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Digestin Medical Research Studies

Up-to-date List of Digestin Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Digestin Medical Research Studies

Rank Status Study
1 Recruiting Diet Intervention and GEnetic STudy (DIGEST-Pilot)
Conditions: Cardiovascular Diseases;   Inflammation;   Dyslipidemias;   Blood Pressure;   Hyperglycemia
Interventions: Other: Prudent Diet;   Other: Typical Western Diet
Outcome Measures: gene expression measuring ANRIL production;   epigenetic marks;   high-sensitivity C-reactive protein;   interferon-alpha-21;   interferon-gamma;   interleukin-1-alpha;   total cholesterol;   low-density lipoprotein-cholesterol;   high-density lipoprotein-cholesterol;   apolipoprotein-B;   fasting glucose;   systolic blood pressure;   diastolic blood pressure;   interleukin-6
2 Recruiting Role of Slowly Digesible Starch on Diabetes Risk Factors(STARCH)
Condition: Prediabetes
Interventions: Dietary Supplement: Amylose;   Dietary Supplement: Amylopectin
Outcome Measures: Insulin Sensitivity and Secretion;   Body Composition;   Gut Microbiota;   Satiety;   Hunger
3 Recruiting Effects of Resistant Starch in a Baked Snack Bar on a Post-prandial Glycemic and Insulinemic Response
Condition: Hyperglycemia, Diabetes, and Obesity
Intervention: Dietary Supplement: Resistant starch
Outcome Measure: resistant starch effects
4 Not yet recruiting Digestibility of Selected Resistant Starches in Humans
Conditions: Malabsorption; Carbohydrate;   Ileostomy - Stoma
Interventions: Other: Starch-free breakfast;   Other: Hi-Maize 260;   Other: Hylon VII;   Other: Amioca
Outcome Measures: Amount of carbohydrate in ileostomy effluent;   Amount of fiber in ileostomy effluent;   Amount of starch in ileostomy effluent
5 Recruiting The Effect of Prebiotics on the Microbiome in Irritable Bowel Syndrome Patients: The Diet and Microbiome Study
Condition: Irritable Bowel Syndrome
Intervention: Dietary Supplement: Factor Altered Diet
Outcome Measures: Area under the Curve of Hydrogen Gas on Lactulose Breath Test;   Change in Area Under the Curve on Lactulose Breath Test from Baseline;   Change in IBS Symptom Severity Score from Baseline
6 Recruiting Cigarette Smoking and Oral Microbiota
Conditions: Microbiota;   Lung Cancer;   Oral Cancer
Intervention:
Outcome Measure: This pilot study will provide essential information about collection, design and analyses that will enable further studies of the relationships between cigarette smoking, the oral microbiome and tobacco-related cancers.
7 Recruiting Effects of an Antioxidant-Enriched Multivitamin Supplement on Inflammation and Oxidative Stress in Cystic Fibrosis
Condition: Cystic Fibrosis
Interventions: Drug: AquADEKs-2;   Dietary Supplement: control multivitamin
Outcome Measures: Change in Sputum Myeloperoxidase (MPO) Level;   Number of Adverse Events;   Change in Systemic Antioxidant Levels;   Change in Systemic Markers of Inflammation and Oxidative Stress;   Change in Sputum Markers of Inflammation and Oxidative Stress;   Change in Systemic Vitamin Levels;   Changes in Lung Function Endpoints;   Change in Growth Endpoints;   Time to Pulmonary Exacerbation;   Number of Pulmonary Exacerbations;   Number of hospitalizations
8 Unknown  Probiotics in Infants With Gastroschisis
Condition: Gastroschisis
Interventions: Dietary Supplement: Bifidobacteria infantis;   Other: Placebo
Outcome Measures: Composition of the fecal microbiota;   Length of hospital stay
9 Recruiting Is Our Microbiome a Predictor of Cardiac Risk
Condition: Coronary Artery Disease
Intervention:
Outcome Measures: 50 cc blood obtained during angiogram and used for Endothelial Progenitor Cells analysis using antibodies for inflammatory markers. Plasma collection will be done for antibody analysis. Buffy coats will be frozen and stored for future genetic analysis.;   Stool samples will be collected to compare the fecal microbiota of patients with mild, moderate and severe coronary artery disease.
10 Unknown  Dose Response of Intravenous Sincalide(CCK-8) for Gallbladder Emptying
Condition: Healthy
Interventions: Drug: CCK-8 0.02mg/kg;   Drug: CCK-8 0.02 mg/kg
Outcome Measure: Normal gallbladder ejection fraction
11 Recruiting A Study to Evaluate the Effects of a Natural Supplement in Adults With Chronic Functional Constipation
Condition: Constipation
Intervention: Dietary Supplement: Natural Fibre Supplement
Outcome Measures: Number of bowel movements per week;   Stool consistency, as measured by the Bristol Stool Form Scale;   Quality of life as measured by the Quality of Life Questionnaire (PAC-QOL);   Constipation symptoms as measured by PAC-SYM;   Laxative use by subjects with functional constipation
