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Cystitis Medical Research Studies

Up-to-date List of Cystitis Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Cystitis Medical Research Studies

Rank Status Study
1 Recruiting The Efficacy of Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome
Condition: Interstitial Cystitis
Outcome Measures: To compare of expression of the biomarker such as APF, HB-EGF, MCP-1 among the Hunner's ulcer interstitial Cystitis and non-ulcer interstitial Cystitis and control groups;   To compare of changes voiding parameters after bladder biopsy between Hunner' ulcer group and non-ulcer group;   TO compare of change of scores of questionnaires such as O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q), Pelvic Pain and Urgency/Frequency Patient Symptom Scale(PUF), Visual Analogue Scale (Pain) between Hunner's ulcer group and non-ulcer group
2 Unknown  Sacral Neuromodulation in Patients With IC
Condition: Interstitial Cystitis
Intervention: Device: Interstim
Outcome Measures: To determine if bilateral sacral neuromodulation will reduce the patient's score on the Interstitial Cystitis Symptom and Problem Questionnaire by at least 25% when compared to unilateral sacral neuromodulation in patients with interstitial Cystitis.;   To determine if bilateral sacral neuromodulation will improve the patient's voiding diary defined as reduction in urinary frequency by 25% from baseline when compared to unilateral sacral neuromodulation in patients with interstitial Cystitis
3 Recruiting Osteopathic Manipulation for Female Interstitial Cystitis Patients With Sacroiliac Joint Dysfunction
Conditions: Interstitial Cystitis;   Sacroiliac Joint Somatic Dysfunction
Intervention: Procedure: Osteopathic Manipulation Therapy
Outcome Measure: Improvement in Scores of Validated questionnaires pertaining to Interstitial Cystitis problems and symptoms
4 Recruiting Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome
Conditions: Painful Bladder Syndrome;   Interstitial Cystitis;   Pelvic Floor; Insufficiency;   Bowel Dysfunction;   Sexual Dysfunction;   Pelvic Floor; Incompetency
Intervention: Other: Changing the Interstim parameter of '' Frequency" in patients with Interstitial Cystitis
Outcome Measures: Improvement in Urinary symptoms and Bladder pain/discomfort;   Improvement in Bowel symptoms and Sexual Function
5 Recruiting Interstitial Cystitis: Elucidation of the Psychophysiologic and Autonomic Characteristics (ICEPAC) Study
Conditions: Interstitial Cystitis/Painful Bladder Syndrome;   Myofascial Pelvic Pain
Intervention: Drug: Bupivacaine
Outcome Measures: Interstitial Cystitis;   Myofascial Pelvic Pain;   Depression Symptoms;   Stress Symptoms
6 Recruiting Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis
Condition: Interstitial Cystitis
Interventions: Drug: Oxytocin;   Other: Saline as a nasal spray
Outcome Measures: Our primary outcome measure will be the global response assessment(GRA)score;   Secondary outcome measures will include verbal reports of anxiety and pain, micturition frequency, and concomitant medication use for pain and/or anxiety.
7 Recruiting Bladder Thermal Distention for Patients With Interstitial Cystitis / Painful Bladder Syndrome
Conditions: Interstitial Cystitis;   Painful Bladder Syndrome
Intervention: Procedure: Bladder Thermal Distention
Outcome Measures: o'leary sant questionnaire;   Bladder diary
8 Recruiting Comparative Study Between Hyperbaric Therapy and Intravesical Dimethyl Sulfoxide Instillation for Interstitial Cystitis
Condition: Interstitial Cystitis
Interventions: Other: Hyperbaric Oxygen Therapy;   Drug: DMSO
Outcome Measures: Subjective improvement will be assessed by several questionnaires: the Oleary Sant symptom index score, bladder diary, 1-10 visual analogue scale for pain, PSQ4 questionnaire;   Objective improvement will be assessed by urodynamic test. The following parameters will be addressed: cystometric capacity, 1st sensation, normal sensation
9 Unknown  Comparison in the Treatment of Acute Cystitis Using Cephalosporin and Norfloxacin (CECI)
Condition: Cystitis
Interventions: Drug: Norfloxacin;   Drug: Cephalosporins
Outcome Measures: Bacteriological Eradication;   Clinical Cure
10 Recruiting The Efficacy of Additional Intravesical Instillation of Hyaluronic Acid/Chondroitin Sulfate to Transurethral Resection of Bladder Ulcer in Patients With Interstitial Cystitis/Bladder Pain Syndrome.
Condition: Interstitial Cystitis
Intervention: Drug: Hyaluronic acid/chondroitin sulfate
