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Diuretics Medical Research Studies

Up-to-date List of Diuretics Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Diuretics Medical Research Studies

Rank Status Study
1 Recruiting Protocolized Diuretic Strategy in Cardiorenal Failure
Conditions: Cardiac Failure;   Renal Failure;   Kidney Failure
Intervention: Drug: Protocolized Diuretic Strategy
Outcome Measures: Change in body weight (kg) from randomization to 96 hours;   Length of hospitalization;   Number of rehospitalizations for heart failure (HF);   All-cause mortality;   Venous compliance of the internal jugular vein;   Fluid balance;   Clinical decongestion;   Health-related quality of life (HRQOL);   Renal Outcomes;   Cardiovascular Mortality;   Urine output
2 Recruiting Assessment of Coronary Flow Reserve in Heart Failure Patients After Ultrafiltration Versus Diuretics
Condition: Acute Decompensated Heart Failure
Interventions: Drug: Loop Diuretics (furosemide, torsemide, bumetanide);   Other: Ultrafiltration
Outcome Measure: Myocardial Blood Flow
3 Recruiting Acetazolamide and Spironolactone to Increase Natriuresis in Congestive Heart Failure
Condition: Heart Failure
Interventions: Drug: Combination therapy with acetazolamide and low-dose loop Diuretics;   Drug: High-dose loop Diuretics;   Drug: Upfront therapy with oral spironolactone
Outcome Measures: Acetazolamide arm: natriuresis 24 h;   Spironolactone arm: incidence of hypo- (serum potassium <3.5 mmol/L) or hyperkalemia (serum potassium >5.0 mmol/L);   NT-proBNP change after 72 h;   Worsening renal function;   Persistent renal impairment;   Peak plasma aldosterone concentration after 72 h;   Peak plasma renin activity after 72 h
4 Not yet recruiting Safety and Efficacy of the Combination of Loop With Thiazide-type Diuretics in Patients With Decompensated Heart Failure
Condition: Heart Failure
Interventions: Drug: hydrochlorothiazide;   Drug: Placebo
Outcome Measures: Changes in body weight;   Diuresis;   Patient-reported dyspnea;   Worsening renal function;   Changes in electrolyte levels (sodium and potassium)
5 Unknown  Loop Diuretics Administration and Acute Heart Failure
Condition: Acute Heart Failure
Intervention: Drug: furosemide infusion
Outcome Measures: evaluation of renal function and BNP levels during loop diuretic infusion;   length of hospitalization and evaluation of cardiac events in the two groups
6 Recruiting Effectiveness of a Diuretic Algorithm in Clinical Stability in Heart Failure Patients
Condition: Heart Failure
Interventions: Drug: Furosemide and Phone contact;   Drug: Furosemide
Outcome Measures: Emergency room visits for Heart Failure;   Readmissions for Heart Failure
7 Recruiting Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function
Conditions: Chronic Kidney Insufficiency;   Hemodialysis Treatment;   Diuresis Preserved
Intervention: Drug: Hydrochlorothiazide and furosemide
Outcome Measures: To asses the effect of combined hydrochlorothiazide-furosemide therapy on weight gain between haemodialysis sessions in patients with RRF;   To asses the effect of combined hydrochlorothiazide-furosemide therapy on dialytic, clinical and analytical variables and use of the antihypertensive treatment
8 Recruiting ELEVATE Early LEvosimendan Vs Usual Care in Advanced Chronic hearT failurE
Condition: Advanced Chronic Heart Failure
Interventions: Drug: Diuretics;   Drug: Levosimendan
Outcome Measures: Number of days alive free of Transplant and out-of-hospital (DAOH);   Incidence of acute renal dysfunction;   All cause mortality, hospital readmission and unscheduled office and emergency department visits for ADCHF;   BNP changes;   Number of hospital admissions for acute worsening HF;   Costs;   Treatment-related adverse events;   Adverse changes in blood pressure or heart rate;   ECG changes
9 Recruiting The Effect of Loop Diuretics on Severity and Outcome of Acute Kidney Injury
Condition: Acute Kidney Failure
Intervention: Drug: Furosemide
Outcome Measure: Non-renal recovery
10 Recruiting Causal Inference Research of Resistant Hypertension Treatment With Chinese Approach in a Cohort Study
Conditions: Primary Hypertension;   Hypertension, Resistant to Conventional Therapy
Interventions: Drug: Herbs;   Drug: Thiazide Diuretics and ACE inhibitor and β-blocker
Outcome Measures: Systolic (SBP) and diastolic (DBP) blood pressure reductions;   Cardiac event;   Death incident;   scores for symptoms and signs
11 Unknown  Double Blind Crossover Comparison of Diuretics in the Young
Condition: Low-Renin Hypertension
Interventions: Drug: Bendroflumethiazide 2.5mg - 5mg;   Drug: Amiloride 20-40mg;   Drug: Spironolactone 50-100mg;   Drug: Frusemide 20-40mg;   Drug: Bendroflumethiazide 1.25-2.5mg/ Amiloride 10-20mg combined
Outcome Measures: Difference in systolic blood pressure for subjects' best drug and second best drug.;   Difference in plasma renin for subjects' best drug and second best drug.;   Predictions of best drug
