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Coversyl plus Medical Research Studies

Up-to-date List of Coversyl plus Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Coversyl plus Medical Research Studies

Rank Status Study
1 Recruiting Intracardiac CrYoablation for AtrioVentricular Nodal Reentrant Tachycardia
Conditions: AtrioVentricular Nodal Reentrant Tachycardia;   Supraventricular Tachycardia;   Heart Disease
Intervention: Device: Freezor Xtra Cryoablation Catheter
Outcome Measures: Number of Participants with Successful Procedures and No AtrioVentricular Nodal Reentrant Tachycardia Recurrence;   Number of Participants with Adverse Events as a Measure of Safety;   Number of Participants who had Acutely Successful Procedures and No Atrioventricular Nodal Reentrant Tachycardia Recurrence.
2 Recruiting Trial Comparing Ablation With Medical Therapy in Patients With Ventricular Tachycardia
Conditions: Ventricular Tachycardia;   Coronary Artery Disease
Interventions: Procedure: Catheter Ablation;   Drug: Medical therapy (sotalol or amiodarone)
Outcome Measures: Recurrence of Ventricular Tachycardia;   Time to First Shock/ATP for VT or to First Presentation of Sustained VT;   Total mortality;   Sudden cardiac death;   Syncope;   Number of hospitalizations;   QOL measures
3 Unknown  Anti-arrhythmic Medication v. MRI-Merge Ablation in the Treatment of Ventricular Tachycardia
Condition: Ventricular Tachycardia
Interventions: Procedure: MRI guided VT ablation;   Drug: Increased dose of amiodarone
Outcome Measures: Freedom from ventricular tachycardia documented by implantable defibrillator cardioverter 6 months post ablation.;   inducible arrhythmia at the end of the procedure,;   Procedure time;   Comparison of endocardial voltage mapping to scar on delayed enhancement MRI images;   Complications of the procedure
4 Not yet recruiting Intramural Needle Ablation for Ablation of Recurrent Ventricular Tachycardia
Condition: Ventricular Tachycardia
Intervention: Device: Intramural Needle Ablation Catheter
Outcome Measures: Control of Ventricular Tachycardia (VT);   Absence of all serious adverse events;   Acute Procedural Success
5 Recruiting Feasibility of Contact Force Catheter Mapping and Ablation in Epicardial and Endocardial Ventricular Tachycardias
Conditions: Ventricular Tachycardia;   Sudden Death;   Syncope;   Chest Pain
Intervention: Procedure: Catheter ablation
Outcome Measures: Evaluate the feasibility of mapping and ablating ventricular tachycardias in endocardial and epicardial using a contact force catheter;   Evaluate the impedance and voltage threshold for scar in chronic chagasic cardiomyopathy
6 Recruiting Ventricular Tachyarrhythmia Detection by Implantable Loop Recording in Patients With Heart Failure and Preserved Ejection Fraction
Condition: Heart Failure With Preserved Ejection Fraction (HFpEF)
Intervention: Device: ILR implantation
Outcome Measures: The incidence of sustained ventricular tachyarrhythmias.;   The incidence of atrial fibrillation (AF) in patients without baseline or history of AF;   The rate of progression of AF in patients without baseline or history of AF;   The incidence of HF hospitalizations, all cause mortality, cardiovascular mortality, and sudden cardiac death;   The incidence of non-sustained ventricular tachyarrhythmias;   Biomarkers (including ECG, Holter, echocardiography, CMR and blood biomarkers) for incident AF, and progression of AF in patients without baseline or history of AF;   Biomarkers (including ECG, Holter, echocardiography, CMR and blood biomarkers) of sustained ventricular tachyarrhythmias;   Biomarkers (including ECG, Holter, echocardiography, CMR and blood biomarkers) of non-sustained ventricular tachyarrhythmias;   Biomarkers (including echocardiography, ECG and other arrhythmogenic markers and blood biomarkers) for development of HF hospitalizations, sudden death, arrhythmic death, and all-cause mortality
7 Recruiting Ventricular Tachycardia (VT) Ablation Versus Enhanced Drug Therapy
Condition: Recurrent Ventricular Tachycardia
Interventions: Procedure: Catheter Ablation;   Drug: Aggressive Antiarrhythmic Therapy (Amiodarone)
Outcome Measures: Appropriate ICD shocks,VT storm and death;   All cause mortality
8 Unknown  Dexmedetomidine Versus Adenosine: Electrophysiologic Effects and Therapeutic Use for Terminating Supraventricular Tachycardia
Condition: Supraventricular Tachycardia
Interventions: Drug: Dexmedetomidine;   Drug: Adenosine
Outcome Measures: Termination of SVT;   Incidence and duration of sinus pause or asystole after termination of SVT;   Incidence of Tachyarrhythmias;   Hypotension and hypertension
9 Recruiting Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia Syndrome
Condition: Postural Orthostatic Tachycardia Syndrome
Interventions: Other: History;   Other: Physical;   Other: blood draw;   Behavioral: Questionnaires
