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Cyclogest Medical Research Studies

Up-to-date List of Cyclogest Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Cyclogest Medical Research Studies

Rank Status Study
1 Recruiting Optimal Length of Progesterone Supplementation Before the Transfer of Cryopreserved (Frozen)-Thawed Day 3 Embryos in an Artificial Cycle With Exogenous Estrogen and Progesterone
Condition: Progesterone Supplementation
Intervention: Drug: Progesterone
Outcome Measures: clinical pregnancy rate;   live birth rate
2 Recruiting Uterine Electrical Activity Before and After Progesterone Treatment for Preterm Labor
Condition: Preterm Labor
Interventions: Drug: Experimental: Vaginal progesterone;   Drug: Experimental: Topical progesterone;   Drug: Experimental: Intramuscular progesterone
Outcome Measures: Inhibition of uterine electromyographic (EMG) activity by various formulations of progesterone.;   Effects of progesterone on uterine EMG activity and preterm birth
3 Unknown  Efficacy and Tolerability Study of Progesterone Vaginal Tablets (Endometrin®) in Menopausal Women Treated by Estrogen
Conditions: Endometrial Hyperplasia;   Endometrial Cancer
Interventions: Drug: progesterone;   Drug: activella
Outcome Measures: Comparing the proportion of women with endometrial thickness not exceeding 8mm and change not exceeding 3mm between the two groups.;   Comparison of the proportion of bleeding pattern between the two groups.;   To demonstrate that vaginal progesterone tablets decrease systemic progesterone adverse reactions using a questionnaire.
4 Unknown  Luteal Phase Support With Progesterone Versus Estrogen and Progesterone on Pregnancy Rates
Conditions: Unexplained Infertility;   Mild Male Factor
Interventions: Drug: Luteal support with progesterone only;   Drug: Luteal support with estrogen + progesterone;   Procedure: Insemination without luteal support
Outcome Measure: Clinical Pregnancy
5 Unknown  A Prospective Randomized Multicentre Study to Compare Crinone 8% Once Daily Versus Other Vaginal Progesterone.
Condition: IVF - Luteal Phase Support After Embryo Transfer
Interventions: Drug: progesterone;   Drug: Progesterone
Outcome Measures: Equivalence in ongoing pregnancy per embryo transfer between the two groups;   Convenience for the patient
6 Recruiting Progesterone and Brain Imaging Study
Conditions: Nicotine Dependence;   Nicotine Withdrawal
Intervention: Drug: Progesterone
Outcome Measures: Change from Baseline in Occipital Cortex GABA Pre and Post Placebo Administration;   Change from Baseline in Occipital Cortex GABA Pre and Post Progesterone Administration;   Withdrawal Symptoms
7 Recruiting Influence of Progesterone Administration on Drug-Induced QT Interval Lengthening
Condition: Focus of the Study is to Determine if Oral Progesterone Administration Attenuates Drug-induced QT Interval Lengthening in Women
Interventions: Drug: Progesterone;   Drug: Placebo
Outcome Measures: Maximum individual-corrected QT interval (QTcI);   Area under the QTcI - time curve (AUEC);   QTcI EC50;   Incidence of progesterone-associated adverse effects
8 Recruiting Vaginal Progesterone for Prevention of Preterm Birth After an Episode of Preterm Labor
Condition: Preterm Birth
Interventions: Drug: Progesterone;   Drug: placebo vaginal capsules
Outcome Measures: Preterm delivery (before completed 37th week of gestation);   Changes in uterine electromyographic (EMG) activity;   Cervical length changes
9 Recruiting Oral Micronized Progesterone for Perimenopausal Vasomotor Symptoms
Conditions: Hot Flushes;   Night Sweats
Interventions: Drug: Oral micronized progesterone;   Drug: placebo
Outcome Measures: Vasomotor Symptoms (VMS)/ VMS Score;   Frequency of VMS;   Severity of VMS;   Sleep problems;   Mood;   Health-related Quality of Life
10 Not yet recruiting Utrogestan Versus Nifedipine as Tocolysis for Preterm Labor: a Randomised Controlled Trial
Condition: Preterm Labor
Interventions: Drug: utrogestan;   Drug: Nifedipine
Outcome Measures: latency period interval between time of tocolysis and delivery;   Pregnancy outcomes;   Neonatal outcome;   Maternal side effect
