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Distress Medical Research Studies

Up-to-date List of Distress Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Distress Medical Research Studies

Rank Status Study
1 Recruiting Echocardiography Predictive of the Inefficacy and/or of the Unsafeness of Recruitment Maneuvers in Patients With Acute Respiratory DISTRESS Syndrome.
Condition: Acute Respiratory DISTRESS Syndrome
Intervention: Device: Echocardiography
Outcome Measures: Efficacy and safety of recruitment maneuvers in patients with Acute Respiratory DISTRESS Syndrome.;   Feasibility of the measurement of Longitudinal Strain and Strain Rate of the right ventricle in patients suffering from Acute Respiratory DISTRESS Syndrome.;   Comparison of the results of echocardiographic measurements between the group CONTROL and the group FAILURE.;   Evaluate the effect of the inefficacy and/or of the unsafeness of the recruitment maneuver on the future of the patient suffering from Acute Respiratory DISTRESS Syndrome.
2 Not yet recruiting Curosurf/Budesonide for Infants With Respiratory DISTRESS Syndrome
Condition: Respiratory DISTRESS Syndrome
Intervention: Drug: Budesonide
Outcome Measures: need of pulmonary surfactant;   the incidence of bronchopulmonary dysplasia
3 Recruiting Urine NT-ProBNP in Neonatal Respiratory DISTRESS
Condition: Neonatal Respiratory DISTRESS
Outcome Measure: severity of respiratory DISTRESS
4 Recruiting Lung Ultrasound to Diagnose Transient Tachypnea of the Newborn (TTN) Versus Respiratory DISTRESS Syndrome (RDS) in Neonates
Conditions: Transient Tachypnea of the Newborn;   TTN;   Respiratory DISTRESS Syndrome;   RDS
Interventions: Other: Respiratory DISTRESS Group;   Other: Control Group
Outcome Measure: lung ultrasound
5 Recruiting DISTRESS Tolerance Treatment for Substance Users
Condition: Substance Dependence
Intervention: Behavioral: Skills for Improving DISTRESS Intolerance
Outcome Measures: abstinence at 1, 3, 6 & 12 month follow-up;   DISTRESS tolerance
6 Unknown  Intratracheal Vitamin A Administration With Surfactant for Newborn Respiratory DISTRESS Syndrome
Conditions: RDS;   Infant, Newborn;   Vitamin A;   Surfactant
Interventions: Drug: surfactant;   Drug: surfactant+vitamin A
Outcome Measures: Intratracheal Vitamin A Administration with Surfactant for Newborn Respiratory DISTRESS Syndrome;   Overall clinical outcomes at Newborn Infants With Respiratory DISTRESS Syndrome
7 Recruiting Caregiver Burden and DISTRESS in Hematopoeitic Stem Cell Transplant
Conditions: Depression;   Anxiety;   Fatigue;   DISTRESS
Outcome Measures: Level of DISTRESS & Feelings of Burden;   Impact of patient DISTRESS, fatigue & pain on the level of caregiver DISTRESS & burden;   Impact of caregiver DISTRESS and burden on overall patient survival and length of patient hospitalization;   Common characteristics of caregivers
8 Recruiting Measuring DISTRESS Tolerance With Functional MRI
Condition: Cocaine Dependence
Outcome Measures: To identify neural indices of DISTRESS tolerance using fMRI in healthy non-drug users, and examine the relationship between these neural indices and important physiological, biological, and behavioral correlates of DISTRESS tolerance.;   To determine if neural processes associated with DISTRESS tolerance predict sustained abstinence among treatment seeking cocaine dependent participants following 1, 3, 6, and 12 months follow-up.
9 Not yet recruiting Effects of Positive End-expiratory Pressure and Tidal Volume on Fluid Responsiveness of Acute Respiratory DISTRESS Syndrome
Condition: Respiratory DISTRESS Syndrome, Adult
Intervention: Other: Infusion of 6% tetrastarch for a total of 500 ml
Outcome Measure: increase of cardiac output after volume expansion
10 Not yet recruiting Tolerance of nHFPV Versus nCPAP in Neonatal Respiratory DISTRESS
Condition: Neonatal Respiratory DISTRESS
Interventions: Device: Nasal continuous airway positive pressure (nCPAP);   Device: Nasal high frequency percussive ventilation (nHFPV)
Outcome Measures: Measurement of cerebral tissue oxygenation (rSO2c) by near infrared spectroscopy (NIRS). We compared the mean of the variation of rSO2c during the last 5 minutes for each device (nHFPV and nCPAP).;   Measurement of transcutaneous capnia and oxygen saturation; variation of heart rate, breath rate and blood pressure; evolution of the Silvermann score; ventilators' setting (PEEP, FiO2).
11 Recruiting Perfluorocarbon (PFC) Inhalation Treatment of Acute Lung Injury/Acute Respiratory DISTRESS Syndrome
Conditions: Respiratory DISTRESS Syndrome, Adult;   Acute Lung Injury
Interventions: Drug: Perfluorocarbon;   Drug: Sterile Water for Injection
Outcome Measures: oxygenation index, respiratory mechanics;   Survival
12 Recruiting Mindfulness: a Novel Approach for the Management of Diabetes-related DISTRESS
Conditions: Emotional DISTRESS;   Type 2 Diabetes;   Stress
Intervention: Behavioral: Mindfulness Based Stress Reduction
