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Diabetic Ulcer Medical Research Studies

Up-to-date List of Diabetic Ulcer Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Diabetic Ulcer Medical Research Studies

Rank Status Study
1 Not yet recruiting Hyperbaric Oxygenation in Diabetic Ulcer
Condition: Diabetes Mellitus
Intervention: Drug: Hyperbaric oxygen
Outcome Measures: ICG (indocyanine green) video angiography;   High performance 3D LifeViz™ system
2 Recruiting Effect of Topic Pirfenidone in Diabetic Ulcers
Condition: Diabetic Foot Ulcers
Interventions: Drug: Pirfenidone;   Procedure: Debridement
Outcome Measure: Ulcer size
3 Recruiting A Prospective, Open Label Safety Trial of the RedDress Wound Care System (RD1) in Management of Texas 1a or 2a Neuropathic Diabetic Foot Ulcers.
Condition: Neuropathic Diabetic Ulcer - Foot
Intervention: Device: RedDress Wound Care System (RD1)
Outcome Measures: Adverse event rate;   Complication rate due to lack of venous access;   Incidence of complete wound closure at 12 weeks;   Percent reduction in wound size over 12 weeks (ITT population);   Associations between lack of healing and patient/wound parameters (ITT population)
4 Unknown  Use of Fish Skin Extracellular Matrix (ECM) to Facilitate Chronic Wound Healing
Conditions: Pressure Ulcers;   Venous Ulcers;   Diabetic Ulcers;   Chronic Ulcer of Foot;   Trauma-related Wound
Intervention: Device: Marigen Wound Dressing
Outcome Measures: Wound healing;   Wound granulation
5 Unknown  Local Application of Autologous Bone Marrow Cells for Treatment of Chronic Diabetic Ulcers
Conditions: Diabetic Foot;   Diabetes Complications
Intervention: Procedure: Application of autologous bone marrow
Outcome Measures: Safety and Feasibility;   Healing velocity
6 Recruiting Nerve Decompression for Ulcer Recurrence Avoidance (DURA)
Conditions: Diabetic Ulcer of Plantar Aspect of Left Foot;   Diabetic Ulcer of Plantar Aspect of Right Foot;   Diabetic Polyneuropathy
Intervention: Procedure: nerve decompression
Outcome Measures: occurrence of plantar foot ulceration wound;   occurrence of delayed wound healing;   Visual Analog Pain Score
7 Recruiting Safety and Efficacy Study of HO/03/03 10-40 Micro Grams to Treat Hard to Heal Wounds
Condition: Hard to Heal Wounds
Intervention: Drug: HO/03/03 10-40 µg
Outcome Measures: Time to Heal;   Wound closure
8 Not yet recruiting Endogenous Progenitors Cell Therapy for Diabetic Foot Ulcers
Condition: Diabetic Ulcer
Intervention: Drug: AMD3100 injection + rhPDGF-BB topical
Outcome Measures: Rate of Wound Closure;   Quality of Life;   Glycosylated hemoglobin (HbA1C);   capillary blood glucose (ACCUCHEK Finger Stick);   Transcutaneous oxygen tension measurements on wound and 1 cm-radius periphery (Radiometer adult sensor);   Ankle-brachial index (ABI, Prestige sphygmomanometer and Summit doppler probe);   pain (Visual-Analog Scale);   temperature of surrounding skin in a 1 cm-radius around the DFU (TempTouch Dermal Thermometer);   sensation (Nk Pressure-Specified Sensory Device);   photogrammetry (Photoshop CS3, Adobe Systems);   glomerular filtration rate (GFR, estimated by 24 hr. urine creatinine measurement);   diabetic retinopathy (digital ophthalmologic examination);   cEPCs by FACS analysis
9 Not yet recruiting Clinical Trial to Evaluate Blister Graft Utilizing a Novel Harvesting Device for Treatment of Venous Leg Ulcers
Conditions: Impaired Wound Healing;   Venous Insufficiency of Leg;   Diabetic Ulcers
Intervention: Device: Harvesting Device (CelluTome©)
Outcome Measures: Time to healing in patients treated with epidermal grafting and standard of care vs. standard of care alone.;   Percentage of venous leg ulcers that have healed each week.;   Cost effectiveness of epidermal grafting versus standard of care.;   Incidence of adverse events with epidermal grafting versus standard of care.;   Correlation between protease level and healing rate.;   Pain scores as reported by subjects.
10 Recruiting Treatment of PRP on Diabetes Wound
Condition: Diabetic Ulcers on Both Feet
Intervention: Other: wound healing
Outcome Measure: effect of PRP on diabete wound closure
11 Recruiting HELP-Apheresis in Diabetic Ischemic Foot Treatment (H.A.D.I.F)
Conditions: Foot Ulcers;   Arteriosclerosis Obliterans;   Diabetes Mellitus
Intervention: Device: LDL-apheresis
