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Delayed Medical Research Studies

Up-to-date List of Delayed Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Delayed Medical Research Studies

Rank Status Study
1 Recruiting AV Delay Optimization vs. Intrinsic Conduction in Pacemaker Patients With Long PR Intervals
Conditions: Atrioventricular Block;   Sick Sinus Syndrome;   Symptomatic Bradycardia
Interventions: Device: Long, fixed AV delay;   Device: Short, optimized AV delay
Outcome Measures: Change in cardiac output determined by echocardiography;   Changes in functional status determined by 6 minute walk.;   Changes in sense of well being as determined by Short Form - 36 Medical Outcomes Study Questionnaire
2 Recruiting Placebo-Controlled Study to Evaluate the Safety and Efficacy of OPN-305 in Preventing Delayed Renal Graft Function
Condition: Delayed Renal Graft Function
Intervention: Drug: OPN-305
Outcome Measures: Incidence of Delayed Graft Function (dDGF);   Functional Delayed Graft Function (fDGF);   Serum creatinine at day 7 and 6 months;   Iohexol clearance at day 7 and 6 months;   Composite endpoint;   Time to biopsy-proven kidney allograft rejection;   Time to first dialysis and DGF duration;   Blood and urine biomarkers for acute kidney injury (AKI);   Duration of initial hospitalization;   Number of subsequent readmissions;   Duration of subsequent readmissions;   Reason for subsequent readmissions;   Number of Adverse events (AEs);   Nature of Adverse events (AEs);   Incidence of infections;   Rate of primary non-function (permanent lack of function of the allograft);   Incidence of the initiation of dialysis between 7 and 30 days post-transplantation
3 Recruiting Prophylactic Salpingectomy With Delayed Oophorectomy
Condition: Ovarian Carcinoma
Interventions: Other: Ovarian Cancer Screening;   Procedure: Prophylactic Salpingectomy with Delayed Oophorectomy;   Procedure: Risk-Reducing Salpingo-Oophorectomy;   Behavioral: Questionnaire;   Procedure: Transvaginal Ultrasound;   Behavioral: Phone Call
Outcome Measure: Patient Compliance with Prophylactic Salpingectomy with Delayed Oophorectomy Strategy
4 Recruiting Effect of Delayed Remote Ischemic Preconditioning on Myocardial Injury
Condition: Myocardial Injury
Interventions: Procedure: Delayed remote ischemic preconditioning;   Procedure: control
Outcome Measures: Troponin I change;   serum creatinine changes
5 Recruiting Adequate Definition of Delayed Graft Function in Living and Deceased Donor Kidney Transplantation
Conditions: Deceased Donor Kidney Transplantation;   Living Donor Kidney Transplantation
Intervention: Procedure: kidney transplantation, living or deceased donor
Outcome Measures: Delayed graft function as defined by dialysis requirements within one week after transplantation;   Delayed graft function as defined by urine output less than1200 ml during first day after transplantation;   Delayed graft function as defined by serum creatinine decrease less than 10% during 48 hours after transplantation;   Delayed graft function as defined by creatinine greater than 2.5 mg/dL at ten days after transplantation;   Delayed graft function as defined by creatinine clearance less than 10 ml/min/1.73m2 during 24 hours after transplantation;   Delayed graft function as defined by creatinine did not decrease less than preoperative value
6 Not yet recruiting Early Conversion From CNI to Belatacept in Renal Transplant Recipients With Delayed and Slow Graft Function
Conditions: Delayed Graft Function;   Kidney Transplant
Interventions: Drug: Belatacept;   Drug: Calcineurin Inhibitor
Outcome Measures: cGFR;   Renal Histology;   Biomarker profile;   Duration of Delayed (or slow) Graft Function;   Incidence of Acute Rejection;   New Onset Diabetes;   Blood Pressure Control;   Dyslipidemia;   Graft Survival;   Patient survival
7 Recruiting Belatacept for Renal Transplant Recipients With Delayed Graft Function
Condition: Delayed Graft Function
Interventions: Drug: Belatacept;   Drug: Everolimus
Outcome Measures: Time to recover from Delayed Graft Function;   Percent patients reaching recovery (defined above) by 14 days and 3 months.;   Hospital length of stay (days) from date of transplant to discharge;   Number of dialysis treatments;   Number of biopsies;   Biopsy proven acute rejection events;   Patient and graft survival;   Number of hospital readmissions;   Detection of DSA (Luminex);   Incidence and type of infection;   Measured or estimated creatinine clearance.;   Banff score of rejection episodes and immune suppression treatment/management of rejection;   Immune suppression drug levels (everolimus or sirolimus, cyclosporine, or mycophenolate as clinically monitored).
