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ESSURE Medical Research Studies

Up-to-date List of ESSURE Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest ESSURE Medical Research Studies

Rank Status Study
1 Recruiting Airway Pressure Release Ventilation (APRV) Compared to ARDSnet Ventilation
Conditions: Acute Lung Injury;   Adult Respiratory Distress Syndrome;   Kidney Injury
Interventions: Device: Volume-Cycled Assist-Control (AC) mode;   Device: Airway Pressure Release Ventilation (APRV) mode
Outcome Measures: All cause mortality;   Number of ventilator-free days;   Length of ICU stay and /or Total hospital days;   To determine the effects of APRV ventilation versus ARDS net low volume-cycle ventilation on the incidence of of AKI;   To determine the effects of APRV ventilation versus ARDS net low volume-cycle ventilation on the NGAL, KIM-1, and IL-18 urine biomarkers for AKI;   To determine the effects of APRV ventilation versus ARDS net low volume-cycle ventilation in maintaining hourly urine output > 0.5 mls/kg/hr;   Will determine urinary aquaporin-2 levels in patients randomized to APRV ventilation versus ARDS net low volume-cycle ventilation
2 Unknown  Comparison of Continuous Non-invasive Pressure Device Versus Invasive Pressure Measurement During Prehospital Emergency
Condition: Blood Pressure
Intervention: Device: CNAP-Monitor
Outcome Measure: agreement with invasive blood Pressure
3 Unknown  Comparison of Pressure Support and Pressure Control Ventilation in Chronic Respiratory Failure
Conditions: COPD;   Chest Wall Disease;   Neuromuscular Disease;   Obesity Hypoventilation
Interventions: Other: Pressure support ventilation;   Other: Pressure control ventilation
Outcome Measures: Adherence to ventilation;   Arterial blood gases;   Health related quality of life as measured by CRQ and SRI;   Breathlessness (MRC dyspnoea score);   Assessment of daytime vigilance and fatigue by the Epworth sleepiness score,Oxford sleep resistance test and the fatigue severity score.;   Sleep comfort as assessed by a visual analogue scale;   Spirometry: forced expiratory volume in 1s and forced vital capacity;   Respiratory muscle strength: maximum inspiratory Pressure, maximum expiratory Pressure and sniff nasal Pressure;   Sleep fragmentation as assessed by actigraphy;   Patient ventilator synchrony as measured by number of ineffective efforts
4 Recruiting Pilot Study on Ambulatory Intraocular Pressure and Blood Pressure Monitoring in Glaucoma
Condition: Normal-Tension Glaucoma
Interventions: Device: Sensimed Triggerfish;   Device: Blood Pressure
Outcome Measures: Blood Pressure Trends;   Intraocular Pressure
5 Recruiting Efficacy of Lower Tourniquet Pressure During Total Knee Arthroplasty
Condition: Osteoarthritis
Interventions: Procedure: Low tourniquet Pressure;   Procedure: Conventional tourniquet Pressure
Outcome Measures: Acquisition of bloodless surgical field just after skin incision;   Failure of acquiring bloodless surgical field during operation;   Increasement of tourniquet Pressure to acquire bloodless surgical field;   Thigh pain on the site of tourniquet application;   Knee pain;   Skin problem on the site of tourniquet application;   Nerve palsy;   symptomatic venous-thromboembolism
6 Unknown  Effect of Nasal Continuous Positive Airway Pressure (CPAP) Blood Pressure and Vascular Endothelial Growth Factor in Obstructive Sleep Apnea Syndrome
Condition: Obstructive Sleep Apnea
Interventions: Device: Continuous positive airway Pressure (CPAP);   Device: Sham Continuous positive airway Pressure (CPAP)
Outcome Measures: Change in 24 hr mean blood Pressure at 3 months;   Changes in systolic and diastolic blood Pressure, changes in mean blood Pressure awake and asleep, change in plasma Vascular endothelia growth factor (VEGF) at 3 months;   Whether any change in blood Pressure or vascular endothelial growth factor (VEGF) is related to the baseline severity of obstructive sleep apnea (OSA) and continuous positive airway Pressure (CPAP) compliance over 3 months;   Epworth Sleepiness Scale (ESS) and Calgary Sleep Apnea Quality of Life Index (SAQLI) at 1 month and 3 months.
7 Not yet recruiting Comparison of Two Ventilation Modes With Laryngeal Mask Airway Guardian
Condition: Gynecologic Disease
Interventions: Procedure: tidal volume;   Procedure: peak airway Pressure
Outcome Measures: peak Pressure;   Blood Pressure;   heart rate
8 Recruiting Comparison Between Different Filling Pressures in Operative Outpatient Hysteroscopy
Condition: Hysteroscopy
Interventions: Device: Filling Pressure 80;   Device: Filling Pressure 50;   Device: Filling Pressure 40
Outcome Measures: Completing the procedure with the allocated Pressure;   Pain perception during the procedure;   Pain perception after the procedure
9 Recruiting The Intraocular Pressure Measured by Different Tonometers in Corneal Edema
Conditions: Intraocular Pressure;   Corneal Edema
Intervention: Other: Intraocular Pressure measurement
Outcome Measures: Intraocular Pressure;   Relationship between the central corneal thickness and intraocular Pressure measured by each tonometer
10 Unknown  The Effect of Two Airway Interventions, During One Lung Ventilation, on Blood Oxygen Content
Condition: Thoracic, Diseases
Interventions: Procedure: RM + Positive End Expiratory Pressure;   Procedure: Continuous Positive Airway Pressure