Outcome Measures: Change of pain scores on the Visual Analogue Scale;   Duration of symptom improvement;   Changes of frequency and urgency on voiding diary;   Change score of O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q);   Score of Global Response Assessment (GRA), Patient Global Assessment (PGA) score;   Occurrence of adverse event;   Change score of Pelvic Pain and Urgency/Frequency Patient Symptom Scale(PUF);   Change score of EQ-5D Health Questionnaire;   Change score of Brief Pain Inventory-short form (BPI-sf)
11 Recruiting Cyclosporine in Interstitial Cystitis: Efficacy, Safety and Mechanism of Action
Condition: Interstitial Cystitis
Intervention: Drug: Cyclosporine
Outcome Measure: To measure the effects of cyclosporine treatment on current perception and pain threshold using a Neurometer before, during and after treatment
12 Unknown  Genetic Studies in Interstitial Cystitis
Conditions: Interstitial Cystitis;   Painful Bladder Syndrome;   Chronic Pelvic Pain Syndrome
Outcome Measure:
13 Recruiting Ibuprofen Versus Mecillinam for Uncomplicated Cystitis
Condition: Acute Cystitis (Excl in Pregnancy)
Interventions: Drug: Ibuprofen;   Drug: Mecillinam
Outcome Measures: Number of patients who are symptom free by day four;   The patients' symptom load with regard to specific symptoms.
14 Unknown  Acupuncture for the Treatment of Interstitial Cystitis (IC) Symptoms
Condition: Interstitial Cystitis
Intervention: Procedure: Acupuncture
Outcome Measures: Rate of improvement between arms as indicated by a Patient Overall Rating of Improvement Scale;   Improvement in Interstitial Cystitis Symptom and Problem Indices (validated symptom-specific measures);   Improvement in University of Wisconsin-Interstitial Cystitis Scale (validated symptom-specific measure);   Improvement in frequency, urgency and nocturia as measured on bladder diaries
15 Recruiting Intravesical Botulinum Toxin A Injections in Treatment of Interstitial Cystitis Refractory to Conventional Treatment
Condition: Interstitial Cystitis
Interventions: Drug: Botulinum toxin A;   Drug: Normal saline instillation
Outcome Measures: Net change of Patient Perception of Visual Analogue Scale (VAS);   Net change of Patient Perception of global response assessment (GRA);   Net change of O'Leary-Sant symptom and problem indexes;   Net change of the functional bladder capacity (FBC);   Net change of the number of urinary frequency;   Net change of the number of nocturnal;   Net change of the Quality of Life (QoL);   Net change of the maximal flow rate (Qmax);   Net change of the voided volume;   Net change of the residual urine volume (PVR)
16 Unknown  Efficacy of Botulinum Toxin Type A in Patients With Bladder Pain Syndrome/Intersticial Cystitis and Hunners' Lesions
Condition: Interstitial Cystitis
Interventions: Procedure: intratrigonal injection of botulinum toxin;   Procedure: cystoscopy
Outcome Measures: Change from baseline in pain intensity;   Change from baseline of intensity of bladder bother symptoms;   Change from baseline of quality of life;   Postvoid residual urine volume;   Upper urinary tract retention
17 Not yet recruiting Evaluation of Intravesical LP08 in Patients With Interstitial Cystitis/Painful Bladder Syndrome
Condition: Interstitial Cystitis
Interventions: Drug: LP-08 80mg;   Drug: Normal Saline Placebo;   Drug: LP-08 20mg
Outcome Measures: Safety;   Efficacy Voids Per Day (VPD);   Efficacy Global Response Assessment (GRA);   Efficacy Symptom;   Efficacy Visual Analog Scale (VAS);   Efficacy Diary
18 Recruiting Safety, Tolerability and Efficacy Study of LiRIS® 400mg in Women With Interstitial Cystitis
Condition: Interstitial Cystitis
Interventions: Drug: LiRIS 400 mg;   Other: LiRIS Placebo
Outcome Measure: Change from baseline in subject reported bladder pain on a numerical rating scale
19 Recruiting Observational Study of Hunner's Ulcer in Patient With Interstitial Cystitis/Bladder Pain Syndrome
Condition: Interstitial Cystitis
Outcome Measure: Change of distribution pattern of Hunner's ulcer
20 Recruiting Radiation Induced Cystitis Treated With Hyperbaric Oxygen - A Randomized Controlled Trial
Condition: Cystitis, Radio Induced
Intervention: Drug: Hyperbaric Oxygen
Outcome Measures: EPIC (Expanded Prostate cancer Index Composite);   Microscopic assessment;   RTOG (Radiation Toxicity Grade by Radiation Therapy Oncology Group);   SF-36 (Short Form Health Survey 36);   Adverse events

These studies may lead to new treatments and are adding insight into Cystitis etiology and treatment.

A major focus of Cystitis research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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