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Dyspnoea Medical Research Studies

Up-to-date List of Dyspnoea Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Dyspnoea Medical Research Studies

Rank Status Study
1 Recruiting Improving Management of Breathlessness in Patients With Lung Cancer
Conditions: Breathlessness;   Dyspnea;   Lung Cancer
Intervention: Behavioral: Cognitive Behavioral Intervention for Breathlessness
Outcome Measures: Feasibility and acceptability of a nurse practitioner-delivered dyspnea management intervention in patients with advanced lung cancer;   Effect of a nurse practitioner-delivered dyspnea management intervention on breathlessness in patients with advanced lung cancer;   Effect of a nurse practitioner-delivered dyspnea management intervention on quality of life in patients with advanced lung cancer;   Effect of a nurse practitioner-delivered dyspnea management intervention on mood symptoms in patients with advanced lung cancer
2 Unknown  Trial of a Breathlessness Intervention Service for Intractable Breathlessness
Condition: Dyspnea
Interventions: Behavioral: Breathlessness Intervention Service;   Behavioral: Best supportive care (Standard Care)
Outcome Measures: Numerical rating Scale (NRS) for distress due to breathlessness;   Modified BORG;   NRS Breathlessness at best/worst;   Dyspnoea descriptors;   CRQ;   EQ-5D;   HADS;   CSRI;   Charlson Co-morbidity score;   Social Functioning;   Karnofsky;   Experience of breathlessness and expectations/views of BIS;   Burden interview and caregiver Appr scale
3 Recruiting Mechanisms of Exertional Dyspnea in Fibrotic Interstitial Lung Disease
Conditions: Lung; Disease, Interstitial, With Fibrosis;   Healthy
Interventions: Other: Room air (21% oxygen);   Other: Hyperoxia (60% oxygen)
Outcome Measures: To determine the physiological mechanisms of exertional dyspnea in patients with fibrotic ILD;   To determine the mechanism by which hyperoxia improves exertional dyspnea and exercise time;   To determine any physiological mechanistic differences of exertional dyspnea between participants with fibrotic ILD and healthy control participants.
4 Recruiting Evaluating Sensations of Breathlessness in Patients With Cystic Fibrosis
Conditions: Lung; Disease;   Cystic Fibrosis;   Healthy
Intervention:
Outcome Measures: To determine if dyspnea is qualitatively and quantitatively different in patients with cystic fibrosis compared with age and sex-matched healthy controls during exercise;   To determine if the dyspnea responses can be explained by differences in the ventilatory response to exercise.
5 Unknown  Vibration Response Imaging (VRI) in Dyspnea Patients Presenting to the ED
Condition: Dyspnea
Intervention:
Outcome Measures: Assess the ability of the VRI to improve clinical outcomes via accurate, early classification of the cause of acute dyspnea as HF or other (i.e. COPD, PE etc).;   Assess the agreement to aid in classifying the cause of acute dyspnea as HF or other of the VRI in comparison to BNP/NTproBNP assays.;   Assess the ability of the VRI to aid in classifying the cause of acute dyspnea as HF or COPD;   Evaluate the ability of the VRI to monitor changes in clinical status following treatment in comparison with other standard testing methods (e.g. ECG, serial chest x-rays, etc.)
6 Recruiting Prehospital Triage of Patients With Severe Shortness of Breath Using Biomarkers
Condition: Dyspnea
Intervention: Other: Supplementary NT-proBNP measurement
Outcome Measures: Proportion of patients with dyspnea caused by heart disease initially triaged to department of cardiology;   Proportion of patients with dyspnea of other etiologies initially triaged to department of cardiology;   Proportion of patients with dyspnea caused by heart disease that receives pulmonary medication;   Length of hospital stay;   Intensive care unit admission rate;   All-cause re-admission;   Proportion of patients not admitted to hospital;   All-cause mortality;   Proportion of patients with dyspnea caused by lung disease, that receives traditional heart failure medication;   Proportion of patients with correct diagnosis of congestive heart failure in the prehospital setting;   Proportion of patients where congestive heart failure is correctly disproved in the prehospital setting
7 Recruiting Self-Management Intervention for Breathlessness in Lung Cancer
Conditions: Lung Cancer;   Breathlessness
Intervention: Behavioral: Self-management Intervention