Outcome Measures: HgA1c;   Diabetes DISTRESS;   SF36 Physical Health Score;   SF36 Mental Health Score;   Mean 24 hour ambulatory systolic blood pressure;   Mean 24 hour diastolic ambulatory blood pressure;   HOMA-IR;   Depression;   State Anxiety;   Trait Anxiety;   Social Support;   Coping Style;   General Stress;   Cortisol 24 hour area under the curve;   Cortisol Awakening Response;   IL-6;   Summary of Diabetes Self-Care Activities;   Average 24 hour glucose by continuous glucose monitor (cgm);   Average night time glucose;   Average day time glucose;   Block Food Frequency Questionnaire;   Mean Day Systolic Ambulatory Blood Pressure;   Mean Day Diastolic Ambulatory Blood Pressure;   Mean Night Systolic Ambulatory Blood Pressure;   Mean Night Diastolic Ambulatory Blood Pressure
13 Unknown  Surfactant Versus Nasal Continuous Positive Airway Pressure (nCPAP) for Respiratory DISTRESS Syndrome in the Newborn ≥ 35 Weeks of Gestation
Condition: Acute Respiratory DISTRESS Syndrome
Interventions: Procedure: Surfactant instillation;   Procedure: nCPAP
Outcome Measures: Succes of the procedure;   Morbidity associated to the management of a newborn with RDS in a neonatal intensive care unit
14 Unknown  Hypertonic Saline for Outpatient Bronchiolitis
Conditions: Bronchiolitis;   Respiratory DISTRESS
Interventions: Drug: Inhalation of salbutamol diluted in hypertonic saline;   Drug: Inhalation of salbutamol diluted in normal saline
Outcome Measures: Change in the respiratory DISTRESS score (Tal) between the basal score and the final score after 3 salbutamol nebulizations;   Change in the respiratory DISTRESS score (Tal) between the basal score and the first nebulization;   Change in the respiratory DISTRESS score (Tal) between the basal score and the second nebulization;   Change in pulse oxymetry reading between the basal score and after each of the three nebulizations;   Change in cardiac frequency, irritability, general condition or anything else between the basal score and the first, second and third nebulization
15 Unknown  Psychological and Physical DISTRESS and Care Needs in Operable Lung Cancer Patients Receiving Surgery
Conditions: Anxiety Postoperative;   Patient Non-Compliance;   Psychological DISTRESS
Outcome Measure:
16 Recruiting Long Term (1 Year) Respiratory Sequelae in Children Surviving an Acute Respiratory DISTRESS Syndrome
Condition: Acute Respiratory DISTRESS Syndrome
Outcome Measure:
17 Recruiting Early Spontaneous Breathing in Acute Respiratory DISTRESS Syndrome
Condition: Acute Respiratory DISTRESS Syndrome
Interventions: Procedure: APRV;   Biological: arterial blood gas measurement each morning
Outcome Measures: all cause hospital mortality;   all causes mortality;   number of days alive without mechanical ventilation;   number of days alive without organ failure;   number of patients with refractory hypoxemia;   number of patients requiring adjuvant treatment of hypoxemia;   number of days alive without sedation;   total amount of sedative drugs;   amount of sedative drugs received daily living;   number of days alive without vasoactive drugs;   total amount of vasoactive drugs;   amount of vasoactive drugs received daily living;   Number of patients with a pneumothorax;   Duration of mechanical ventilation;   Duration of stay in ICU;   Changes in serum levels of proinflammatory cytokines
18 Recruiting Extracorporeal Membrane Oxygenation for Severe Acute Respiratory DISTRESS Syndrome
Condition: Acute Respiratory DISTRESS Syndrome (ARDS)
Interventions: Device: ECMO (Quadrox®, Jostra®, Maquet®);   Other: conventional care
Outcome Measures: All cause mortality on day 60 following randomization;   mortality on day 30 in-ICU or in-hospital mortality;   mortality on day 90 in-ICU or in-hospital mortality
19 Recruiting Human Mesenchymal Stem Cells For Acute Respiratory DISTRESS Syndrome
Condition: Acute Respiratory DISTRESS Syndrome
Intervention: Biological: Allogeneic Bone Marrow-Derived Human Mesenchymal Stem Cells
Outcome Measure: Comparison of treatment adverse event rates between the 1, 5 and 10 million cells per kilogram dose cohorts
20 Unknown  Comparison of 2 Strategies of Adjustment of Mechanical Ventilation in Patients With Acute Respiratory DISTRESS Syndrome
Conditions: Acute Respiratory DISTRESS Syndrome;   Acute Lung Injury
Intervention: Device: Setting of positive end-expiratory pressure
Outcome Measures: Mortality at 28 days;   Mortality at 60 days;   In hospital mortality;   Ventilator free Days through day 28;   Number of new organ failure before day 28;   Proportion of patients alive and unassisted breathing at 28 days;   Number of patients with pneumothorax;   Number of days alive between the first positive "potential weanability test" and day 28

These studies may lead to new treatments and are adding insight into Distress etiology and treatment.

A major focus of Distress research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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