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Exforge Medical Research Studies

Up-to-date List of Exforge Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Exforge Medical Research Studies

Rank Status Study
1 Not yet recruiting A Phase I Clinical Trial to Investigate the Pharmacokinetic Interactions and Safety Between Exforge Tab. and Crestor Tab. in Healthy Male Subjects
Condition: Healthy
Intervention: Drug: administration of Exforge 10/160mg for 3days. Next 7days administration of Exforge 10/160mg and crestor 20mg.
Outcome Measures: Assessment of the drug-drug interactions of amlodipine, valsartan and rosuvastatin: Cmax,ss(Maximum steady-state plasma drug concentration during a dosage interval ), AUCτ(Area Under the Curve);   Assessment of the amlodipine, valsartan and rosuvastatin : AUCinf, tmax,ss(Time to reach Cmax,ss), t1/2
2 Recruiting Clinical Trial to Assess the Pharmacokinetic Characteristics of Lodivixx Tab. 5/160mg in Healthy Male Subjects (N=60)
Condition: Healthy Male Subjects
Interventions: Drug: Exforge tab. 10/160mg;   Drug: Lodivixx tab. 5/160mg
Outcome Measures: Cmax (maximum concentration);   AUC(area under curve);   Number of participants with adverse events
3 Unknown  Clinical Trial to Evaluate the Bioavailability and Safety of AGSAV301
Condition: Hypertension
Interventions: Drug: AGSAV301;   Drug: Exforge 10/160
Outcome Measures: Area Under Curve (AUC);   Cmax;   AUC (inf);   tmax;   t(1/2β)
4 Unknown  Valsartan and Amlodipine Compared to Losartan and Amlodipine in Hypertensive Patients
Condition: Essential Hypertension
Interventions: Drug: valsartan/amlodpine;   Drug: losartan/amlodpine
Outcome Measures: 24 hours mean, determinated through ABPM; diastolic mean after 4 weeks of losartan 100mg/amlodipine 5mg and valsartan 160mg/amlodipine 5mg treatment;   24 hours systolic mean, determinated through ABPM; day systolic and diastolic mean determinated through ABPM; night systolic and diastolic mean determinated through ABPM
5 Recruiting Study of Efficacy and Safety of CVAA489 in Hypertensive Patients
Condition: Essential Hypertension
Intervention: Drug: amlodipine/valsartan
Outcome Measures: Percentage of patients with control rate of blood pressure (BP);   Change from baseline in systolic blood pressure (SBP) in patients treated with valsartan/amlodipine at 2 months;   Change from baseline in diastolic blood pressure (DBP) in patients treated with valsartan/amlodipine at 2 months;   Change from baseline control rate of BP in patients with high sodium intake at 2 months;   Change from baseline in SBP and DBP in patients with high sodium intake;   Number of patients with total adverse events, serious adverse events and death to assess tolerability of valsartan/amlodipine
6 Not yet recruiting Pharmacokinetic Interactions Between Amlodipine Besylate/Valsartan and Atorvastatin in Healthy Male Subjects
Condition: Healthy
Intervention: Drug: combination administration
Outcome Measures: To Evaluate PK interaction of amlodipine and valsartan;   To Evaluate PK interaction of atorvastatin and 2-OH atorvastatin

These studies may lead to new treatments and are adding insight into Exforge etiology and treatment.

A major focus of Exforge research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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