Up-to-date List of Dystonia Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Dystonia Medical Research Studies

RankStatusStudy
1 Recruiting Neuroimaging of Dystonia
Conditions: Primary Cervical Dystonia; DYT 1 Dystonia
Interventions: Drug: Primary Cervical Dystonia (Trihexyphenidyl);   Other: Controls Primary Cervical Dystonia (Trihexyphenidyl);   Other: DYT 1 Dystonia (Healthy Control);   Other: DYT 1 Dystonia
Outcome Measures: Change in cerebral blood flow based on blood-oxygen-level dependent (BOLD) contrast during a precision gripping task;   Change in cerebral blood flow based on blood-oxygen-level dependent (BOLD) contrast during a precision gripping task after administration of trihexyphenidyl compared to change in BOLD contrast during a precision gripping task
2 Recruiting Insights Into Deep Brain Stimulation (DBS) for Cervical Dystonia
Condition: Cervical Dystonia
Intervention: Procedure: Transcranial magnetic stimulation (TMS)
Outcome Measures: The body's response to transcranial magnetic stimulation (TMS);   Clinical assessment of Dystonia severity
3 Unknown  Somatosensory Processing in Focal Hand Dystonia
Conditions: Focal Hand Dystonia;   Musician's Dystonia;   Writer's Cramp;   Dystonic Cramp
Interventions: Other: Tactile training + sham rTMS;   Other: Tactile training + rTMS
Outcome Measures: Dystonia Rating Scale;   Neuroimaging maps of digit representation
4 Recruiting Dystonia Coalition Projects
Conditions: Dystonia;   Voice Disorders
Intervention:
Outcome Measure: Observational
5 Recruiting Ampicillin for DYT-1 Dystonia Motor Symptoms
Conditions: DYT-1;   Dystonia
Interventions: Drug: Ampicillin;   Drug: Sugar pill
Outcome Measures: Safety and tolerability of Ampicillin in treating DYT-1 Dystonia;   Burke-Fahn Marsden Dystonia Rating Scale (BFM-DRS)
6 Unknown  Cerebellum and Cortical Plasticity: the Case of Dystonia
Condition: Dystonia
Intervention: Other: Transcranial magnetic stimulation
Outcome Measures: Comparison of MEP0/MEP10 and MEP0/MEP30 values obtained after sham, cRTBS or iTBS of the cerebellum.;   Variation of the appropriate dystonic clinical score (depending on the type of Dystonia) after each rTMS session (cTBS, iTBS, sham).;   Measurement of number of errors, mean time to reach the target after each rTMS session (cTBS, iTBS, sham).;   Measurement of the variation of the motor threshold, intracortical inhibition and intracortical facilitation after each rTMS session (cTBS, iTBS, sham).
7 Unknown  Foot Dystonia Treatment by Botulinum Toxin Injections in Parkinson Disease : Efficiency of Injections Made in Extrinsic Muscle (Flexor Digitorum Longus Muscle) Compared to Intrinsic Muscle (Flexor Digitorum Brevis or Quadratus Plantae Muscles)
Conditions: Parkinson's Disease;   Foot Dystonia
Interventions: Drug: Botulinum Toxin: Xeomin;   Drug: Placebo
Outcome Measures: In a controlled double blind and randomized study, we want to show that intramuscular injections of botulinum toxin are beneficial to reduced Dystonia and associated pain in patient with foot Dystonia (compared to placebo injections).;   Efficiency comparison of injections made in leg muscle (Flexor digitorum longus) between injections made directly in foot muscle (Flexor digitorum brevis or quadratus plantae) - Effects of injections on pain and quality of life.
8 Recruiting Dysport for the Treatment of OMD
Conditions: Oral Dystonia;   Tardive Dystonia
Intervention: Drug: AbobotulinumtoxinA
Outcome Measures: Global Dystonia Rating Scale;   Analogue Pain Scale;   SCS-PD (Sialorrhea Clinical Scale for PD);   Estimated amount of tongue bites per day;   Swallowing Disturbance Questionnaire(SDQ);   Fahn-Marsden Part B "Speech" Question;   Oromandibular Dystonia Quality of Life Questionnaire (OMDQ-25);   Global Clinical Impression Scale (CGI) with Efficacy Index;   Unified Dystonia Rating Scale (UDRS)
9 Recruiting Functional Connectivity in Primary Focal Dystonia
Condition: Dystonia
Intervention:
Outcome Measures: A second level contrast between Primary Focal Dystonia (PFD) and Healthy Controls (HC) of the statistical parametric maps of correlation coefficients at rest and during a tapping motor task;   Strength of correlation between basal ganglia motor network functional connectivity measures and total PFD clinical assessment scale scores;   Lateralization;   Statistical dependence between symptoms and measures of basal ganglia functional connectivity
10 Unknown  Effects of Botulinum Toxin in Cervical Dystonia
Conditions: Torticollis;   Cervical Dystonia
Intervention: Drug: Botulinum Toxin A
