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Cortril Medical Research Studies

Up-to-date List of Cortril Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Cortril Medical Research Studies

Rank Status Study
1 Recruiting Contribution of Salivary Cortisol in the Detection of Infra-clinic Cortisol Adenoma (ACIC)
Condition: Obesity
Intervention: Other: Salivary Cortisol
Outcome Measures: Number of patients with positive salivary cortisol dosage among patients with positive serum cortisol dosage;   Number of patients with negative salivary cortisol dosage among patients with negative serum cortisol dosage;   Comparing the results of salivary cortisol dosage and serum cortisol dosage;   Comparing the results of the two salivary samples;   Number of patients with metabolic complications of obesity among patients with ACIC;   Number of patients with severe type 2 diabetes among patients with ACIC
2 Not yet recruiting Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease
Condition: Addison Disease
Interventions: Drug: Solu-Cortef;   Drug: Cortef
Outcome Measures: Serum cortisol -24 hours curve;   Salivary cortisol - 24 hours curve;   24 h urine cortisol and metabolites;   levels of corticotropic hormone;   24 hours curve of tissue cortisol;   gene expression
3 Recruiting Sensitivity of Short and Long Allele Carriers of the 5-HTTLPR to Environmental Threat Post Hydrocortisone Administration
Conditions: Major Depressive Disorder;   Anxiety Disorders
Intervention: Drug: Hydrocortisone
Outcome Measure: Change in testosterone concentration
4 Recruiting Continuous Subcutaneous Hydrocortisone Infusion In Addison`s Disease and Type 1 Diabetes
Conditions: Addison Disease;   Type 1 Diabetes
Interventions: Other: Cortef;   Other: Solu-cortef
Outcome Measures: nocturnal hypoglycemic events;   o Nocturnal glycemic variability;   hormone and metabolic profile;   o Subjective health status
5 Not yet recruiting Association Between Low Cortisol Levels and Whiplash Syndrome
Condition: Injuries, Whiplash
Interventions: Drug: Hydrocortisone;   Drug: normal saline 0.9%
Outcome Measure: Prevention of whiplash syndrome according to validated scales of pain and neck motion disability.
6 Recruiting Hydrocortisone Ophthalmic Ointment 0.5% for Treatment of Allergic Conjunctivitis
Condition: Allergic Conjunctivitis
Interventions: Drug: hydrocortisone ophthalmic ointment 0.5%;   Drug: placebo
Outcome Measures: Efficacy of Hydrocortisone Ophthalmic Ointment 0.5% vs. Placebo for the reduction of signs and symptoms associated with allergic conjunctivitis;   Safety of Hydrocortisone Ophthalmic Ointment 0.5% vs. Placebo for the reduction of signs and symptoms associated with allergic conjunctivitis
7 Unknown  Prevention of Posttraumatic Stress Disorder (PTSD) With Early Hydrocortisone Treatment: Pilot
Condition: Posttraumatic Stress Disorder
Interventions: Drug: Hydrocortisone;   Drug: placebo
Outcome Measure: Clinician-Administered PTSD Scale (CAPS)
8 Recruiting Continuous Subcutaneous Hydrocortisone Infusion in Congenital Adrenal Hyperplasia
Condition: Adrenal Hyperplasia, Congenital
Interventions: Drug: Hydrocortisone;   Drug: Cortisone acetate
Outcome Measures: Androgen levels;   Steroid metabolism;   bone metabolism;   fasting glucose;   body mass index;   Dual-energy X-ray absorptiometry (DXA);   Subjective health status;   waist circumference;   hip circumference;   blood pressure;   fasting insulin;   glycated haemoglobin (Hb1AC);   lipid levels;   c-reactive protein
9 Recruiting Hydrocortisone for BPD
Conditions: Infant, Newborn;   Infant, Small for Gestational Age;   Infant, Very Low Birth Weight;   Infant, Premature;   Bronchopulmonary Dysplasia
Interventions: Drug: Hydrocortisone;   Drug: Placebo
Outcome Measures: Efficacy;   Safety;   Morbidity and Growth;   Successful Extubation;   Use of open-label dexamethasone;   Respiratory status at 40 weeks
10 Unknown  Effect of Longer-term Adrenal Suppression Using Low Dose Hydrocortisone on Androgen Overproduction
Conditions: Hyperandrogenemia;   Obesity;   Polycystic Ovary Syndrome
Interventions: Drug: Hydrocortisone;   Drug: dexamethasone;   Drug: Cosyntropin;   Drug: r-hCG (Ovidrel)
Outcome Measures: Changes in free testosterone or 17 OH progesterone levels after ACTH and r-hCG administration respectively, before and after hydrocortisone administration for 12 weeks;   Changes in adrenal and ovarian steroid precursors after ACTH and r-hCG; body composition via air displacement plethysmography, BMI, and glucose tolerance testing results; baseline and after 12 weeks of hydrocortisone administration;   Morning cortisol
11 Unknown  Cortisol Regulation in Polycystic Ovary Syndrome (PCOS)
Condition: Polycystic Ovary Syndrome
Interventions: Drug: pioglitazone;   Drug: metformin;   Drug: placebo