12 Recruiting Sodium-Restricted Diet and Diuretic in the Treatment of Severe Sleep Apnea
Condition: Obstructive Sleep Apnea
Interventions: Drug: Lasilactone;   Other: Sodium-Restricted Diet
Outcome Measures: Apnea-Hypopnea Index;   Somnolence scale (Epworth) and ventilatory parameters;   Lipid profile;   Aldosterone-Renin and sodium and potassium balance;   Renal Function;   C reactive protein
13 Unknown  Human Albumin for the Treatment of Ascites in Patients With Hepatic Cirrhosis
Conditions: Liver Cirrhosis;   Ascites
Interventions: Drug: Diuretics plus human albumin;   Drug: Diuretics (standard medical treatment)
Outcome Measures: Mortality;   Incidence of cirrhosis-related clinical complications;   Number of total paracentesis;   Number of patients potentially needing TIPS (3 paracentesis/month);   Quality of life;   Analysis of the cost/effectiveness ratio;   Incidence of refractory ascites according to the IAC criteria
14 Recruiting Oral Metolazone and Intermittent Intravenous Furosemide Versus Continuous Infusion Furosemide in Acute Heart Failure
Condition: Acute Decompensated Heart Failure
Interventions: Drug: Intravenous Bolus Furosemide and Oral Metolazone;   Drug: Intravenous Continuous Infusion Furosemide
Outcome Measures: Daily net fluid output;   Patient Global Assessment Scale;   Daily urine output (mL urine out per mg furosemide received);   Need for additional or alternative diuretic (crossover) or IV vasoactive therapy (study failure);   Death, rehospitalization, and unscheduled visit for HF to an emergency department or outpatient clinic;   Critically low potassium (< 3.5 mmol/L) and magnesium (< 1.6 mg/dL) concentrations;   Change in blood urea nitrogen or creatinine;   Number of hypotensive episodes defined as systolic blood pressure below 85 mmHg or greater than 10 mmHg below baseline (whichever is greater);   Total number of times antihypertensive doses are held due to low blood pressure
15 Not yet recruiting The Impact of TORasemide oN hemodynAmic and Neurohormonal Stress, and carDiac remOdeling in Heart Failure
Condition: Heart Failure
Interventions: Drug: Furosemide;   Drug: Torasemide
Outcome Measures: The influence of therapy on cardiovascular events associated with heart failure (deaths, hospitalisations);   The change of dosing of diuretic due to worsening of condition of patient.;   The change of NYHA (New York Heart Association) class - worsening or improvement
16 Unknown  Comparing the Effects of Conivaptan and Diuretics on Plasma Neurohormones and Renal Blood Flow in Patients With Chronic Congestive Heart Failure
Condition: Heart Failure
Interventions: Drug: Conivaptan;   Drug: Furosemide;   Drug: Conivaptan and furosemide
Outcome Measures: renal hemodynamics renal blood flow and glomerular filtration rate;   measure plasma neurohormone levels
17 Recruiting Effects of Angiotensin II Receptor Blocker Compared With Diuretics in High-risk Hypertensive Patients
Condition: Essential Hypertension
Intervention: Drug: Amlodipine, Telmisartan, Amiloride Compound , Simvastatin
Outcome Measures: The primary study outcomes are composite of non-fatal stroke, non-fatal myocardial infarction and cardiovascular death.;   All cardiovascular events;all-cause death, hospitalization for angina pectoris, coronary revascularization, aortic dissection, cerebrovascular disease, heart failure, renal insufficiency, tumor, new onset of atrial fibrillation and diabetes mellitus
18 Recruiting Handheld Ultrasound Evaluation of the Inferior Vena Cava to Guide Heart Failure Treatment
Condition: Heart Failure
Interventions: Device: Handheld ultrasound;   Device: Sham ultrasound
Outcome Measures: Days out of hospital for cardiovascular reasons;   Change in New York Heart Association Class;   Change in Health related quality of life;   Length of stay
19 Recruiting Diuretics and Dopamine in Heart Failure With Preserved Ejection Fraction
Condition: Heart Failure, Diastolic
Interventions: Drug: Furosemide;   Drug: Dopamine
Outcome Measures: Change in glomerular filtration rate at 72 hours;   Change in incidence of acute kidney injury;   Volume of diuresis measured in liters;   Six minute walk distance;   Global well-being assessment score;   Heart failure readmissions;   Frailty index;   Subjective dyspnea score;   Length of stay
20 Recruiting Tolvaptan/Ultrafiltration in the Treatment of Acute Heart Failure
Condition: Acute Decompensated Heart Failure
Interventions: Drug: loop diuretic;   Drug: tolvaptan;   Procedure: ultrafiltration
Outcome Measures: Net change in weight;   net volume loss;   urinary NGAL;   dyspnea score;   BNP change from admission to discharge;   serum creatinine change;   serum sodium and potassium changes;   Quality of Life;   all cause readmission;   all cause death

These studies may lead to new treatments and are adding insight into Diuretics etiology and treatment.

A major focus of Diuretics research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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