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Diazoxide Medical Research Studies

Up-to-date List of Diazoxide Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Diazoxide Medical Research Studies

Rank Status Study
1 Unknown  Use of Diazoxide in Acute Hypoglycaemia
Condition: Type 1 Diabetes
Interventions: Drug: Diazoxide;   Drug: Placebo
Outcome Measures: Adrenaline response(pmol/L) at 2.5mmol/L of glucose;   Glucose Thresholds (calculated when hormone release is greater than 2SD of hormone level at euglycaemia 4.0mmol/L blood sugar) of each of the counter-regulatory hormones (adrenaline, noradrenalin, glucagon)
2 Unknown  Diazoxide In the Management Of Hypoglycemic Neonates
Conditions: Infant, Newborn, Diseases;   Pregnancy in Diabetics;   Infant, Diabetic Mother;   Hypoglycemia;   Infant, Large for Gestational Age
Interventions: Drug: Diazoxide;   Drug: Ora-plus
Outcome Measures: Blood glucose measurement less than 2.0mmol/L;   Number of infants with significantly low blood glucose measurements (<1.5mmol/L).;   Length of stay for infants in hospital;   Need for intravenous dextrose infusion to maintain blood glucose above 2.0mmol/L;   Admission to neonatal intensive care unit (NICU);   Thrombocytopenia and/or Leukopenia;   Electrolyte imbalance requiring clinical intervention (intravenous or oral)
3 Unknown  Open-Label, Single- and Multiple-Dose Pharmacokinetic Study of Diazoxide Choline
Condition: Hypertriglyceridemia
Interventions: Drug: Diazoxide choline;   Drug: Diazoxide choline high dose
Outcome Measures: Compare the single-dose and steady-state, fed and fasting PK profiles of two dose levels of Diazoxide administered as DCCR;   Assess the impact of dosing in the absence of food on the steady-state pharmacokinetic profiles of two dose levels of Diazoxide administered orally as DCCR under fed conditions
4 Unknown  DZX Mediated Insulin Suppression in Obese Men
Condition: Obesity
Interventions: Drug: Placebo;   Drug: Diazoxide;   Drug: Metformin + Diazoxide
Outcome Measure:
5 Recruiting Clinical Study of Diazoxide Choline Controlled-Release Tablet (DCCR) in Patients With Prader-Willi Syndrome
Condition: Prader-Willi Syndrome
Interventions: Drug: DCCR;   Drug: Placebo
Outcome Measures: Hyperphagia using hyperphagia questionnaire;   Resting energy expenditure
6 Unknown  Diazoxide Choline Controlled-Release Tablet (DCCR) for Very High Triglycerides
Condition: Hypertriglyceridemia
Interventions: Drug: 290 mg DCCR;   Drug: 435 mg DCCR;   Drug: 135 mg fenofibric acid;   Drug: Placebo;   Drug: atorvastatin
Outcome Measures: The effect of DCCR on triglycerides in subjects without diabetes mellitus who have very high triglycerides over a period of 84 days;   The effects of DCCR on Apo B and non-HDL in subjects without diabetes mellitus who have very high triglycerides over a period of 84 days
7 Recruiting Study to Determine if Enhancing Glutamate Transporter Function Produces Antidepressant Effects in People With Major Depressive Disorder
Condition: Depression
Intervention: Drug: Diazoxide
Outcome Measures: MADRS total score;   Proportion of subjects achieving remission (MADRS less than/equal to 10) & amp; response (MADRS more than/equal to 50%) change from baseline in Beck Depression Inventory, Hamilton Anxiety Rating Scale, & amp; Hamilton Depression Rating...
8 Unknown  Central Mechanisms That Regulate Glucose Metabolism in Humans
Condition: Type 2 Diabetes
Intervention: Drug: Diazoxide
Outcome Measure:
9 Recruiting Mechanisms of Increased Androgen Production Among Women With Polycystic Ovary Syndrome
Condition: Polycystic Ovary Syndrome
Interventions: Radiation: 3-D Ultrasound;   Drug: recombinant human chorionic gonadotropin;   Drug: Recombinant follicle stimulating hormone;   Drug: Dexamethasone;   Drug: Adrenocorticotropin;   Drug: Glucose
Outcome Measures: 17-hydroxyprogesterone responses to hCG with and without FSH in PCOS women and normal controls;   Follicle count on 3-D Ultrasound in PCOS women and normal controls;   Adrenal androgen response to ACTH in PCOS women and normal controls;   17-hydroxyprogesterone response to hCG in the setting of reduced insulin secretion in PCOS women

These studies may lead to new treatments and are adding insight into Diazoxide etiology and treatment.

A major focus of Diazoxide research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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