11 Recruiting Progesterone and Vitamin D3 in Women With LOBC and LABC - A Feasibility Study
Conditions: Breast Cancer;   Locally Advanced Malignant Neoplasm
Interventions: Drug: Cholecalciferol;   Drug: Inj. Progesterone;   Drug: Doxyrubicin or Epirubicin
Outcome Measures: Disease-free survival;   Improvements in overall survival, Tumor response
12 Not yet recruiting Progesterone for Postpartum Smokers
Condition: Tobacco Use Disorder
Interventions: Drug: Progesterone;   Drug: Placebo
Outcome Measures: Feasibility of progesterone as a relapse prevention intervention for postpartum women with pre-conception smoking;   Relapse to smoking after delivery
13 Recruiting Randomized Controlled Trial of Vaginal Progesterone in Women With Threatened Preterm Labor
Condition: Obstetric Labor, Premature
Interventions: Drug: Vaginal progesterone;   Drug: Placebo
Outcome Measures: Gestational age at birth;   Proportion of women who have preterm birth <35 weeks;   Proportion of women who have a preterm birth at <37 weeks;   Maternal hospital length of stay (days);   Proportion of women who have hospital admission for premature labor;   Maternal compliance with treatment;   Neonatal hospital length of stay (days);   Neonatal morbidity;   Number of days of assisted ventilation (neonate);   Number of days of supplemental oxygen (for neonate);   Birth weight (grams);   Neonatal survival to discharge home (yes/no);   Adverse events (maternal or neonate)
14 Recruiting Progesterone and Second Trimester Bleeding
Conditions: Antepartum Bleeding;   Preterm Birth
Interventions: Drug: micronized progesterone 200 mg (Utrogestan);   Drug: placebo
Outcome Measures: Incidence of spontaneous preterm birth - before 37 weeks.;   Maternal and fetal outcomes
15 Recruiting Optimal Length of Progesterone Supplementation Before the Transfer of Cryopreserved(Frozen)-Thawed Embryos in an Artificial Cycle With Exogenous Estrogen and Progesterone.
Conditions: Cryopreservation;   Embryo Implantation;   Progesteron
Intervention: Drug: Progesterone
Outcome Measures: clinical pregnancy rate;   live birth rate
16 Not yet recruiting Uterine Contractions and Mode of Progesterone in Frozen Embryo Transfer (FET) Cycles: Randomized Clinical Trial
Conditions: In Vitro Fertilization;   Embryo Transfer;   Drug Effects
Interventions: Drug: Progesterone in oil;   Drug: vaginal progesterone suppositories
Outcome Measures: number of uterine endometrial contractions per minute;   Implantation Rate
17 Recruiting Time Course of Waking Versus Sleep-associated Luteinizing Hormone (LH) Pulse Frequency Suppression in Response to Progesterone in Late Pubertal Girls With and Without Hyperandrogenemia
Condition: Hyperandrogenemia
Interventions: Drug: Micronized progesterone suspension;   Drug: Placebo
Outcome Measures: Luteinizing hormone pulse frequency;   Progesterone;   Testosterone;   Estradiol;   Luteinizing hormone pulse amplitude;   Sleep parameters (e.g., sleep stages)
18 Recruiting Preconceptional Progesterone Treatment in Women With Unexplained Recurrent Miscarriage, A Randomized Double-blind Controlled Trial
Condition: Abortion, Habitual
Intervention: Drug: Progesterone
Outcome Measures: Live births beyond 32 weeks;   Gestation at delivery and fetal weight AND Congenital abnormalities with specific examination for genital anomalies
19 Recruiting Assessment of Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition
Conditions: Hyperandrogenemia;   Polycystic Ovary Syndrome
Interventions: Drug: Progesterone;   Drug: Estrace (estrogen)
Outcome Measure: LH Pulse frequency as a function of day 7 progesterone
20 Not yet recruiting Luteal Phase Progesterone in IUI and Gonadotropin Cycles
Condition: Infertility
Intervention: Drug: Progesterone Effervescent Vaginal Tablets
Outcome Measures: Clinical pregnancy rate;   Biochemical Pregnancy;   Non-viable Pregnancy;   Multiple Pregnancy

These studies may lead to new treatments and are adding insight into Cyclogest etiology and treatment.

A major focus of Cyclogest research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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