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Dapsone Medical Research Studies

Up-to-date List of Dapsone Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Dapsone Medical Research Studies

Rank Status Study
1 Unknown  Use of Dapsone Gel, 5% for Treating Dermatitis Herpetiformis
Condition: Dermatitis Herpetiformis
Intervention: Drug: Dapsone gel, 5%
Outcome Measures: Number and size of all lesions on the treated and untreated elbows or knees of patients with dermatitis herpetiformis who have one extremity treated with Dapsone gel, 5%;   Number of papules, plaques and vesicles on treated and untreated elbows or knees of patients who have one extremity treated with Dapsone gel, 5%;   Evaluation of clinical photographs and scoring of photographs based on a modified Global Acne Assessment Score
2 Unknown  Dapsone for Acute Ischemia Stroke Study
Conditions: Cerebral Stroke;   Cerebrovascular Accident, Acute;   Cerebrovascular Stroke;   Stroke, Acute;   Stroke
Interventions: Drug: Dapsone;   Drug: Placebo
Outcome Measures: Shift across the board of National Institute of Health stroke scale (NIHSS) and Modified Rankin Scale (mRS);   Barthel index
3 Not yet recruiting Dapsone Prurigo Study
Condition: Lichen Simples Chronicus and Prurigo
Intervention: Drug: Dapsone gel - verum
Outcome Measures: Pruritus based on visual analogue scale in side to side comparison;   5 D itch scale in side to side comparison
4 Recruiting Dermal Tolerability of Dapsone Gel in Healthy Volunteers
Condition: Healthy Volunteers
Interventions: Drug: Dapsone gel;   Drug: Dapsone gel vehicle;   Drug: sodium lauryl sulfate;   Drug: Normal saline
Outcome Measures: Mean Cumulative Irritation Index During Induction Phase;   Incidence of Sensitization Reactions During Challenge Phase
5 Recruiting Study of Prophylactic Topical Dapsone 5% Gel Versus Moisturizer for Cetuximab-induced Papulopustular (Acneiform) Rash in Patients With mCRC or HNSCC Without Previous or Concurrent RT
Conditions: Cetuximab-induced Papulopustular (Acneiform) Rash Who Have;   Metastatic Colorectal Cancer or Head and Neck Squamous Cell Carcinoma
Interventions: Drug: Topical Dapsone 5% Gel;   Other: Moisturizer;   Drug: oral antibiotics
Outcome Measure: difference in lesion counts
6 Recruiting Safety and Efficacy Study of Dapsone Gel in Patients With Acne Vulgaris
Condition: Acne Vulgaris
Interventions: Drug: Dapsone Gel;   Drug: Dapsone Gel Vehicle
Outcome Measures: Percentage of Patients with None or Minimal on the 5-Point Global Acne Assessment Score (GAAS) Scale;   Change from Baseline in Inflammatory Facial Lesion Counts;   Change from Baseline in Noninflammatory Facial Lesion Counts;   Change from Baseline in Total Lesion Counts;   Percentage Change from Baseline in Lesion Counts;   Percentage of Patients Reporting "Very Good" or "Excellent" in the Assessment of Facial Appearance on a 5-Point Scale;   Percentage of Patients Reporting at Least a 1-Grade Improvement from Baseline in Oiliness on a 5-Point Scale;   Percentage of Patients Reporting at Least a 1-Grade Improvement from Baseline in Redness on a 5-Point Scale;   Change from Baseline in the 9-Item Acne Symptom and Impact Scale (ASIS) Symptom Domain Total Score
7 Recruiting A Safety and Efficacy Study of Dapsone Gel in Patients With Acne Vulgaris
Condition: Acne Vulgaris
Interventions: Drug: Dapsone Gel;   Drug: Dapsone Gel Vehicle
Outcome Measures: Percentage of Patients with None or Minimal on the 5-Point Global Acne Assessment Score (GAAS) Scale;   Change from Baseline in Inflammatory Facial Lesion Counts;   Change from Baseline in Noninflammatory Facial Lesion Counts;   Change from Baseline in Total Lesion Counts;   Percentage Change from Baseline in Lesion Counts;   Percentage of Patients Reporting "Very Good" or "Excellent" in the Assessment of Facial Appearance on a 5-Point Scale;   Percentage of Patients Reporting at Least a 1-Grade Improvement from Baseline in Oiliness on a 5-Point Scale;   Percentage of Patients Reporting at Least a 1-Grade Improvement from Baseline in Redness on a 5-Point Scale;   Change from Baseline in the 9-Item Acne Symptom and Impact Scale (ASIS) Symptom Domain Total Score
8 Recruiting A Study of Dapsone Gel in Females With Skin of Color and Acne Vulgaris
Condition: Acne Vulgaris
Intervention: Drug: Dapsone Gel
Outcome Measures: Change from Baseline in the Global Assessment of Acne Severity (GAAS) Score by Physician;   Change from Baseline in Lesion Counts;   Percentage of Subjects with 0 (None) or 1 (Minimal) on the GAAS;   Change from Baseline in the Acne Symptom and Impact Scale (ASIS) Score;   Total Score for the ASIS Symptom Domain;   Total Score for the ASIS Impact Domain;   Change from Baseline in the GAAS
9 Recruiting Photoallergy Potential of Dapsone Gel in Healthy Volunteers
Condition: Healthy Volunteers
Interventions: Drug: Dapsone gel;   Drug: Dapsone gel vehicle
Outcome Measure: Photoallergic (Sensitizing) Potential Using a Visual Scale
10 Recruiting Phototoxicity Test of Dapsone Gel in Healthy Volunteers
Condition: Healthy
Interventions: Drug: Dapsone gel;   Drug: Dapsone gel vehicle
Outcome Measure: Phototoxicity Irritation Potential Using a Visual Scale
11 Recruiting Prospective Assessment of Meos Telemedicine E-portal on Ambulatory Care of Type 1 Diabetic Patients
Condition: Diabetes Mellitus, Type 1
Intervention: Device: Meos ePortal use
Outcome Measures: HbA1c measured at 12 months in Meos ePoral group versus conventional care group. Non-inferiority level is defined at a 0.15% threshold for an expected HbA1c of 8.5% at 12 months;   HbA1c measured at 6 months in each group;   HbA1c measured at 12 months in each group;   HbA1c measured at 6 months in each group according to initial HbA1c level (higher than 8% or to median);   HbA1c measured at 12 months in each group according to initial HbA1c level (higher than 8% or to median);   Definition of failure: study withdraws or emergency hospitalization linked to diabetes or HbA1c increase of 0.5 % up to 12 months of follow up;   Annual cost of diabetes care from hospital and health insurance' points of view;   Quality of life at inclusion and 12 months, using the Diabetes Health Profile (DHP-1) scale and the Satisfaction items of the Diabetes Quality of Life (DQOL) questionnaire;   Qualitative analysis by semi-structured interviews, then quantitative survey by questionnaire

These studies may lead to new treatments and are adding insight into Dapsone etiology and treatment.

A major focus of Dapsone research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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