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Doxycycline Medical Research Studies

Up-to-date List of Doxycycline Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Doxycycline Medical Research Studies

Rank Status Study
1 Not yet recruiting Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease
Conditions: Kawasaki Disease;   Coronary Aneurysm
Interventions: Drug: Doxycycline;   Drug: Standard care
Outcome Measures: Coronary artery diameter change;   Assess the change in MMP-9 level;   Assess a change in TIMP level
2 Unknown  Effectiveness of Doxycycline for Treating Pleural Effusions Related to Cancer in an Outpatient Population
Condition: Malignant Pleural Effusion
Interventions: Drug: Doxycycline;   Other: normal saline
Outcome Measures: Time to pleurodesis;   Pleurodesis rates at 90 days post Pleurx insertion;   Number of participants with adverse events;   Effects on pulmonary function
3 Unknown  Safety, Efficacy and Pharmacokinetics of Doxycycline Plus Tauroursodeoxycholic Acid in Transthyretin Amyloidosis
Condition: Transthyretin Amyloidosis
Intervention: Drug: Doxycycline + Tauroursodeoxycholic acid
Outcome Measures: Response rate to Doxycycline + tauroursodeoxycholic acid treatment;   Number of patients experiencing treatment-emergent adverse events;   Change in quality of life;   Doxycycline pharmacokinetics (PK);   response in autonomic dysfunction, sensory-motor peripheral neuropathy and visceral organ involvement;   neurologic response;   Incidence of patients discontinuing from the study because of clinical or laboratory adverse events
4 Recruiting Doxycycline in Therapy of Erythema Migrans
Condition: Lyme Borreliosis
Intervention: Drug: Doxycycline
Outcome Measures: Comparing of objective sequelae and post-treatment subjective symptoms in three groups of erythema migrans patients treated with Doxycycline: with no accompanying symptoms, with mild and with severe symptoms at the beginning.;   Comparison of subjective symptoms between erythema migrans patients treated with Doxycycline and control subjects without a history of Lyme borreliosis.
5 Recruiting Combining Doxycycline With Bone-Targeted Therapy in Patients With Metastatic Breast Cancer
Condition: Pain
Intervention: Drug: Doxycycline
Outcome Measures: palliative benefit;   changes to bone formation markers
6 Recruiting Safety and Efficacy of Doxycycline in Patients With Non-Ischemic Cardiomyopathy
Conditions: Non-ischemic Cardiomyopathy;   Systolic Heart Failure (NYHA II-III)
Interventions: Drug: Doxycycline;   Drug: placebo
Outcome Measure: Peak aerobic exercise capacity
7 Recruiting Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study
Conditions: Chronic Pelvic Pain Syndrome;   Bladder Pain Syndrome
Interventions: Drug: Doxycycline;   Drug: placebo
Outcome Measures: Change in the O'Leary-Sant IC symptom and problem index total score from baseline;   Changes of patient reported pain, urgency, frequency, functional bladder capacity documented in 72-hour pain and bladder diary, completed during the 3 days before the particular follow-up visit.;   Changes in sexual function assessed by the Female Sexual Function Index (FSFI) at the time of the particular follow-up visit
8 Unknown  Double-blind-randomized,Placebo Controlled Trial for Chemotherapy-associated Oral Mucositis Using Doxycycline Hyclate
Condition: Mucositis
Intervention: Drug: Doxycycline hyclate
Outcome Measures: Complete response;   Partial resolution of oral lesions, incidence of infections and mortality.
9 Unknown  Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD)
Conditions: Chronic Obstructive Pulmonary Disease;   Inflammation;   Pulmonary Emphysema
Interventions: Drug: Doxycycline;   Drug: Placebo
Outcome Measures: myeloperoxidase in induced sputum;   MMP-8, MMP-9, IL-6 levels and differential cell counts in induced sputum.;   Lung function (FEV1);   Symptom scores
10 Recruiting Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy
Condition: Thyroid Associated Opthalmopathies
Interventions: Drug: Prednisone+placebo of Doxycycline;   Drug: Doxycycline+placebo of Prednisone
Outcome Measures: Overall treatment response;   • Health related quality of life questionnaires (GO-QoL);   • Safety and tolerability as assessed by adverse events, vital signs;   • Quantitative changes of rectus diameter measured by MRI scan;   Relapse
11 Recruiting Effect of a Commonly Used Antibiotic, Doxycycline, in Women With Polycystic Ovarian Syndrome
Conditions: Polycystic Ovarian Syndrome (PCOS);   Irregular Menstrual Cycles;   Androgen Excess