Outcome Measures: Perceived severity of breathlessness;   Affective distress of breathlessness;   Dyspnea with activities of daily living and exercise;   Self-efficacy and mastery for managing breathlessness;   Beliefs about breathlessness;   Adherence and Use of Self-Management Strategies;   Exercise capacity;   Psychological distress;   Quality of life;   Health care utilization
8 Recruiting Aerosol Inhalation Treatment for Dyspnea
Conditions: Healthy;   Dyspnea
Intervention: Drug: Furosemide
Outcome Measures: Subject rating of Breathing Discomfort (dyspnea);   Multidimensional Dyspnea Profile;   Urine output
9 Recruiting Sensitivity of the Step Test to Detect Improvement in Dyspnea Following Bronchodilation in Patients With Chronic Obstructive Pulmonary Disease
Conditions: Moderate Chronic Obstructive Pulmonary Disease;   Severe Chronic Obstructive Pulmonary Disease;   Dyspnea
Intervention: Drug: Combination ipratropium/salbutamol or placebo (nebulization)
Outcome Measures: Symptom perception;   Cardiac and ventilatory outcomes;   Inspiratory capacity;   Respiratory pressures and diaphragm EMG;   Pulmonary function;   Maximal oxygen consumption;   Maximal inspiratory pressure (PImax)
10 Not yet recruiting Understanding the Importance of Plasticity in the Brain Mechanisms of Dyspnoea Perception
Condition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: d-cycloserine;   Drug: placebo
Outcome Measures: BOLD signal changes;   Grey matter volume
11 Unknown  The Use of a Handheld Fan to Manage Breathlessness - A Feasibility Study
Condition: Dyspnea
Intervention: Device: handheld fan directed to cheeks
Outcome Measures: Primary outcome measure is time in minutes for which breathlessness is improved after 5 minutes use of the fan directed at the face;   Relief from breathlessness noted on relief score after using the handheld fan;   Correlation between VAS and NRS scales
12 Recruiting Acupuncture Feasibility Trial for Dyspnea in Lung Cancer
Conditions: Lung Cancer;   Dyspnea
Intervention: Procedure: Acupuncture
Outcome Measure: Dyspnea
13 Recruiting Study of a Tiotropium Inhaler For Shortness of Breath in Advanced Non-Small Cell Lung Cancer
Conditions: NSCLC;   Dyspnea
Interventions: Drug: Tiotropium;   Drug: Placebo
Outcome Measures: 12 question Cancer Dyspnea Scale;   10 point Dyspnea numeric scale;   10 point Cough scale;   Forced Expiratory Volume 1 second (L/s) and Forced Vital Capacity (L)
14 Recruiting EUROpean Dyspnoea Survey in the EMergency Departments
Conditions: Dyspnea;   Emergencies
Intervention:
Outcome Measures: All cause mortality;   All cause rehospitalization
15 Recruiting Registry of Patients With Acute Dyspnea in the Emergency Department
Conditions: Dyspnea;   Heart Failure;   COPD
Intervention:
Outcome Measures: all cause mortality;   demographics and baseline characteristics;   medical care processes;   subjective and objective risk assessment
16 Recruiting Basics in Acute Shortness of Breath EvaLuation (BASEL V) Study
Condition: Dyspnea
Intervention:
Outcome Measures: Diagnostic accuracy for the diagnosis of heart failure;   Prognostic utility in patients with dyspnea
17 Not yet recruiting Dyspnea in COPD: Relationship With Exacerbations Frequency
Condition: Dyspnea
Interventions: Procedure: Spirometry;   Procedure: CO Exhaled breath;   Procedure: P01;   Procedure: FeNO
Outcome Measures: The negative airway pressure generated during the first 100 ms of an occluded inspiration, which is an estimation of the neuromuscular drive to breathe. (P01 );   Borg scale;   Fractional exhaled nitric oxide (FeNO);   Inspiratory capacity (IC);   Ventilation at rest;   CO exhaled test
18 Recruiting Treatment of Dyspnea in Do-not-intubate Patients
Conditions: Acute Respiratory Failure;   Acute on Chronic Respiratory Failure;   Dyspnea
Interventions: Device: NIV;   Device: CPAP;   Device: Standard oxygen;   Device: HFNC
Outcome Measures: Prevalence of use of Noninvasive ventilation in DNI patients;   Subjects' comfort;   Dyspnea score;   Family members' impressions;   Family member's impressions
19 Not yet recruiting Inhaled Furosemide & Dyspnea
Condition: Dyspnea
Interventions: Other: CWS;   Drug: Furosemide;   Drug: Placebo
Outcome Measure: Sensory intensity (Borg 0-10 scale) ratings of dyspnea at isotime
20 Recruiting Inhaled Ondansetron & Dyspnea
Condition: Dyspnea
Interventions: Drug: Ondansetron;   Other: CWS;   Drug: Placebo
Outcome Measure: Sensory Intensity (Borg 0-10 scale) ratings of dyspnea at isotime

These studies may lead to new treatments and are adding insight into Dyspnoea etiology and treatment.

A major focus of Dyspnoea research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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