Outcome Measures: Partial Pressure of oxygen in blood;   Hypoxia;   Hypoxia intervention techniques
11 Unknown  Effect of Continuous Positive Airway Pressure (CPAP) Versus Auto-titrating Continuous Positive Airway Pressure (APAP) on Resistant Hypertension (HTN) and Arterial Stiffness
Conditions: Resistant Hypertension;   Obstructive Sleep Apnea
Interventions: Device: CPAP;   Device: APAP
Outcome Measures: 24 hour blood Pressure.;   Non-invasive measures of arterial stiffness using applanation tonometry.;   Standard measures of OSA severity, including AHI and measures of nocturnal oxygenation and sleep quality using polysomnography.;   Blood tests to assess levels of aldosterone, hsCRP, fasting glucose, HbA1c, and plasma insulin.
12 Unknown  Effect of Continuous Positive Airway Pressure (CPAP) on Systemic Blood Pressure, Coagulability and Carotid Intima-media Thickness in Patients With Sleep Apnea
Condition: Obstructive Sleep Apnoea
Interventions: Device: Continuous Positive Airway Pressure;   Other: Placebo
Outcome Measures: Blood Pressure measurement;   Changes in systolic and diastolic Blood Pressure between the 2 groups at 6 & 12 months;   serial changes of carotid intimal media thickness between the two treatment groups over 12 months;   serial changes in haemostatic assays
13 Recruiting Tongue Pressure Profile Training for Dysphagia Post Stroke
Condition: Dysphagia
Interventions: Behavioral: Tongue Pressure Profile Training;   Behavioral: Tongue-Pressure Strength-and-Accuracy Training
Outcome Measures: Change in Swallow Response Time for 5 cc thin liquid swallows;   Penetration-Aspiration Scale score for 5 cc thin liquid swallows;   Changes in tongue-palate Pressure amplitude for maximum isometric Pressures
14 Not yet recruiting Preliminary Study Leading to Prevention of Pressure Ulcers by the Use of an On-board Device : Ergonomic Assessment of Wheelchair-seat Pressures in Spinal Cord Injured (SCI) Patients ( PRESDIE)
Condition: Pressure Ulcers
Intervention: Device: TexiMat
Outcome Measures: Intra- and inter-patients variability of stored Pressures for the whole included population Intra- and inter-patients variability of stored Pressures for the whole included population;   Intra- and inter-patients variability of stored Pressures for subpopulations
15 Not yet recruiting Neurosurgery Recruitment Maneuver Study
Condition: Subdural Pressure During Supratentorial Brain Tumour Resection
Interventions: Procedure: Recruitment maneuver;   Procedure: Sham recruitment maneuver
Outcome Measures: Subdural Pressure;   Brain relaxation score;   Cerebral perfusion Pressure
16 Not yet recruiting Comparison of Low Versus Normal Pressure Pneumoperitoneum - With Profound Low Versus Normal Pressure Pneumoperitoneum -With Profound Muscle Relaxation- During Laparoscopic Donor Nephrectomy
Condition: Renal Disease
Interventions: Procedure: Low Pressure pneumoperitoneum;   Procedure: Normal Pressure pneumoperitoneum (12 mmHg);   Procedure: Deep neuromuscular block
Outcome Measures: Quality-of-Recovery 40 scale;   Cumulative use of opioids;   Cumulative use of other analgetics;   Post-operative complications;   Time to reach discharge criteria
17 Not yet recruiting Nocturnal Blood Pressure and Hypertension - Central and Peripheral 24-h Blood Pressure.
Conditions: Hypertension;   Chronic Kidneys Disease;   Obstructive Sleep Apnea
Intervention:
Outcome Measures: decrease in central systolic blood Pressure at night;   difference i blood Pressure levels throughout the day;   The correlation between the decrease in nighttime BP on one side and severity of OSA and BP in the daytime on the other.;   u-AQP2 and u-ENac;   PRC, p-AngII, p-aldosterone, p-AVP, p-endothelin
18 Unknown  Effect of Continuous Positive Airway Pressure for Treatment of Obstructive Sleep Apnea on Resistant Hypertension
Conditions: Resistant Hypertension;   Obstructive Sleep Apnea
Intervention: Device: continuous positive airway Pressure
Outcome Measures: mean systolic blood Pressure;   mean arterial blood Pressure;   mean diastolic blood Pressure;   high sensitivity C-reactive protein
19 Not yet recruiting Effect of Intrathoracic Pressure Regulation on Decreased Cerebral Perfusion
Conditions: Head Injury;   Intracranial Pathology;   Compromised Cerebral Perfusion
Intervention: Device: ITPR
Outcome Measures: Cerebral Perfusion Pressure (CPP);   systolic blood Pressure (SBP);   Arterial blood gases;   Diastolic blood Pressure (DBP);   Mean arterial Pressure (MAP);   Heart rate (HR);   Pulse Pressure (PP);   End-tidal carbon dioxide (EtCO2);   Oxygen saturation (SpO2)
20 Recruiting Clinical Value of Noninvasive Intracranial Pressure Measurement
Condition: Intracranial Hypertension
Interventions: Device: Noninvasive intracranial Pressure measurement;   Device: Brain MRI/CT;   Procedure: Lumbar puncture and cerebrospinal fluid Pressure measurement
Outcome Measure: Number of participants with the results of noninvasive intracranial Pressure measurement within clinically acceptable 4 mm Hg difference from CSF Pressure.

These studies may lead to new treatments and are adding insight into ESSURE etiology and treatment.

A major focus of ESSURE research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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