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Desipramine Medical Research Studies

Up-to-date List of Desipramine Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Desipramine Medical Research Studies

Rank Status Study
1 Recruiting Pilot Study of the Effects of the Desipramine on the Neurovegetative Parameters of the Child With Rett Syndrome
Condition: Rett Syndrome
Interventions: Drug: Administration of a high dose of Desipramine;   Drug: Administration of a low dose of Desipramine;   Drug: Administration of a placebo
Outcome Measures: To study the efficacy of the Desipramine on the respiratory disturbations;   To study the safety of the Desipramine in the studied population
2 Recruiting Desipramine Hydrochloride and Filgrastim For Stem Cell Mobilization in Patients With Multiple Myeloma Undergoing Stem Cell Transplant
Conditions: Refractory Multiple Myeloma;   Stage I Multiple Myeloma;   Stage II Multiple Myeloma;   Stage III Multiple Myeloma
Interventions: Drug: Desipramine hydrochloride;   Biological: filgrastim;   Other: laboratory biomarker analysis
Outcome Measures: Success rate of stem cell mobilization (SCM) using filgrastim and Desipramine to collect > 5 x 10^6 cluster of differentiation (CD)34/kg in patients with multiple myeloma (MM) who are first time mobilizers or unexposed to alkylating agents;   Success rate of SCM using filgrastim and Desipramine to achieve a total collection of > 5 x 10^6 CD34/kg in patients with MM who failed prior mobilization or were exposed to alkylator therapy or are predicted to be difficult to mobilize;   Average number of days of apheresis required to collect > 5 x 10^6 CD34+/kg;   Incidence of adverse events graded by the National Cancer Institute Common Terminology Criteria for Adverse Events version 4;   Time to neutrophil engraftment: first of three consecutive days with absolute neutrophil count (ANC) > 500/ul or first day with ANC > 1000/ul in the absence of growth factor support;   Time to platelet engraftment: first of three days of platelets > 20,000/ul without transfusion
3 Recruiting Risperidone and Desipramine in Alcohol Use and Schizophrenia
Conditions: Schizophrenia;   Alcoholism;   Dual Diagnosis
Interventions: Drug: Risperidone + Desipramine;   Drug: Risperidone + Placebo
Outcome Measure: Timeline Followback
4 Unknown  Irritable Bowel Syndrome (IBS) Functional Magnetic Resonance Imaging (fMRI) With Desipramine
Condition: Irritable Bowel Syndrome
Intervention: Drug: Desipramine
Outcome Measure: Changes in brain activations using functional MR following Desipramine therapy in IBS populations.
5 Recruiting Efficacy of Antidepressants in Chronic Back Pain
Condition: Back Pain
Interventions: Behavioral: cognitive behavioral therapy;   Drug: Desipramine hydrochloride;   Drug: benztropine mesylate 0.125 mg daily
Outcome Measures: Descriptor Differential Scale of pain intensity;   Roland and Morris Disability
6 Recruiting A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors
Condition: GERD
Interventions: Device: Nissen fundoplication;   Drug: baclofen;   Drug: Desipramine
Outcome Measures: The primary outcome measure will be the gastroesophageal reflux disease health-related quality of life (GERD-HRQL) index, a validated instrument that has been used to assess the response of GERD to treatments with medications, endoscopic procedures and s;   1.To determine the frequency with which non-GERD disorders underlie "PPI failure" in patients who have persistent heartburn while on PPIs.;   2.To determine the frequency of functional gastrointestinal symptoms, anxiety and depression in patients who have persistent heartburn while on PPIs.;   3.To determine whether functional gastrointestinal symptoms, anxiety and depression is associated with the outcomes of medical and surgical therapies for patients who have persistent heartburn while on PPIs.;   4.To determine whether the outcome of Nissen fundoplication for patients who have persistent heartburn while on PPIs is associated with adherence to technical aspects of the operation.
7 Unknown  Tricyclic Antidepressants (TCAs) on Gastric Emptying
Condition: Functional Dyspepsia
Interventions: Drug: Desipramine;   Drug: Amitriptyline
Outcome Measures: Gastric emptying;   Gastric volume
8 Recruiting Linking Altered Central Pain Processing and Genetic Polymorphism to Drug Efficacy in Chronic Low Back Pain (Predictio)
Condition: Low Back Pain
Interventions: Drug: Oxycodone 15mg;   Drug: Clobazam;   Drug: Imipramine;   Drug: Tolterodine
Outcome Measures: Difference in NRS(pain scale) between measurement after and before drug administration;   Patients global impression of change scale after drug administration;   Pharmacogenetic variables(see before);   Pharmacokinetics: measure of Imipramine and Desipramine blood levels;   Reliability of repeated quantitative sensory testing in the same patient
9 Recruiting Comparison Of 2 Doses Of Temsirolimus (Torisel) In Patients With Mantle Cell Lymphoma
Condition: Non-Hodgkin's Lymphoma (NHL)
Intervention: Drug: temsirolimus
Outcome Measures: Estimate independently assessed Progression Free Survival (PFS);   Estimate Overall survival;   Estimate objective response rate;   Estimate PFS per investigator;   Assess safety, including infection and bleeding;   Quantify potential of temsirolimus to alter disposition of Desipramine, a substrate of CYP2D6 metabolism

These studies may lead to new treatments and are adding insight into Desipramine etiology and treatment.

A major focus of Desipramine research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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