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Daytime Medical Research Studies

Up-to-date List of Daytime Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Daytime Medical Research Studies

Rank Status Study
1 Recruiting A Double-Blind, Placebo-Controlled, Cross-over Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia
Conditions: Nocturia;   Daytime Sleepiness
Intervention: Drug: Armodafinil 50 - 250 mg pills
Outcome Measures: Change in Epworth Sleepiness Scale;   Clinical Global Impressions, change in severity of excessive Daytime sleepiness (EDS);   Number of naps;   Number of minutes napped based on sleep diary
2 Recruiting SWS And Daytime Functioning in Chronic FatiguE Syndrome (SAFFE)
Condition: Chronic Fatigue Syndrome
Interventions: Drug: Sodium Oxybate;   Other: placebo (fresh potable water)
Outcome Measures: EEG slow wave activity during sleep;   Daytime sleepiness
3 Recruiting Effects of Brain Stimulation During Daytime Nap on Memory Consolidation in Younger, Healthy Subjects
Condition: Healthy Subjects
Interventions: Device: brain stimulation;   Device: no stimulation
Outcome Measures: Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS;   Amount of Slow wave Sleep;   2. sleep spindles;   3. EEG-correlates;   4. further memory systems
4 Recruiting Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Patients With Mild Cognitive Impairment
Condition: Mild Cognitive Impairment, So Stated
Interventions: Device: SHAM stimulation;   Device: 0,75 Hz stimulation
Outcome Measures: Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS;   Amount of Slow wave Sleep, spindels, eeg-correlates, further memory systems
5 Recruiting Pitolisant to Assess Weekly Frequency of Cataplexy Attacks and EDS in Narcoleptic Patients (HARMONY CTP)
Conditions: Narcolepsy With Cataplexy;   Excessive Daytime Sleepiness
Interventions: Drug: Pitolisant;   Drug: Placebo
Outcome Measures: Measure of anticataplectic efficacy;   Excessive Daytime Sleepiness assessment;   Safety assessment
6 Recruiting Topical 3% Amphotericin B Cream for the Treatment of Cutaneous Leishmaniasis in Colombia
Condition: Cutaneous Leishmaniasis
Intervention: Drug: Topical Amphotericin B at 3%
Outcome Measures: Proportion and severity of local adverse events of Anfoleish or Vehicle when applied three or two times per day.;   Clinical cure rates in two regimens of Anfoleish: Three times a day and Two times a day;   Determination of Amphotericin B Cmax and Tmax in subjects treated with Anfoleish three or two times per day.;   Proportion and severity of laboratory adverse events of Anfoleish or vehicle when applied three or two times per day
7 Recruiting Diurnal Variation of Mineral Metabolism and Protein Fermentation Metabolites in Peritoneal Dialysis Patients and Healthy Volunteers
Condition: Peritoneal Dialysis
Intervention:
Outcome Measure: To evaluate the diurnal variation of serum concentrations of phosphate and protein fermentation metabolites in healthy volunteers as compared to dialysis patients.
8 Recruiting Non-invasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) Using the iVAPS Mode
Condition: Amyotrophic Lateral Sclerosis (ALS)
Intervention: Device: Non-invasive home ventilation
Outcome Measures: Difference in the number of respiratory therapist interventions required using IVAPS vs BIST mode of ventilation in patients with ALS.;   Feasibility of initiating long term home ventilation in ALS patients using the Stellar 150 iVAPS mode during a single Daytime trial.;   Difference in symptoms with IVAPS vs. BiST in ALS patients;   Effectiveness of ventilation by IVAPS vs. BiST on night-time respiratory parameters in ALS patients;   Long-term compliance with the use of nocturnal ventilation on IVAPS vs. BiST in ALS patients
9 Not yet recruiting Comparing Diurnal Fluctuations in Intra Ocular Pressure Measured in Same Day Versus Different Days in Glaucoma Patients
Condition: Glaucoma
Intervention:
Outcome Measure: IOP at different times of the day at same day versus different times and different days
10 Recruiting Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Older Adults
Condition: Older Adults (50-80 Years)
Interventions: Device: brain stimulation;   Device: Sham Stimulation
Outcome Measures: Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS;   1. Amount of Slow wave Sleep;   2. sleep spindels;   3. EEG-correlates;   4. further memory systems
11 Recruiting Arterial Stiffness in Chronic Kidney Disease
Condition: Chronic Kidney Disease
Intervention:
Outcome Measures: Diurnal variations in arterial stiffness;   Diurnal variations in aortic and brachial blood pressure;   Relationship between changes in blood pressure and arterial stiffness