8 Recruiting The PREMOD Trial: A Randomized Controlled Trial of Umbilical Cord Milking vs. Delayed Cord Clamping in Premature Infants
Condition: Intraventricular Hemorrhage
Interventions: Procedure: Umbilical Cord Milking;   Procedure: Delayed Cord Clamping
Outcome Measures: Superior Vena Cava Flow;   Delivery Room Interventions;   Hemoglobin;   Neurodevelopmental impairment 18-36 months;   Severe intraventricular hemorrhage (grade 3 or 4);   Phototherapy;   Ionotropic support;   Neonatal intensive care unit (NICU) length of stay;   Necrotizing enterocolitis;   Number of blood transfusions while in the neonatal intensive care unit;   Ventilator time;   Apgar score <7 at 5 minutes;   Umbilical cord pH < 7.0;   Blood pressure in first 2 hours of admission to neonatal intensive care unit;   Polycythemia;   Neonatal death;   Use of uterotonic agents;   Peak transcutaneous and/or serum bilirubin concentrations;   Maternal hemoglobin;   Intraventricular Hemorrhage detected on Head Ultrasound
9 Recruiting A Study of the Activity of Eculizumab for Prevention of Delayed Graft Function In Deceased Donor Kidney Transplant
Condition: Delayed Function of Renal Transplant
Interventions: Drug: Eculizumab;   Drug: Placebo
Outcome Measure: Composite of Delayed Graft Function and Slow Graft Function
10 Unknown  Tacrolimus to Sirolimus Conversion for Delayed Graft Function
Conditions: Kidney Transplant;   Delayed Graft Function;   Slow Graft Function-defined at Creatinine >= 3.0 by Post-op Day 5 Without Requiring Dialysis
Interventions: Drug: Tacrolimus (FK506, Prograf);   Drug: Sirolimus (Rapamune, Rapamycin)
Outcome Measures: The composite endpoint of reduction of e eGFR at one year by more than 15% & the progression in fibrosis score at one year by >=20% compared with the baseline values;   eGFR;   Change in eGFR from baseline to 1-year;   Graft survival (Actual, Actuarial);   Patient survival (Actual and Actuarial);   Incidence & severity of acute rejection (Actual, Actuarial);   Incidence of development of DSA;   Incidence of BK nephropathy (Cumulative);   Change in inflammatory markers (including IL-6, MCP, CRP)from baseline
11 Unknown  Delayed Cord Clamping in Premature Infants
Conditions: Hypothermia;   Anemia
Intervention: Other: Delayed cord clamping
Outcome Measures: Initial body temperature;   Hematocrit at birth and 24 hours of age
12 Recruiting Short Course Radiotherapy and mFOLFOX6 With Delayed Surgery for Rectal Cancer With Synchronous Distant Metastasis
Conditions: Rectal Cancer;   Liver Metastasis;   Lung Metastasis
Intervention: Radiation: SCRT and mFOLFOX6 with Delayed surgery
Outcome Measures: R0 resection rate;   Overall survival rate;   Progression free survival rate;   Tumor regression grade;   Toxicity
13 Recruiting Phase 1/2a Study on Allogeneic Osteoblastic Cells Implantation in Delayed-Union Fractures
Condition: Long Bone Delayed-Union
Intervention: Drug: ALLOB® Implantation
Outcome Measures: Percentage of patients having a rescue surgery;   Global Disease Evaluation using a Visual Analogue Scale;   Radiological healing progression as assessed by CT scan;   Potential occurrence of any AE or SAE, related to the product or to the procedure, using patient open non-directive questionnaire, physical examination and laboratory measurements;   Pain using a Visual Analogue Scale;   Weight-bearing using Likert Scale;   Radiological healing progression as assessed by X-ray;   Cell biodistribution after implantation (sub-study) as assessed by SPECT/CT scan
14 Unknown  A Prospective Randomized Controlled Multicenter Trial of Delayed Gastric Emptying (DGE) After Pancreaticoduodenectomy Evaluating by Gastrointestinal Reconstruction