Interventions: Drug: Doxycycline;   Drug: Sugar Pill
Outcome Measures: Assess the effectiveness of daily Doxycycline use in the primary outcome of reduction of serum testosterone and in women with PCOS during and beyond the treatment course.;   Assess the effectiveness of daily Doxycycline use in the secondary outcome of restoring ovulation in women with PCOS during and beyond the treatment course.
12 Unknown  Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis
Condition: Suspected Early Lyme Neuroborreliosis
Interventions: Drug: Doxycycline;   Drug: ceftriaxone
Outcome Measure: Objective sequelae and post-treatment subjective symptoms in patients treated for suspected early Lyme neuroborreliosis with normal CSF cell count with Doxycycline or ceftriaxone for 14 days.
13 Recruiting Doxycycline, Temozolomide and Ipilimumab in Melanoma
Condition: Melanoma
Interventions: Drug: Doxycycline;   Drug: Ipilimumab;   Drug: Temozolomide
Outcome Measure: Overall Response Rate
14 Unknown  Oral Contraceptives and Subantimicrobial Doxycycline: Effect on Endometrial MMPs
Condition: Breakthrough Bleeding
Intervention: Drug: Doxycycline
Outcome Measures: Determine the effect of combined oral contraceptives on endometrial MMP expression.;   Determine the effect of sub-antimicrobial Doxycycline on MMP expression and activity in continuous oral contraceptive users.
15 Recruiting Antibiotic Treatment of Multiple Erythema Migrans
Condition: Multiple Erythema Migrans
Interventions: Drug: ceftriaxone;   Drug: Doxycycline;   Other: erythema migrans patients treated with Doxycycline
Outcome Measures: Objective sequelae and post-treatment subjective symptoms such as fatigue, malaise, arthralgias, headache, myalgias, paresthesias, dizziness, or irritability in patients treated for multiple erythema migrans with ceftriaxone or Doxycycline for 15 days.;   Comparison of subjective symptoms such as fatigue, malaise, arthralgias, headache, myalgias, paresthesias, or irritability between patients treated with antibiotic for multiple erythema migrans and control subjects without a history of Lyme borreliosis.;   Objective sequelae and post-treatment subjective symptoms such as fatigue, malaise, arthralgias, headache, myalgias, paresthesias, dizziness, or irritability in patients with solitary versus multiple erythema migrans after antibiotic treatment.
16 Recruiting A Phase II Study of Doxycycline in Relapsed NHL
Conditions: Adult Diffuse Large B-Cell Lymphoma;   Mantle Cell Lymphoma Recurrent;   Lymphoma, Follicular;   Marginal Zone B-Cell Lymphoma;   Malignant Lymphoma - Lymphoplasmacytic;   Waldenstrom Macroglobulinemia;   Small Lymphocytic Lymphoma;   Chronic Lymphocytic Leukemia (CLL);   T-Cell Lymphoma
Intervention: Drug: Doxycycline
Outcome Measures: Overall response rate;   Progression free survival
17 Unknown  The Effect of Doxycycline 100mg and Doxycycline 20mg in Treatment of Mild and Moderate Acne
Conditions: Acne;   Inflammation
Intervention: Drug: Doxycycline
Outcome Measure:
18 Recruiting Doxycycline for COPD in HIV-Infected Patients
Conditions: HIV;   Chronic Obstructive Pulmonary Disease (COPD);   Emphysema
Intervention: Drug: Doxycycline
Outcome Measures: Safety and tolerability;   Larger phase II clinical trial
19 Recruiting Tolerability and Efficacy of a Combination of Doxycycline and TUDCA in Patients With Transthyretin Amyloid Cardiomyopathy
Conditions: Amyloidosis; Heart (Manifestation);   Senile Cardiac Amyloidosis
Intervention: Drug: Tauroursodeoxycholic Acid and Doxycycline
Outcome Measures: The rate of progression of transthyretin cardiac amyloidosis, as measured by changes in strain echocardiography, in a group of patients taking a combination of Doxycycline and TUDCA.;   Number of patients with adverse events to the medications over the period of therapy (18 months);   To evaluate general and health related quality of life (QoL) in SSA and ATTR subjects.
20 Recruiting Management of Etonogestrel Subdermal Implant-related Bleeding
Condition: ESI-related Bleeding
Interventions: Drug: Doxycycline;   Drug: Placebo
Outcome Measures: Efficacy and safety of Doxycycline compared to placebo for unacceptable bleeding;   Patient Satisfaction;   Method Continuation rate

These studies may lead to new treatments and are adding insight into Doxycycline etiology and treatment.

A major focus of Doxycycline research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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