12 Unknown  Comparison of RT in Patients With Sleep Apnea With and Without Complaints of Daytime Sleepiness
Condition: Sleep Apnea
Intervention:
Outcome Measure:
13 Unknown  Cardiovascular Consequences of NIV Withdrawal in Patients With Myotonic Dystrophy
Condition: Myotonia
Intervention: Other: withdrawal of non-invasive ventilation
Outcome Measures: To evaluate endothelial dysfunction (as measured by Peripheral arterial tone (PAT)) and its evolution after four weeks withdrawal of non-invasive ventilation (NIV).;   To assess arterial stiffness, systemic inflammation (IL6, TNFα, Leptin, CRP), insulin resistance, DHEA, sleep quality, objective and subjective Daytime somnolence and their evolution after four weeks withdrawal of NIV.
14 Recruiting ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.
Conditions: Heart Failure;   Obstructive Sleep Apnea;   Central Sleep Apnea
Intervention: Other: [C11]Acetate and HED PET
Outcome Measures: ASV therapy yields a reduction in the rate of oxidative metabolism as measured by [11C]acetate kinetics using PET imaging in patients with HF, OSA and/or CSA;   ASV therapy yields an improvement in energy transduction from oxidative metabolism to stroke work as measured by an increase in the Daytime work-metabolic index inpatients with HF, OSA and/or CSA.;   ASV for CSA or OSA in patients with HF and sleep apnea will normalize Daytime myocardial SN pre-synaptic function measured by [11C]HED retention on PET imaging,;   ASV for CSA or OSA in patients with HF and sleep apnea will normalize Daytime sympathetic contributions to heart rate variability
15 Recruiting Gene Expression in the Overactive Bladder in Children
Conditions: Overactive Bladder;   Children
Intervention:
Outcome Measure: Up- and down regulation of genes expressed in the bladder
16 Recruiting Diurnal Changes of the Cornea - a Pilot Study
Condition: Astigmatism
Intervention:
Outcome Measures: Descriptive analysis of diurnal changes of the corneal radii (in diopters) and orientation of the steep meridian (in degrees) in young healthy subjects and elderly patients;   Comparison of the corneal radii (in diopters) and orientation of the steep meridian (in degrees) between different measuring devices
17 Unknown  Comparing Fluticasone-Salmeterol in Chronic Obstructive Pulmonary Disease (COPD) and Sleep
Condition: COPD
Interventions: Drug: fluticasone/salmeterol 250/50;   Drug: placebo
Outcome Measures: The aim of this study is to determine the effect of fluticasone/salmeterol on sleep quality in patients with COPD and to compare efficacy of Advair 250 compared to placebo on sleep.;   Daytime somnolence
18 Recruiting Behavioral Treatment of Menopausal Insomnia; Sleep and Daytime Outcomes
Condition: Menopause
Interventions: Behavioral: Cognitive Behavioral Therapy for Insomnia;   Behavioral: Sleep Education;   Behavioral: Sleep Restriction Therapy
Outcome Measures: Sleep;   Depression;   Quality of life
19 Recruiting Non-invasive Haemodynamic Assessment in Hypertension
Condition: Arterial Hypertension
Interventions: Drug: lisinopril;   Drug: Telmisartan;   Drug: Nebivolol;   Drug: Indapamide/hydrochlorothiazide;   Drug: Amlodipine
Outcome Measures: 24-h mean Systolic Blood Pressure (in ABPM);   24-h mean Diastolic Blood Pressure (in ABPM);   Daytime mean Systolic Blood Pressure (in ABPM);   Daytime mean Diastolic Blood Pressure (in ABPM);   night-time mean Systolic Blood Pressure (in ABPM);   night-time mean Diastolic Blood Pressure (in ABPM);   Systolic Blood Pressure (in OBPM);   Diastolic Blood Pressure (in OBPM);   change from baseline in Systolic Blood Pressure (in OBPM) at 3 months;   change from baseline in Diastolic Blood Pressure (in OBPM) at 3 months;   change from baseline in 24-h Systolic Blood Pressure (in ABPM) at 3 months;   change from baseline in 24-h Diastolic Blood Pressure (in ABPM) at 3 months;   change from baseline in Daytime Systolic Blood Pressure (in ABPM) at 3 months;   change from baseline in Daytime Diastolic Blood Pressure (in ABPM) at 3 months;   change from baseline in night-time Systolic Blood Pressure (in ABPM) at 3 months;   change from baseline in night-time Diastolic Blood Pressure (in ABPM) at 3 months
20 Recruiting Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone
Conditions: Polycystic Ovary Syndrome;   Hyperandrogenism
Interventions: Drug: Progesterone;   Drug: Placebo
Outcome Measures: Average luteinizing hormone (LH) interpulse interval and the total number of LH pulses;   Hourly hormone measurements during sampling period.

These studies may lead to new treatments and are adding insight into Daytime etiology and treatment.

A major focus of Daytime research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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