Outcome Measures: Evidence of Cortical organizational changes with botulinum toxin treatment in patients with torticollis utilizing magnetoencephalography;   Tsui Torticollis Rating scale
11 Recruiting Effect of Increasing Motor Cortex Inhibition on Task Specific Dystonia
Condition: Dystonia
Intervention: Device: Transcranial Magnetic Stimulation
Outcome Measure: Efficacy of TMS on task-specific focal hand Dystonia
12 Recruiting Transcranial Magnetic Stimulation for Focal Hand Dystonia
Condition: Dystonia
Intervention:
Outcome Measure: Motor evoked potential following TMS conditioning versus the baseline MEP amplitude in Dystonia patients and healthy subjects.
13 Recruiting Analysis of Three-dimensional Movements of the Head in Cervical Dystonia
Condition: Cervical Dystonia
Intervention:
Outcome Measures: Range of motion of the voluntary mobility of the cervical spine in the three spatial planes;   movements disorders in cervical Dystonia;   head posture;   range of motion
14 Not yet recruiting ASIS for Botox in Cervical Dystonia
Conditions: Cervical Dystonia Adults ,;   Abnormal Head Position and Neck Pain for These 7 Muscle Groups: Splenius,Scalene,Sterno-cleido-mastoid,Levator Scapulae,Semispinalis,Trapezius,and Longissimus.
Interventions: Drug: Gadolinium;   Drug: Efficacy of Botox intramuscularly at Week 6;   Drug: Efficacy of Botox intramuscularly at Week 12;   Drug: Efficacy of Botox intramuscularly at Week 18;   Drug: Efficacy of Botox intramuscularly at Week 24;   Drug: Efficacy of Botox intramuscularly at Week 30;   Drug: Efficacy of Botox subdermally at Week 6;   Drug: Efficacy of Botox subdermally at Week 12;   Drug: Efficacy of Botox subdermally at Week 18;   Drug: Efficacy of Botox subdermally at Week 24;   Drug: Efficacy of Botox subdermally at Week 30;   Drug: Adverse Reactions of Botox intramuscularly;   Drug: Adverse Reactions of Botox subdermally
Outcome Measures: Relative Prolongation Ability Score for Gadolinium subdermally injected.;   Efficacy of Botox intramuscularly vs. subdermally in Cervical Dystonia.
15 Unknown  Alteration of Deep Brain Stimulation Parameters for Dystonia
Condition: Dystonia
Intervention: Procedure: Alteration of deep brain stimulator settings
Outcome Measures: To assess if the stimulation frequency of 60 Hz is superior to 130 Hz for patients with primary Dystonia who have responded poorly to standard 130 Hz pallidal stimulation;   Assess any potential changes in anxiety, mood, cognition
16 Unknown  Efficacy and Safety of Deep Brain Stimulation (DBS) of the Pallidal (GPi) in Patients With Tardive Dystonia
Conditions: Dystonia;   Movement Disorder
Intervention: Procedure: deep brain stimulation
Outcome Measures: Improvement of the motor scale of Burke-Fahn-Marsden-Dystonia Rating Scale via blinded video assessment 3 months after starting DBS in comparison to sham-stimulated patients;   AIMS;   Non-motor subscores of BMFDRS;   Visual analogue scales for both patients and treating physicians;   Quality of life (SF-36);   Psychiatric assessment (HADS-D and PANSS)
17 Recruiting Efficacy Trial of Zonisamide for Myoclonus Dystonia
Condition: Myoclonus Dystonia
Interventions: Drug: zonegran;   Drug: placebo
Outcome Measures: Measure of the evolution of the severity of myoclonus by a specific scale (UMRS);   Measure of the evolution of the severity of Dystonia by a specific scale (BFM);   measure of the evolution of the severity of myoclonus by electromyographic recording
18 Recruiting Brain Anatomy in Dystonia
Conditions: Dystonia;   Healthy
Intervention:
Outcome Measure:
19 Recruiting Can Short Latency Afferent Inhibition Give us Clues to Better DYT 1 Dystonia Treatments?
Conditions: DYT-1;   DYT1;   DYT 1;   Dystonia
Intervention:
Outcome Measures: Change in amplitude, at 3 and 6+ months, of motor evoked potentials (MEPs) with median nerve stimulation (SAI) and simultaneous median nerve and ulnar nerve stimulation (SAIdualstim);   Correlation of change in evoked potential amplitudes and clinical measures at 3 and 6+ months
20 Recruiting Incobotulinum Toxin A (Xeomin®) As A Treatment For Focal Task-Specific Dystonia Of The Musician's Hand
Condition: Dystonia
Intervention: Drug: incobotulinumtoxin A
Outcome Measures: Patient and Physician Global Perception of change;   Quantitative MIDI Analysis comparison;   Blinded high speed video analysis comparison;   Perceived Stress Scale;   Motor Strength comparison

These studies may lead to new treatments and are adding insight into Dystonia etiology and treatment.

A major focus of Dystonia research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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