12 Recruiting Stroke in Young Fabry Patients (sifap2): Characterization of the Stroke Rehabilitation
Conditions: Fabry Disease;   Cerebrovascular Accident
Intervention: Other: No intervention
Outcome Measures: Determination of the relapse rate of acute cerebrovascular events with clinical relevance in patients with different prophylactic approaches;   Number of acute CVEs without clinical significance but with obvious signs in MRI diagnosis;   Quality of Life measured with the SF-36;   Beck Depression Inventory II (BDI II);   Brief Pain Inventory (BPI);   Rostocker Kopfschmerzfragen-Komplex (RoKoKo) (only in Austria and Germany);   Habi test (only in Austrian and German centers);   Trail Making Test (TMT);   Functional neurological deficits measured by the Mini Mental State Examination (MMSE)
13 Unknown  The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population
Conditions: Lactose Intolerance;   Irritable Bowel Syndrome
Intervention: Dietary Supplement: dietary restriction
Outcome Measures: To assess the effects of lactose intolerance on gastrointestinal function and symptoms;   To measure the intake of dietary lactose in the adult general population and in patients with IBS;   To assess genetic factors, tolerance to lactose challenge and visceral sensitivity.;   To assess appropriate dosage of lactose hydrogen breath test;   To determine the impact of a determined dietary intervention on abdominal symptoms compatible with D-IBS.;   To explore the association of visceral sensitivity induced by LI with mucosal immune activation and psychological factors in D-IBS patients
14 Recruiting The Effects of Added Enzyme α-Galactosidase at a Carbohydrate-rich Meal in Irritable Bowel Syndrome (IBS)
Condition: Irritable Bowel Syndrome
Intervention: Dietary Supplement: Alpha-Galactosidase
Outcome Measures: Change in symptoms;   Changes in expiration air
15 Recruiting Antibody Treatment for Advanced Celiac Disease
Conditions: Celiac Disease;   Celiac Sprue;   Gluten Enteropathy;   Gluten-Sensitive Enteropathy
Intervention: Biological: Hu-Mik- Beta-1
Outcome Measure: safety of Hu MIK Beta 1 in celiac disease pts
16 Recruiting Investigation of Synbiotic Treatment in NAFLD
Condition: Non-Alcoholic Fatty Liver Disease
Interventions: Dietary Supplement: Synbiotic;   Dietary Supplement: Maltodextrin
Outcome Measures: Change in biomarkers for NAFLD and change in liver fat;   Change in adipose tissue inflammation, satiety and risk factors for type 2 diabetes.;   Change in adipose tissue inflammation, satiety and risk factors for type 2 diabetes
17 Not yet recruiting Speed of Increasing Milk Feeds Trial
Conditions: Premature Birth;   Nosocomial Infections;   Necrotizing Enterocolitis
Intervention: Dietary Supplement: Milk feed (breast milk or formula milk)
Outcome Measures: Survival without serious disability;   Incidence of microbiologically-confirmed or clinically strongly-suspected late-onset invasive infection;   Incidence of necrotizing enterocolitis;   Time to reaching full milk feeds (defined as 150 ml/kg/day);   Growth at discharge;   Total duration of parenteral feeding before discharge from hospital;   Number of days spent in intensive care;   Duration of hospital stay
18 Recruiting Early Supplementation of Enteral Microlipid With and Without Fish Oil in Premature Infants With Enterostomies
Conditions: Prematurity;   Intestine Perforation;   Necrotizing Enterocolitis (NEC);   Short Bowel Syndrome (SBS)
Interventions: Dietary Supplement: Microlipid and fish oil;   Dietary Supplement: Microlipid
Outcome Measures: The serum biomarkers of oxidative stress and inflammatory cytokines;   The average enteral calorie (% of total calorie) intake before reanast;   The average weight gain (g/day) after reanastomosis
19 Recruiting Fructose and Fructans in IBS
Condition: Irritable Bowel Syndrome
Interventions: Dietary Supplement: Glucose;   Dietary Supplement: Fructose;   Dietary Supplement: Fructans
Outcome Measures: Symptom response (yes/no);   Symptom Intensity;   Breath Hydrogen;   Colonic Gas Volume;   Small Bowel Water Content
20 Not yet recruiting The Effect of Probiotics on Lactose Intolerance
Condition: Lactose Intolerance
Intervention: Dietary Supplement: Bio-25
Outcome Measure: Change of hydrogen levels measured due to probiotics administration

These studies may lead to new treatments and are adding insight into Digestin etiology and treatment.

A major focus of Digestin research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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