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Dobutamine Medical Research Studies

Up-to-date List of Dobutamine Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Dobutamine Medical Research Studies

Rank Status Study
1 Not yet recruiting Outcome and Safety of Intermittent Dobutamine Infusion at a Day-Care Center in Advanced Heart Failure Patients
Condition: Heart Failure
Interventions: Drug: Dobutamine;   Drug: Normal Saline
Outcome Measures: • Improvement in maximal oxygen consumption (VO2 max);   • Combined endpoint of heart failure or all-cause mortality at 6 and 12 months of follow-up
2 Unknown  Effects of Dobutamine on Microcirculation, Regional and Peripheral Perfusion in Septic Shock Patients
Condition: Septic Shock
Interventions: Drug: Dobutamine;   Drug: Placebo
Outcome Measures: Change in the perfused vascular density;   Macrohemodynamics;   Transthoracic echocardiography;   Gastric mucosal perfusion;   Hepatosplanchnic blood flow;   Peripheral perfusion;   Metabolic perfusion assessment
3 Recruiting Dopamine Versus Dobutamine for Treatment of Arterial Hypotension in Term and Preterm Neonates
Condition: Arterial Hypotension
Interventions: Drug: Dobutamine;   Drug: Dopamine
Outcome Measures: Cerebral tissue oxygen saturation;   Cardiac output
4 Unknown  Dobutamine Versus Placebo for Low Superior Vena Cava Flow in Newborns
Condition: Hemodynamic Instability
Interventions: Drug: Dobutamine;   Drug: Placebo
Outcome Measures: Low SVCF prevalence;   Required dose for achieving SVCF-OP (≥40 cc/kg/min);   Required dose for achieving SVCF-OP-60 (≥40 cc/kg/min maintained during 60 minutes);   NIRS variables;   Doppler-cranial ultrasonography (PD-CUS) variables.;   Invasive or non-invasive arterial blood pressure;   Central and peripheral temperature;   Heart rate;   Respiratory rate;   Other echocardiographic variables;   Biochemistry markers;   Structural brain damage markers:;   Mortality and neurodevelopment variables
5 Not yet recruiting NeoAdapt 3: Novel Biomarkers in the Evaluation of Neonatal Circulatory Insufficiency in Babies Suffering From Hypoxic Ischemic Encephalopathy
Condition: Circulatory Failure
Intervention: Drug: Dobutamine
Outcome Measures: Superior Vena Cava Flow (SVCF) in babys recieving total body cooling for Hypoxic Ischemic Encephalopathy;   Pleth Variability Index (PVI) in infants undergoing total body cooling treatment for hypoxic ischemic encephalopathy;   Pharmacokinetic data for the emilmination half life of Dobutamine when this drug is given for circulatory failure;   SVCF and PVI values corrleation to each other and to parameters that assess circulatory status such as mean blood pressure and capillary refill time;   SVCF and PVI values relationship to clinical outcomes;   SVCF and PVI values and Dobutamine treatment for circulatory failure
6 Recruiting The Hemodynamic Response to Prolonged Dobutamine Infusion
Conditions: Healthy;   Heart Failure
Intervention: Drug: 3 hours intravenous Dobutamine
Outcome Measures: Heart rate;   Systolic blood pressure
7 Not yet recruiting Levosimendan Versus Dobutamine in Cardiopatic Patients Undergoing Major Non Cardiac Surgery
Condition: Cardiovascular Diseases
Interventions: Drug: Levosimendan;   Drug: Dobutamine
Outcome Measure: cardiac index
8 Unknown  Levosimendan Versus Dobutamine in Shock Patients
Conditions: Cardiogenic Shock;   Septic Shock
Interventions: Drug: Levosimendan;   Drug: Dobutamine
Outcome Measures: Resolution of shock state;   Change in cardiac functions
9 Unknown  Assessment of HyperQ Signal for Detecting Ischemia During Dobutamine Stress ECG
Condition: Myocardial Ischemia
Intervention: Device: HyperQ Signal recording
Outcome Measures: HyperQ Signal recorded during the DES Test;   DES Outcome/ Angiography
10 Recruiting Assessment of Hemodynamic Response in Cardiopulmonary Bypass Graft After Cardiopulmonary Bypass Using Transesophegeal Echocardiography
Condition: Cardiopulmonary Bypass Graft
Intervention: Drug: epinephrine,Dobutamine, milrinone, levosimendan
Outcome Measures: Systolic and diastolic heart function;   Mortality after CABAG
11 Not yet recruiting NeoAdapt 2: An Observational Study Investigating Novel Biomarkers in the Evaluation and Treatment of Neonatal Circulatory Insufficiency
Condition: Circulatory Failure
Intervention:
