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Disturbance Medical Research Studies

Up-to-date List of Disturbance Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Disturbance Medical Research Studies

Rank Status Study
1 Recruiting Students, Parents, and Teachers On Track: Intervention Development for Youth With Emotional Disturbance
Condition: Emotional Disturbance
Intervention: Behavioral: On Track
Outcome Measure: Successful School Transition
2 Recruiting Measuring Sleep Disturbance Among Cancer Patients
Condition: Advanced Cancer
Interventions: Behavioral: Questionnaire;   Device: Actigraph
Outcome Measure: Sensitivity of Brief Sleep Disturbance Scale (BSDS)
3 Recruiting Acupuncture for Sleep Disturbances in OEF/OIF Veterans With Post Traumatic Stress Disorder
Conditions: Post Traumatic Stress Disorder;   Sleep Disturbance
Intervention: Device: Auricular Acupuncture
Outcome Measures: Change in Objective Sleep Times;   Change in Subjective Sleep Times;   Acceptability of Acupuncture as a Treatment for Sleep Disturbance;   Change in Sleep Quality;   Change in Depression;   Change in Post Traumatic Stress Disorder Symptoms
4 Recruiting MsFLASH-04: Pilot Trial: Telephone Behavioral Therapy for Menopause-related Sleep Disturbance
Conditions: Hot Flashes;   Menopause;   Vasomotor Disturbance;   Sleep
Intervention: Behavioral: Cognitive Behavioral Therapy-Insomnia (CBT-I)
Outcome Measures: Insomnia Symptoms;   Sleep Quality
5 Unknown  Cognitive-Behavioral Therapy for Sleep Disturbance in Patients Undergoing Hemodialysis
Conditions: Insomnia;   Depression;   Inflammation
Intervention: Behavioral: cognitive behavioral therapy
Outcome Measures: improvement of sleep Disturbance/depression/anxiety;   Changes of inflammatory cytokines/oxidative stress
6 Unknown  Sleep Disturbance in Deployed Soldiers
Condition: Sleep Disturbance
Intervention: Other: Relaxation CD
Outcome Measures: Actigraph and self report questionnaires;   Self report questionnaires
7 Recruiting The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia
Conditions: Sleep Disorders;   Fibromyalgia;   Sleep
Intervention: Drug: Milnacipran
Outcome Measures: Overnight polysomnography to measure sleep Disturbance;   Subjective measures with change in sleep and change in pain measures
8 Unknown  Pedunculo-Pontin Nucleus (PPN) - Deep Brain Stimulation (DBS) in Gait and Balance Disturbance in Parkinson's Disease (PPN-GAB-PARK Study)
Condition: Parkinson Disease
Intervention: Device: Deep brain stimulation electrode
Outcome Measures: Primary endpoint will be the optimal parameters of PPN-DBS, defined as those leading to the best improvement of posture, balance and gait Disturbance;   Efficacy of PPN-DBS on Disturbance of posture, balance and gait;   Long term tolerance will be assessed by general and neurological examination, neuro-psychological tests (MMS, Mattis-DRS, Score fontal, BREF, MADRS) and by assessment of adverse events;;   the components of gait that are most improved by PPN-DBS will be determined using computer-based systems (GAITRite and VICON);;   evaluation of unilateral versus bilateral stimulation will be done during the double-blind assessment of all efficacy criteria;;   effects of PPN-DBS on other PD symptom will be assessed using UPDRS and Hoehn and Yahr's staging;;   the impact of PPN-DBS on quality of life and activities of daily living will be assessed by UPDRS II, SF36 and PDQ39 questionnaires and by a global satisfaction scale.
9 Unknown  Effects of Rasagiline on Sleep Disturbances in Parkinson's Disease
Conditions: Sleep Disturbances;   Parkinsons's Disease
Interventions: Drug: Rasagiline;   Drug: Placebo
Outcome Measures: Change in sleep efficacy;   Change in PDSS-2;   Change in other sleep parameters;   Electrocardiography;   Laboratory parameter
10 Recruiting Biobehavioral Pain Management in TMD
Condition: Temporomandibular Joint Disorder
Interventions: Behavioral: Cognitive Therapy for Catastrophizing;   Behavioral: Behavioral Therapy for Sleep Continuity Disturbance
Outcome Measures: To investigate a proposed causal chain for TMJD pain based on changes in pain modulation, inflammatory profile and clinical pain.;   Impact of pre-sleep cognitive arousal on autonomic and cortical arousal during sleep;   Determine if manipulation of TMJD pain risk factors (SCD and CAT) reduces autonomic/cortical arousal.;   Determine if BT-SCD and CT-CAT treatments alter clinical pain and inflammatory activity relative to control.
11 Unknown  Treatment of Sleep Disturbances in Young Children With Autism
Conditions: Autism;   Autism Spectrum Disorders
Intervention: Behavioral: ParentTraining
Outcome Measures: Modified Simond & Parraga Sleep Questionnaire (MSPSQ);   Actigraphy
12 Recruiting Study of Brexpiprazole as Adjunctive Treatment of Sleep Disturbances in Patients With Major Depressive Disorder
