PTK;   Improvement in uncorrected visual acuity (UCVA), refractive error, and higher order aberrations
5 Recruiting OCT-guided LALAK for KCN
Conditions: Corneal Opacity;   Keratoconus
Interventions: Procedure: LALAK;   Procedure: IEK;   Drug: Retrobulbar Block or General Anesthesia;   Device: optical coherence tomography (OCT);   Drug: Topical Anesthesia;   Device: femtosecond laser
Outcome Measure: Does LALAK achieve the same level of post-operative BSCVA as IEK.
6 Recruiting Correlation of Scheimpflug Densitometry Measurements of Corneal Haze With Disability Glare
Condition: Vision Disability
Outcome Measures: Disability glare;   Visual quality;   Contrast sensitivity;   Visual acuity
7 Recruiting Safety and Effectiveness of Collagen-phosphorylcholine Bioengineered Cornea in Patients Requiring Lamellar Keratoplasty
Conditions: Corneal Ulcer;   Leukoma
Intervention: Device: Collagen-MPC cornea
Outcome Measures: Biocompatability;   Corneal healing;   Visual acuity improvement
8 Recruiting Timing of Glaucoma Drainage Device With Boston KPro Surgery
Conditions: Corneal Diseases;   Corneal Opacity
Interventions: Device: Boston keratoprosthesis type 2;   Device: Glaucoma drainage device
Outcome Measures: Visual field mean deviation;   Disc Damage Likelihood Scale (DDLS) on clinical examination;   Disc Damage Likelihood Scale (DDLS) on stereoscopic photographs of the optic nerve;   Ocular complications;   Visual acuity
9 Recruiting Robotic Surgery of the Ocular Surface
Conditions: Keratitis;   Pterygium;   Corneal Opacity Corneal Thinning;   Corneal Perforation
Interventions: Device: 1. Amniotic membrane transplantation on the cornea with the Da Vinci Si HD© robot (Inlay or overlay technique);   Device: Pterygium removal and autograft of the conjunctiva with the Da Vinci Si HD© robot (Kenyon technique);   Device: Penetrating keratoplasty using Baron trephine and nylon stitches with the Da Vinci Si HD© robot
Outcome Measure: Respect for different phases of the operating procedure of each intervention.
10 Recruiting OCT-guided LALAK in Children
Condition: Corneal Opacity
Interventions: Procedure: OCT guided laser-assisted lamellar anterior keratoplasty (LALAK);   Procedure: Penetrating Keratoplasty (KP)
Outcome Measure: Number of LALAK patients with post operative complications compared to PK patients
11 Unknown  Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media
Conditions: Fuch's Endothelial Dystrophy;   Pseudophakic Bullous Keratopathy
Intervention: Procedure: Corneal transplantation
Outcome Measures: The primary outcome is the endothelial cell density of the corneal grafts prior to and after the transplantation procedure;   Secondary study outcomes are immune mediated graft rejection, non-immune mediated graft failure, as well as the incidence of corneal edema, corneal opacities and corneal neovascularisation.
12 Not yet recruiting Corneal Ulcer Prevention Through Health Education
Condition: Corneal Ulcer
Intervention: Other: Health Education
Outcome Measure: Incidence of Corneal Ulcer
13 Unknown  The Role of Amniotic Membrane Transplantation in Ocular Chemical Burns
Condition: Eye Burns
Intervention: Procedure: amniotic membrane transplantation
Outcome Measures: Visual acuity;   Pain;   Symblepharon formation;   Epithelial defect healing;   Corneal opacity and vascularization
14 Recruiting LALAK for Opacities
Interventions: Procedure: LALAK;   Procedure: IEK;   Drug: Retrobulbar Block or General Anesthesia;   Device: optical coherence tomography (OCT);   Drug: Topical Anesthesia;   Device: femtosecond laser
Outcome Measures: BSCVA (Snellen chart);   intraoperative perforation rate;   postoperative refractive error;   topographic astigmatism;   interface clarity;   endothelial cell count;   complications
15 Recruiting Wavefront-guided PRK vs Wavefront-optimized PRK
Conditions: Myopia;   Astigmatism
Interventions: Procedure: Wavefront-guided PRK;   Procedure: Wavefront-optimized PRK
Outcome Measures: Changes in best corrected visual acuity;   Changes in best corrected 5 and 25% contrast visual acuity;   Refractive predictability;   Corneal haze;   Uncorrected visual acuity;   Quality of vision and quality of life questionnaires;   Wavefront analysis;   Topographic analysis
16 Recruiting The Natural History of Mucolipidosis Type IV
Condition: Mucolipidosis Type IV
Outcome Measures: Neuropsychological testing;   Blood tests;   Urine tests;   MRI of the brain;   Rehabilitation evaluation;   Nutritional status evaluation;   Skin biopsy

These studies may lead to new treatments and are adding insight into Corneal Leukoma etiology and treatment.

A major focus of Corneal Leukoma research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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