Outcome Measures: Ab titer in POTS patients compared to control subjects;   comparison of the number of POTS patients with viral based Ab versus non-viral based Ab;   comparison of the number of POTS patients with and without Ehlers Danlos syndrome III;   comparison of the number of POTS patients with a history of autoimmune disorders versus no history of auto-immune disorders;   comparison of the number of POTS patients with fatigue versus no history of fatigue based on severity of impact on normal daily activities.;   comparison of pain in POTS patients versus non-POTS patients
10 Recruiting Ablation of Inappropriate Sinus Tachycardia
Condition: Inappropriate Sinus Tachycardia
Intervention: Procedure: electrophysiology study and radiofrequency ablation
Outcome Measures: Improvement in:symptoms(palpitations);quality of life;resting heart rate;mean 24 hour heart rate;heart rate variability;;   duration of symptom limited Bruce protocol exercise treadmill test;duration of exercise test required to increase rate by 20%.
11 Unknown  Testing Objective Methods for Template Matching Ventricular Tachycardia and Pacemapping
Condition: Ventricular Tachycardia
Intervention:
Outcome Measure: Correlating the arithmetic markers (CORR and MAD) to the distance between the pacing site and origin of the ventricular tachycardia or the index pacing site.
12 Recruiting Dietary Salt in Postural Tachycardia Syndrome
Condition: Postural Orthostatic Tachycardia Syndrome
Interventions: Radiation: Blood Volume;   Radiation: Total Blood Volume;   Procedure: Exercise Capacity Test - Bicycle;   Procedure: Posture Study
Outcome Measures: blood volume;   Magnitude of suppression of aldosterone (from low sodium to high sodium diets) and a reduction in orthostatic tachycardia and orthostatic symptoms in POTS patients with the high-sodium diet.
13 Recruiting AV Nodal Reentrant Tachycardia Study
Condition: Tachycardia, Atrioventricular Nodal Reentry
Intervention: Procedure: Cardiac Invasive Electrophysiological Study
Outcome Measure: raise the frequency of success to more than 98%
14 Not yet recruiting Fibrillatory Factor in Ventricular Tachycardia
Condition: Ventricular Tachycardia
Intervention: Procedure: Fibrillatory Factor calculation (FF)
Outcome Measures: Fibrillatory Factor;   Real-time fibrillatory factor
15 Unknown  Hemodynamic Differentiation of Tachycardia Episodes Using Tissue Perfusion
Condition: Arrhythmias, Cardiac
Interventions: Procedure: High rate atrial and vetricular stimulation;   Procedure: Ventricular Tachycardia induction
Outcome Measures: Change in hemodynamic state during all tachycardia;   Change in hemodynamic state during SVT
16 Recruiting Yoga and Rate and Duration of Inappropriate Sinus Tachycardia (IST) Episodes
Condition: Inappropriate Sinus Tachycardia
Intervention: Other: Yoga
Outcome Measures: Determine if Yoga affects the rate and duration of IST episodes;   Effect yoga has on resting heart rate or occurrence of IST episodes in patients that have undergone treatment with medications and/or ablation procedures;   Change in Quality of Life
17 Recruiting Ultra-high Density Mapping With Multielectrode Catheter vs Conventional Point by Point Mapping for Ventricular Tachycardia Substrate Ablation
Condition: Ventricular Tachycardia
Interventions: Device: Ablation guided by conventional mapping.;   Device: Ablation guided by ultra-high density mapping with multielectrode catheter.
Outcome Measures: Mapping and ablation times;   Scar area correlation with MRI.;   Radiofrequency delivery time.;   Reduction of residual electrograms with delayed component.;   Ventricular tachycardia inducibility after ablation.
18 Recruiting Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)
Conditions: Postural Tachycardia Syndrome;   Postural Orthostatic Tachycardia Syndrome
Interventions: Device: Inspiratory Threshold Device (Res-Q-Gard ITD);   Device: Sham Inspiratory Threshold Device
Outcome Measures: Magnitude of orthostatic heart rate increase on upright posture;   Symptoms rating with upright posture;   Hemodynamic changes on upright posture
19 Recruiting Aldosterone & Sodium Regulation in Postural Tachycardia Syndrome - Screening
Condition: Postural Tachycardia Syndrome
Interventions: Other: Autonomic Function Testing;   Other: Posture Study;   Procedure: Measurement of Total Blood Volume;   Other: Exercise Capacity Test
Outcome Measure: blood volume deviation (%) from individual predicted volumes
20 Unknown  Iv Amiodarone Versus Iv Procainamide to Treat Haemodynamically Well Tolerated Ventricular Tachycardia
Conditions: Ventricular Tachycardia;   Wide QRS Tachycardia
Intervention: Drug: iv Amiodarone and iv Procainamide
Outcome Measures: To compare clinically significant cardiac adverse events occurring within 40 minutes from treatment initiation;   To compare efficacy of both therapies in relation to episode termination;   To compare the rate of total adverse events, cardiac and non cardiac, occurring during an observation period of 24 hours after treatment was applied

These studies may lead to new treatments and are adding insight into Coversyl plus etiology and treatment.

A major focus of Coversyl plus research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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