Condition: Sleep Disturbances
Intervention: Drug: Brexpiprazole
Outcome Measures: Change from baseline to Week 8 in polysomnographic recording (PSG) parameters;   Change from baseline to Week 8 in actigraphy parameters;   Change from baseline to Week 8 in subjective parameters using sleep diary;   Change from baseline to Week 8 on ISI total score;   Change from baseline to Week 8 on ESS total score;   Change from baseline to Week 8 on 10-min PVT mean reaction time (RT) and on the number of lapses;   Change from baseline to Week 8 on BRIAN total score;   Change from baseline to Week 8 on CPFQ total score;   Change from baseline to Week 8 on time of peak cortisol concentration and timing of DLMO;   Change from baseline to Week 8 on BL-VAS-s following awakening;   Change from baseline to Week 8 in MADRS total score;   Change from baseline to Week 8 in CGI-S score;   CGI-I score at Week 8;   Proportion of Responders at Week 8 (response defined as a ≥50% decrease in MADRS total score from baseline);   Safety;   Tolerability;   Risk of suicidality
13 Recruiting Delta-THC in Dementia
Conditions: Behavioural Disturbances;   Pain;   Dementia;   Alzheimer's Dementia;   Vascular Dementia
Interventions: Drug: delta-9-tetrahydrocannabinol (delta-THC);   Drug: Placebo;   Drug: Acetaminophen
Outcome Measures: Neuropsychiatric Inventory (NPI);   Pain Assessment Checklist for Seniors with Limited Ability to Communicate Dutch version (PACSLAC-D);   Caregiver Clinical Global Impression of Change (CCGIC);   Cohen-Mansfield Agitation Inventory (CMAI);   Quality of Life-Alzheimer's Disease Scale (QoL-AD);   Barthel Index;   Paired Associates Learning test Wechsler Memory Scale Revised(PAL WMS-R);   Safety assessments;   Verbal Rating Scale (VRS)
14 Recruiting Body Image and Self-Care in HIV-Infected MSM
Conditions: Body Image Disturbance;   Medication Adherence
Interventions: Behavioral: Experimental Intervention;   Behavioral: TAU
Outcome Measures: Change in Body Image Disturbance;   Change in HIV Self-Care Behavior and Depression
15 Unknown  Effects of Cognitive-Behavioral Therapy on Sleep Disturbance in Peritoneal Dialysis Patients
Conditions: Sleep Disorders;   Kidney Diseases
Intervention: Behavioral: cognitive-behavioral therapy
Outcome Measures: Check Pittsburgh Sleep Quality Index and restless leg syndrome index: in 1st and 3rd months;   The hematologic, biochemical markers, and peritoneal function in 1st and 3rd months
16 Recruiting Effect of Moderate to High Intensity Aerobic Interval Training on Polysomnographic Measured Sleep in Patients With Rheumatoid Arthritis
Conditions: Rheumatoid Arthritis;   Sleep Disturbances
Intervention: Behavioral: High intensity aerobic interval training
Outcome Measures: sleep;   Cardiopulmonary fitness;   Plasma;   physiological outcomes;   Disease activity;   self reported sleep quality and sleep Disturbances;   self reported sleepiness;   self reported fatigue;   self reported depressive symptoms;   Physical function;   self reported Health-related quality of life;   Health and lifestyle questionnaire;   Sleep pattern
17 Unknown  Mechanisms of Sleep Disturbance in Children With Generalized Anxiety Disorder (GAD)
Conditions: Generalized Anxiety Disorder;   Sleep Disturbances
Outcome Measure:
18 Recruiting Pharmacogenomics Study of Sleep Disturbance and Neurocognitive Impairments in the Opioid Addicts
Condition: Heroin Dependence
Outcome Measure:
19 Recruiting Taste Disorders in Middle Ear Disease and After Middle Ear Surgery
Condition: Taste Disturbance
Interventions: Other: taste measurement;   Other: Symptom questionnaire;   Behavioral: Quality of life questionnaire;   Other: Nerve sample
Outcome Measures: Taste Disturbance;   Quality of life;   Histopathological changes
20 Recruiting Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at High Altitude
Condition: High-altitude Sleep Disturbance
Interventions: Drug: Temazepam;   Drug: Acetazolamide
Outcome Measures: Global assessment of sleep quality using a 100mm visual analog scale;   The Groningen Sleep Quality Questionnaire survey;   Sleep Onset Latency;   Total Sleep Duration;   Time in Bed;   Number of Awakenings;   Number of Awakenings to Urinate;   Wake Time After Sleep Onset;   Terminal Wakefulness;   Global assessment of sleep depth;   Global assessment of drowsiness;   Stanford Sleepiness Scale scores;   Lake Louis Acute Mountain Sickness delta score;   Mean O2 Saturation;   Proportion of time in periodic breathing;   Number of desaturation events per hour;   Number of awakenings per hour;   Sleep Efficiency

These studies may lead to new treatments and are adding insight into Disturbance etiology and treatment.

A major focus of Disturbance research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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