Outcome Measures: Superior Vena Cava Flow (SVCF) in infants older than 33 weeks gestational age receiving intensive care;   Pleth Variability Index (PVI) in infants older than 33 weeks gestational age receiving intensive care;   Pharmacokinetic data for the elimination half life of Dobutamine when it is used for circulatory failure in infants older than 33 weeks gestational age.;   SVCF and PVI values correlation to each other and to parameters that assess circulatory status such as mean blood pressure and capillary refill time;   SVCF and PVI values relationship to clinical outcomes;   SVCF and PVI values and Dobutamine treatment for circulatory failure
12 Not yet recruiting Impact of Cardiac Blood Flow on Cerebral Blood Flow in Patients With Severe Traumatic Brain Injury
Condition: Severe Traumatic Brain Injury With High Cerebral Pressure
Interventions: Drug: Norepinephrine;   Drug: Dobutamine and norepinephrine
Outcome Measures: Mean blood flow velocity;   Evolution of brain oxygenation under treatment;   Dobutamine doses;   Resistivity index on renal doppler;   Pulsatility index on renal doppler;   Cardiac output modifications
13 Recruiting Reduced Contractile Reserve: a Therapeutic Target in Heart Failure With Preserved Ejection Fraction(HFpEF)
Conditions: Heart Failure With Preserved Ejection Fraction;   Pulmonary Disease;   Left Ventricular Hypertrophy/Hypertension
Interventions: Drug: Dobutamine;   Drug: Amlodipine
Outcome Measures: Change in ejection fraction with 5mcg/kg/min Dobutamine;   Change in pulse wave velocity
14 Recruiting Study of Effects of Sildenafil on Patients With Fontan Heart Circulation
Condition: Single Ventricle Heart Disease After Fontan Surgery.
Intervention: Drug: Dobutamine
Outcome Measures: end-systolic elastance;   end-diastolic pressure volume relationship
15 Recruiting Stress Echocardiography and Heart Computed Tomography (CT) Scan in Emergency Department Patients With Chest Pain
Conditions: Chest Pain;   Angina;   Angina Pectoris;   Coronary Artery Disease
Interventions: Procedure: Stress Echocardiography;   Procedure: Coronary CT Angiography
Outcome Measures: Hospital admission;   Emergency Department length of stay;   Hospital length of stay;   Estimated cost of initial care;   Repeat visits to the Emergency Department;   Death;   Non-fatal myocardial infarction
16 Available Prospective Analysis and Comparison of Stress Echo to Real-Time Myocardial Contrast Stress Echo
Condition: Evaluation of Troponin I Levels
Intervention: Other: Dobutamine: Perflutren Lipid Microsphere
Outcome Measure:
17 Recruiting The Influence of Beta Blocker Therapy on the Hemodynamic Response to Inotrope Infusion in Patients With Acute Decompensated Heart Failure
Conditions: Acute Decompensated Heart Failure;   Heart Failure
Intervention:
Outcome Measure: Change in Fick Cardiac Index ( Fick CI) from baseline to maximum tolerated dose of inotrope therapy
18 Unknown  Microcirculation Guided Therapy Versus "Standard Treatment" of Severe Sepsis
Conditions: Severe Sepsis;   Microcirculation
Interventions: Drug: Dopamine;   Drug: Dobutamine;   Drug: enoximone;   Drug: nitroglycerine;   Drug: noradrenaline
Outcome Measures: Difference in SOFA (Sequential Organ Failure Assessment) score during the first 72 hours of treatment for severe sepsis;   Severity, decrease and duration of organ failure over the complete ICU stay;   Duration of organ support;   ICU and hospital length of stay;   ICU and hospital mortality;   Inflammatory response measured by IL-6/IL-10;   Plasma concentration of asymmetric dimethyl arginine (ADMA
19 Recruiting Technical Development of Cardiovascular Magnetic Resonance Imaging
Condition: Cardiovascular Disease
Intervention:
Outcome Measures: The overall objective of this protocol is to test and develop innovative new noninvasive MRI techniques suitable for evaluating patients with cardiovascular disease.;   Technical Development of Multiecho MRI Methods;   Technical Developments Related to Distinguishing Fat and Water by MRI
20 Recruiting AC6 Gene Transfer for CHF
Condition: Congestive Heart Failure
Interventions: Drug: Ad5.hAC6;   Drug: Sucrose (3%)
Outcome Measures: Combined: a) Exercise treadmill time; b) LV function by echocardiography before and during Dobutamine infusion; c) Rate of LV pressure development and decline (dP/dt and -dP/dt) before and during Dobutamine infusion.;   Symptoms (KCCQ); hemodynamics; ICD discharge frequency

These studies may lead to new treatments and are adding insight into Dobutamine etiology and treatment.

A major focus of Dobutamine research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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