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Cough Medical Research Studies

Up-to-date List of Cough Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Cough Medical Research Studies

Rank Status Study
1 Recruiting The Effect of Pirfenidone on Cough in Patients With Idiopathic Pulmonary Fibrosis
Condition: Idiopathic Pulmonary Fibrosis
Intervention: Other: Cough monitor
Outcome Measures: Change in Cough frequency measured by Cough recorder at week 12 compared to baseline;   Impact of Cough on quality of life;   Change in Cough frequency measured by Cough recorder at 4 weeks compared to baseline
2 Not yet recruiting Comparison of Efficacy and Tolerability of Two Cough Syrups in Cough Due to Cold in Children.
Conditions: Cough;   Upper Respiratory Tract Infection
Interventions: Device: protective Cough syrup;   Drug: carbocisteine Cough syrup
Outcome Measures: reduction in night Cough severity;   reduction in day Cough severity
3 Recruiting Cough Determinants in Mechanically Ventilated Patients
Condition: Mechanical Ventilation
Intervention: Other: Functional respiratory evaluation
Outcome Measures: Interest of systematically Cough evaluation before extubation;   Correlation between success of extubation and respiratory parameters
4 Not yet recruiting An Investigation Into the Mechanism of Inhalation Cough Challenge
Condition: Cough
Interventions: Other: Nebulised citric acid in serial dilutions;   Other: Nebulised ATP solution in serial dilutions;   Other: Nebulised TRPA1 agonist solution in serial dilutions
Outcome Measure: Difference in mean C5 (concentration of inhaled substance required to elicit 5 Coughs) between the chronic Cough arm and the normal volunteer arm.
5 Unknown  Evaluation of Efficacy and Safety in Control Cough and the Relief of Nasal Symptoms in Children 2-12 Years Old,Suffering From Cough and Acute Rhinitis
Conditions: Inflammation;   Cough;   Rhinitis
Interventions: Drug: diphenhydramine + dropropizine + pseudoephedrine;   Drug: Dropropizine and fixed dose combination of pseudoephedrine hydrochloride + brompheniramine maleate (Dimetapp® elixir).
Outcome Measures: Improvement of nasal congestion and Cough;   Improvement of non-obstructive nasal symptoms;   Reduction of the frequency of nighttime awakenings of parent/guardian/roommate of the child;   Reduction of vomiting frequency episodes triggered by Coughing;   Improvement of acute rhinitis signs;   Use of rescue medication;   Overall impression of improvement by the investigator;   Safety descriptive about occurence of adverse events, evaluation of results of general physical examination.
6 Not yet recruiting The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.
Condition: Chronic Cough
Intervention: Other: capsaicin challenge
Outcome Measure: Cough reflex hypersensitivity
7 Recruiting Cough Assist in Bronchiolitis
Conditions: Bronchiolitis;   Respiratory Syncytial Virus
Intervention: Device: Cough Assist
Outcome Measures: Oxygen requirement;   Atelectasis;   Bronchoscopy;   Hypercapnia;   Hospitalization length
8 Recruiting GSK2339345 Hypertussive Challenge Study
Condition: Cough
Interventions: Drug: GSK2339345;   Drug: Placebo
Outcome Measures: Total Cough counts in Part A.;   Number of Coughs following each dose of capsaicin, following a single dose of GSK2339345 or placebo;   Number of Coughs following each dose of citric acid, following a single dose of GSK2339345 or placebo;   Cough counts following GSK2339345 or placebo at Visits 1, 2 and 3 over shorter epochs (e.g. 1 hour or 15 minute intervals);   Urge to Cough visual analogue scale (VAS) 1 hour post-last dose at Visits 1, 2 and 3;   Cough severity VAS 1 hour post-last dose at Visits 1, 2 and 3;   To assess the safety profile of GSK2339345 versus placebo;   The systemic pharmacokinetics (PK) profile of GSK2339345.
9 Recruiting Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests
Conditions: Asthma;   Cough Variant Asthma