Outcome Measures: The comparison of body surface area adjusted cortisol production rate (CPR/BSA) before and after insulin sensitizing therapy in women with PCOS.;   Comparisons of 24-hour values for adrenocorticotropic hormone , free-cortisol, and cortisol binding globulin.
12 Recruiting Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children
Conditions: Congenital Hydronephrosis;   Congenital Choledochal Cyst;   Fracture
Interventions: Drug: etomidate;   Drug: midazolam;   Drug: propofol
Outcome Measures: Change from baseline in salivary cortisol at the operative day;   Change from baseline in salivary cortisol at the first day after surgery;   Numbers of Acquired Infection Events;   Numbers of using inotropic drugs;   Days of stay in intensive care unit (ICU) after surgery
13 Recruiting Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
Conditions: Septic Shock;   Severe Sepsis;   Acute Lung Injury;   Acute Respiratory Distress Syndrome
Interventions: Drug: Placebo;   Drug: Hydrocortisone
Outcome Measures: All cause mortality;   Ventilator free day;   Vasopressor free day;   Rate of renal replacement therapy;   Organ support free days
14 Not yet recruiting Hydrocortisone for Term Hypotension
Conditions: Infant, Newborn;   Infant, Cardiovascular Insufficiency
Interventions: Drug: Hydrocortisone;   Drug: Placebo
Outcome Measures: Death or neurodevelopmental impairment;   Duration of mechanical ventilation;   Days to full feeds;   Need for gastrostomy tube;   Duration of oxygen requirement;   Need for home oxygen;   Hospital length of stay;   Renal insufficiency;   Necrotizing enterocolitis;   Need for ECMO Therapy;   Death;   Neurodevelopmental Impairment;   Severity of illness;   Inotrope exposure;   Fluid bolus exposure
15 Recruiting Effect of Hydrocortison on Post-ischemic Flow-mediated Dilation and on Thenar Oxygen Saturation in Human Septic Shock.
Conditions: Septic Shock;   Adult
Interventions: Drug: hydrocortison hemisuccinate;   Drug: placebo followed by hydrocortisone hemisuccinate
Outcome Measure: Vasoreactivity
16 Recruiting Pegvisomant With Glucagon Test to Assess for Adult Growth Hormone Deficiency
Condition: Adults Growth Hormone Deficiency.
Interventions: Drug: Pegvisomant;   Drug: Regular insulin
Outcome Measures: Peak growth hormone and cortisol levels induced by the pegvisomant-glucagon test compared to those by the insulin tolerance test in assessing the growth hormone and cortisol reserve in adults suspected of adult growth hormone and cortisol deficiencies.;   Correlation of peak GH and cortisol levels to BMI and fasting glucose, and effects of pegvisomant on IGF-I bioactivity.
17 Recruiting Comparison of Cortisol Pump With Standard Treatment for Congenital Adrenal Hyperplasia
Conditions: Adrenal Insufficiency;   Excess Androgen;   Congenital Adrenal Hyperplasia (CAH)
Interventions: Drug: Hydrocortisone (Solucortef);   Device: Insulin pump (Medtronic)
Outcome Measures: Percent of patients with 17-OH Progesterone levels equal or below 1,200 ng/dL at 8 a.m.;   Percent of patients with hypertensive BP measurements;   Body composition measured by DEXA;   Weight and BMI;   Insulin resistance measured by HOMA-IR;   Change in percent of patients with androstenedione & amp; testosterone within the normal range at 8 a.m.;   Fatigue and quality of life.
18 Recruiting ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock
Condition: Septic Shock
Interventions: Drug: Hydrocortisone;   Drug: Sterile air filled vial
Outcome Measures: All cause mortality at 90 days after randomisation;   All-cause mortality at 28 days and 6 months after randomisation;   Time to resolution of shock;   Recurrence of shock;   Duration of ICU stay;   Duration of hospital stay;   Frequency and duration of mechanical ventilation;   Duration of renal replacement therapy;   Development of bacteraemia;   Bleeding requiring blood transfusions received in the ICU;   Quality of Life assessment at 6 months.
19 Recruiting Efficacy of Single Dose IV Hydrocortisone in Post Traumatic Stress Disorder (PTSD) Prevention
Condition: Post Traumatic Stress Disorder
Interventions: Drug: Placebo;   Drug: Hydrocortisone
Outcome Measure: The primary outcome is PTSD diagnosis at the end of the trial .This will be determined using the Clinician Administered PTSD Scale (CAPS), a scale with established reliability and good psychometric properties.
20 Recruiting Effects of Systemically Administered Hydrocortisone on the Immune System in Healthy Volunteers
Conditions: Immunosuppression;   Healthy;   Healthy Subjects
Intervention:
Outcome Measure: Effects of hydrocortisone on the human immune

These studies may lead to new treatments and are adding insight into Cortril etiology and treatment.

A major focus of Cortril research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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