Condition: Postprocedural Delayed Gastric Emptying
Interventions: Procedure: Retrocolic gastro- or duodeno- jejunostomy in hte pancreaticoduodenectomy;   Procedure: Antecolic gastro- or duodeno- jejunostomy in the pancreaticoduodenectomy
Outcome Measure: Incident rate of Delayed gastric emptying
15 Recruiting Eculizumab for Prevention of Delayed Graft Function (DGF) in Kidney Transplantation
Conditions: Delayed Graft Function;   Kidney Transplant;   Complement Activity
Interventions: Drug: Eculizumab;   Drug: Normal Saline
Outcome Measures: Hemodialysis;   Estimated Glomerular Filtration Rate (GFR);   Primary Non-function;   Graft Rejection;   Patient Survival;   Graft Survival;   Serum Creatinine;   Urine Output;   Biomarkers
16 Recruiting Acute Cholecystitis: Early Versus Delayed Laparoscopic Cholecystectomy; Randomized Prospective Study
Condition: Acute Cholecystitis
Interventions: Procedure: Early cholecystectomy;   Procedure: Delayed cholecystectomy
Outcome Measures: Operative time;   Perioperative complications;   Conversion rate;   hospital stay in days;   Period of giving antibiotics in days
17 Recruiting Acute vs. Delayed Iron: Effect on Red Cell Iron Incorporation in Severe Malaria
Conditions: Iron Deficiency;   Malaria;   Nutrition;   Global Health
Intervention: Dietary Supplement: Ferrous sulfate syrup; iron stable isotope 57Fe; iron stable isotope 58Fe
Outcome Measures: Percent red blood cell iron incorporation on Day 0 in children in the immediate group vs. percent red blood cell iron incorporation on Day 28 in children in the Delayed group;   Hematological recovery in the immediate vs. Delayed groups on Day 56
18 Recruiting High Dose Versus Low Dose Oxytocin for Augmentation of Delayed Labour
Condition: Birth; Delayed
Intervention: Drug: Syntocinon
Outcome Measures: Caesarean delivery rate;   Spontaneous vaginal birth rate;   Length of labour;   Hyper-stimulation of contractions;   Postpartum haemorrhage;   Sphincter lacerations;   Epidural analgesia;   Experienced labour pain;   Childbirth experience;   Apgar score;   Neonatal intensive care
19 Recruiting Efficacy of Delayed Coloanal Anastomosis for Medium and Lower Rectum Cancer Treatment. Phase 2 Clinical Trial (CASCADOR)
Condition: Medium and Lower Rectal Cancer
Interventions: Procedure: Delayed coloanal anastomosis (ACAD);   Procedure: ACAI Group (coloanal anastomosis Immediate)
Outcome Measures: Main objective is to evaluate effectiveness of Delayed coloanal anastomosis (ACAD) in the medium and lower rectal cancer treatment,;   The number of stomata bypass (preventive or therapeutic) will be evaluated.;   Morbidity will be assessed;   Postoperative mortality will be assessed during the first 30 days of the date of surgery.;   Progression-free survival will be assessed at 1 and 2 years;   A functional evaluation will be conducted in the month before the surgery as well as 6 months, 1 year and 2 years after surgery
20 Unknown  Prevalence of Atrial Delay That Would Preclude Optimization of Atrioventricular (AV) Delay in Patients With Biventricular (BiV) Device
Condition: Heart Failure
Intervention:
Outcome Measure: to determine the proportion of patients who are undergoing Biventricular (BiV) Implantable Cardioverter Defibrillator (ICD) implantation in whom optimization of atrioventricular (AV) delay is not possible due to prolonged inter-atrial/intra-atrial delay.

These studies may lead to new treatments and are adding insight into Delayed etiology and treatment.

A major focus of Delayed research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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