Interventions: Drug: high-dose methacholine challenge test;   Other: mannitol challenge test
Outcome Measures: PD15 (15% fall in forced expiratory volume in one second (FEV1) from baseline during challenge test visits);   %ΔFEV1 (percentage change in forced expiratory volume in one second);   Plateau response;   Dose-response slope;   Expiratory Flow Limitation (EFL)
10 Unknown  Evaluation of the Efficacy and Tolerability of ABO/MEG-B-09 in Children With Acute Cough
Condition: Cough
Interventions: Device: AboMeg-B-09;   Other: Placebo
Outcome Measures: Cough score variation;   Cough reflex sensitivity;   Objective breath sounds;   The ventilation of the various pulmonary zones;   Quality of life
11 Unknown  Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From Non-productive Cough and Acute Rhinitis
Conditions: Nasal Congestion;   Cough
Interventions: Drug: Group 1;   Drug: Group 2
Outcome Measures: Primary efficacy criteria;   Secondary efficacy criteria
12 Unknown  Bromelin, a Compound Prepared With Ananas Comocus Extract and Honey, for Acute Cough
Condition: Cough, Acute
Interventions: Drug: Bromelin;   Drug: Placebo
Outcome Measures: Change in score in a Cough evaluation questionnaire;   Change in Occurrence of gastric symptoms
13 Unknown  Sputum and Plasma Levels of Nociceptin and Substance P in Patients With Asthma, COPD and Chronic Cough
Conditions: Asthma;   COPD;   Cough
Intervention:
Outcome Measure:
14 Recruiting Comparison Between Oxomemazine, Guaifenesin and Potassium Iodate Versus Guaifenesin Monotherapy in Acute Cough Treatment
Condition: Cough
Interventions: Drug: Syrup of oxomemazine, guaifenesin and potassium iodate;   Drug: Syrup of guaifenesin
Outcome Measures: Reduction/improvement of Cough symptoms;   Tolerance
15 Unknown  Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin
Condition: Cough
Interventions: Drug: Guaiacol, eucalyptol, menthol and camphor suppository;   Drug: guaiacol suppository;   Drug: Guaifenesin syrup
Outcome Measures: Improvement of Cough of infectious origin.;   Analysis of parameters for the improvement of infectious Cough.
16 Recruiting Peak Cough Flow and Cough Clearance
Condition: Duchenne Muscular Dystrophy
Intervention:
Outcome Measure: Spontaneous Cough clearance
17 Unknown  Efficacy and Safety Study of Procaterol Hydrochloride to Treat Patients With Cough Variant Asthma (CVA)
Condition: Cough Variant Asthma
Interventions: Drug: Procaterol hydrochloride;   Drug: Meptin placebo
Outcome Measures: Patient Cough symptom score;   Therapy duration;   Rates of adverse events;   LCQ Life Quality Score
18 Recruiting The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma
Conditions: Eosinophilic Bronchitis;   Cough Variant Asthma
Intervention: Drug: Bambuterol Hydrochloride tablets
Outcome Measures: Day-time and night-time Cough symptom total-score changes from baseline to day 3.;   Cough sensitivity from baseline to day 3
19 Recruiting Bronchodilating and Bronchoprotective Effects of Deep Inspirations
Conditions: Asthma;   Cough
Intervention: Other: Methacholine Challenge Testing
Outcome Measures: Mid expiratory flows;   percent fall in FEV1;   respiratory system reactance (X5);   peripheral resistance (R5-R20);   Central airway resistance;   Forced vital capacity (FVC);   FEV1/FVC
20 Recruiting Cough and Swallow Rehab Following Stroke
Condition: Ischemic Stroke
Interventions: Behavioral: Expiratory muscle strength training;   Behavioral: Placebo expiratory training;   Drug: Measures perfomed on all subjects;   Behavioral: Pulmonary function test;   Radiation: Fluoroscopic swallow study
Outcome Measures: Maximum Expiratory Pressure;   Cough expiratory airflow

These studies may lead to new treatments and are adding insight into Cough etiology and treatment.

A major focus of Cough research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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