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Dovonex Medical Research Studies

Up-to-date List of Dovonex Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Dovonex Medical Research Studies

Rank Status Study
1 Recruiting Actinic Keratosis Study
Condition: Actinic Keratosis
Interventions: Drug: 5-fluorouracil 5% cream;   Drug: Calcipotriol 0.005% ointment;   Drug: Vaseline
Outcome Measures: percentage of change in the number of actinic keratoses from baseline;   complete and partial (>75%) clearance of actinic keratoses;   Composite score of erythema, itching and skin pain after topical 5-fluorouracil+calcipotriol vs. 5-fluorouracil alone treatment of actinic keratoses;   Induction of TSLP expression in keratinocytes by calcipotriol;   differences in response to topical 5-fluorouracil+calcipotriol vs. 5-fluorouracil alone between the four anatomical sites
2 Unknown  The Role of Calcipotriol as Radioprotector of Skin
Condition: Radiodermatitis
Intervention: Drug: Calcipotriol
Outcome Measures: Prevention of radiodermatitis;   Side effects of Calcipotriol
3 Not yet recruiting LEO 90100 Aerosol Foam Compared to Calcipotriol Plus Betamethasone Dipropionate Gel in Subjects With Psoriasis Vulgaris
Condition: Psoriasis Vulgaris (Plaque Psoriasis)
Interventions: Drug: LEO 90100 aerosol foam;   Drug: Aerosol foam vehicle;   Drug: Calcipotriol BDP gel;   Drug: Gel vehicle
Outcome Measure: Treatment success according to the PGA
4 Recruiting To Evaluate the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of Calcipotriene 0.005%, Applied Under Maximal Use Conditions in 12-16 Year Olds With Plaque Psoriasis
Condition: Psoriasis
Intervention: Drug: calcipotriene
Outcome Measures: Effect of calcium metabolism;   Pharmacokinetics
5 Unknown  Nickel Desensitization Using Topical Therapy
Condition: Allergic Contact Dermatitis
Intervention: Drug: Calcipotriol, Betamethasone, Calcipotriol & Betamethasone
Outcome Measures: Change in contact dermatitis response to nickel allergen at 5 weeks after topical desensitization;   Change in immune cell profile of patients 5 weeks after nickel desensitization
6 Recruiting To Evaluate the Safety, Tolerability and Efficacy of Calcipotriene Foam, 0.005%, Versus Vehicle Foam in Pediatric Subjects (Ages 2-11) With Plaque Psoriasis
Condition: Psoriasis
Interventions: Drug: STF 115469 Foam;   Drug: Vehicle Foam
Outcome Measures: treatment success;   erythema;   scaling;   plaque thickness
7 Not yet recruiting Effect of Calcipotriol Plus Betamethasone Dipropionate Gel on the HPA Axis and Calcium Metabolism in Adolescent Subjects (Aged 12 to 16 Years, 11 Months) With Scalp and Body Psoriasis
Condition: Psoriasis Vulgaris
Intervention: Drug: LEO 80185
Outcome Measures: Adverse Drug Reactions (ADRs);   Subjects with serum cortisol concentration of ≤18 mcg/dl at 30 minutes after ACTH-challenge;   Change in albumin-corrected serum calcium from baseline (SV2);   Change in 24-hour urinary calcium excretion from baseline (SV2)
8 Unknown  Regulatory T-cells in Psoriasis Patients as Targets for Therapy
Condition: Psoriasis
Intervention: Drug: Dovobet, neotigason, etanercept, adalimumab. infliximab
Outcome Measure: Clincal-immunological correlation of treatment outcome in psoriasis patients
9 Recruiting Efficacy Study Comparing Topical M518101 and Vitamin D3 in Adult Psoriasis Patients
Condition: Plaque Psoriasis
Intervention: Drug: M518101
Outcome Measures: Severity of psoriasis;   Duration of response following 8 week treatment
10 Recruiting Vitamin D Supplementation in Polymorphic Light Eruption
Condition: Polymorphic Light Eruption
Interventions: Drug: Oral Vitamin D 3;   Drug: Miglyol 812 N
Outcome Measures: PLE test score (from 0-12) of experimental photo provocation;   Cytokine levels in serum;   Chemotaxis of neutrophils;   Level of regulatory T cells;   Quantification of skin alterations, including cellular infiltration and cytokine profile;   Dermatological quality of life (DLQI);   HADS (hospital anxiety and depression scale);   Function of regulatory T cells

These studies may lead to new treatments and are adding insight into Dovonex etiology and treatment.

A major focus of Dovonex research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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