Outcome Measures: Proportion of subjects obtaining the ulcer healing (Class 0A according to TEXAS classification) after 12 month from the study starts.;   Improvement of the peripheral oxygenation evaluated by means of transcutaneous oximetry measurement at foot level: TcP O2 (mmHg).;   Evaluation of pain level variation (verbal numeric range; score from 1 to 10);   Lowering of circulating inflammation markers (C Reactive Protein, Fibrinogen). CRP plasmatic concentration (mg/L) and fibrinogen (g/L);   Rate of cardiovascular events in the observation period (1-year follow-up).;   proportion of subjects with minor amputation (only toe or part of the foot removed)- in agreement with the approved amendment;   proportion of subjects with major amputation (these are usually below the knee or above the knee)- in agreement with the approved amendment
12 Recruiting Comparison of Resin Salve and Octenidine in Patients With Neuropathic Diabetic Foot Ulcers
Conditions: Diabetes Mellitus;   Diabetes Complications;   Diabetic Neuropathies;   Wound Infection
Interventions: Device: Resin salve treatment;   Device: Octenidine treatment
Outcome Measures: Wound healing;   Eradication of bacteria
13 Recruiting Allogenic Dermis Versus Standard Care in the Management of Diabetic Foot Ulcers
Condition: Diabetic; Foot Ulcers
Interventions: Other: Offloading;   Other: Dressing Application
Outcome Measures: proportion of ulcers completely healed by the allogenic dermal graft protocol of care to the standard protocol of care in the management of indolent Diabetic Ulcers at 6 weeks;   Compare the proportion of ulcers completely healed at 4 weeks;   Compare the proportion of ulcers completely healed at 12 weeks;   Mean time to healing
14 Unknown  Bioburden Reduction of Diabetic Foot Ulcer
Condition: Diabetic Foot Ulcer
Intervention: Device: Noveon laser
Outcome Measure: Decrease of Bioburden Effect In diabetic Foot Ulcer
15 Unknown  Evaluation of Windowed Casts With and Without Regranex® Gel for Healing Diabetic Neuropathic Ulcers
Condition: Diabetic Foot Ulcers
Interventions: Drug: Regranex®;   Drug: Hydrogel
Outcome Measure: Completely healed wounds
16 Recruiting The Therapeutical Role of Continuous Intra-femoral Artery Infusion of Urokinase on Diabetic Foot Ulcers
Condition: Diabetic Foot Ulcer
Interventions: Drug: continuous intra-femoral thrombolysis group;   Drug: Conventional therapy group
Outcome Measures: healing rate of diabetic foot ulcers;   The recurrence rate of diabetic foot ulcers;   cardiovascular events during the follow up period
17 Recruiting Randomized, Prospective Evaluation of the Toad Brace in Plantar Ulcer Off-loading and Healing
Conditions: Diabetic Foot;   Pedal Ulcers
Interventions: Device: Optimal Medical Therapy Debridement + Toad Brace;   Other: Optimal Medical Therapy - Debridement
Outcome Measure: Change from baseline measured wound area
18 Not yet recruiting Laser Therapy for Onychomycosis in Patients Wih Diabetes at Risk for Diabetic Foot Complications
Condition: Onychomycosis
Interventions: Device: Nd:YAG laser pulse therapy;   Device: Sham procedure
Outcome Measures: complete cure of the target nail;   Microbiological cure of the target nail;   Complete clinical cure of the target nail;   Markedly clinically improved target nail;   Onychomycosis severity index below 6 (in patients with scores >6 at study entry) of the target nail;   Complete clinical cure of all affected toes;   Change in quality of life;   Change surface healthy target nail / all clinically infected toes patients free of hyperkeratosis
19 Unknown  Trial of exSALT SD7™ Compared to Xeroform® Petrolatum Dressing for the Management of Partial Thickness Donor Sites
Conditions: Wound Healing;   Wound Infection
Interventions: Device: The exSALT™ SD7 Wound Dressing;   Device: Xeroform® Petrolatum Dressing
Outcome Measures: Evaluate the proportion of donor sites healed.;   Time to re-epithelialization.;   Pain with dressing changes and mobilization.;   Assessments that quantify ease of use.;   Resource utilization and safety.;   Appearance and long term cosmetic results.
20 Recruiting Phase IV Study to Evaluate the Efficacy of AMNIOEXCEL in Diabetic Foot Ulcers
Condition: Diabetic Foot Ulcers
Interventions: Other: AMNIOEXCEL;   Other: Standard of Care, Diabetic Foot Ulcers
Outcome Measures: Proportion of patients with complete wound closure (i.e. complete skin re-epithelialization without drainage or dressing requirements) at 6 weeks after initiation of study treatment;   Time to complete wound closure of the target ulcer;   Rate of wound closure;   Incidence, severity and type of adverse events;   Changes in Quality of Life assessment

These studies may lead to new treatments and are adding insight into Diabetic Ulcer etiology and treatment.

A major focus of Diabetic Ulcer research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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