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False Positive Laboratory Result Medical Research Studies

Up-to-date List of False Positive Laboratory Result Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest False Positive Laboratory Result Medical Research Studies

Rank Status Study
1 Unknown  Randomized Controlled Trial on Visual Field Training
Condition: Glaucoma
Intervention: Other: Practice program
Outcome Measures: The absolute value of the difference in mean deviation of the first and second visual field exam;   Difference in the absolute number of altered points in the visual field with a total deviation below the 0.5 percentile;   Difference in the percentage of false positives, false negatives, and fixation losses at the first and second exam between control and intervention group;   Difference in the time required to complete the first and second exam;   Difference in the proportion of unreliable visual fields at the first and second exam between control and intervention groups
2 Unknown  Clinical Relevance of Anti-Neutrophil Cytoplasm Antibody (ANCA)in Hospitalized Patients
Condition: ANCA-related Vasculitis
Intervention: Other: Interpretation of blood test results
Outcome Measure: Mostly negative lab results
3 Recruiting Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome?
Conditions: Cushing's Syndrome;   Adrenal Incidentalomas;   Alcoholism;   Obesity
Intervention:
Outcome Measures: The difference (in percent) in false positive DXM-tests comparing the outcome of all tests with all tests excluding those with s-DXM below the the cut-off specified below.;   Calculate the positive likelihood ratio [(1-sensitivity)/specificity] for the short DXM-test in the assessment of Cushing's syndrome (CS), after excluding those with s-DXM below the DXM cut-off specified in the primary endpoint.;   Calculate the negative likelihood ratio [(1-sensitivity)/specificity] for the short DXM-test in the assessment of Cushing's syndrome, after excluding those with s-DXM below the DXM cut-off specified in the primary endpoint.;   Calculate the positive likelihood ratio [(1-sensitivity)/specificity] for midnight salivary cortisol in the assessment of Cushing's syndrome. All study cases are included in this analysis.;   Calculate the negative likelihood ratio [(1-sensitivity)/specificity] for midnight salivary cortisol in the assessment of Cushing's syndrome. All study cases are included in this analysis.;   Calculate the positive likelihood ratio [(1-sensitivity)/specificity] for midnight salivary cortisone in the assessment of Cushing's syndrome. All study cases are included in this analysis.;   Calculate the negative likelihood ratio [(1-sensitivity)/specificity] for midnight salivary cortisone in the assessment of Cushing's syndrome. All study cases are included in this analysis.;   Identical to primary endpoint, but saliva-DXM measurements replace serum-DXM.;   Identical to primary endpoint, but saliva-DXM measurements replace serum-DXM, and saliva-cortisol replace serum-cortisol.;   Identical to primary endpoint, but saliva-DXM measurements replace serum-DXM and saliva-cortisone replace serum-cortisol.;   Calculate the positive likelihood ratio [(1-sensitivity)/specificity] for creatinine-adjusted cortisol in morning spot urine in the assessment of Cushing's syndrome. All study cases are included in this analysis.;   Calculate the negative likelihood ratio [(1-sensitivity)/specificity] for creatinine-adjusted cortisol in morning spot urine in the assessment of Cushing's syndrome. All study cases are included in this analysis.;   Compute a 95% confidence interval for morning s-DXM following overnight DXM-test in healthy subjects using parametric and non-parametric statistics.;   Quantitatively and qualitatively describe the characteristics of patients with false positive DXM-test and true negative DXM-test based on a standard questionnaire scoring patient history, symptoms and clinical features.;   Evaluate the dexamethasone metabolism in patients with obesity;   Evaluate the dexamethasone metabolism in patients with alcohol abuse
4 Recruiting Low vs. Standard Dose CT for Appendicitis Trial
Condition: Appendicitis
Interventions: Radiation: Diagnostic CT with low-dose radiation;   Radiation: Diagnostic CT with standard-dose radiation
Outcome Measures: Negative appendectomy rate;   Appendiceal perforation rate;   Additional Imaging Test(s);   Delay in patient disposition;   Hospital stay associated with non-incidental appendectomy;   Diagnostic performance of CT reports;   Diagnostic confidence in diagnosing and ruling out appendicitis;   Diagnosis of appendiceal perforation at CT
5 Recruiting HPV E6/E7 mRNA Versus HPV DNA as Triage for Cervical Cancer Screening
Conditions: CIN;   Cervix Cancer
Intervention:
Outcome Measure: Efficacy Outcome Measure
6 Recruiting High Risk Multiple Gestation Study
Conditions: Trisomy 13;   Trisomy 18;   Trisomy 21;   Sex Chromosome Abnormalities
Intervention:
Outcome Measure: Screening capability of NATUS algorithm in the form of a risk results classified as positive result for aneuploidy, negative result for aneuploidy or 'no call.'
7 Recruiting Multiple Gestation Study
Conditions: Trisomy 13;   Trisomy 18;   Trisomy 21;   Sex Chromosome Abnormalities
Intervention:
Outcome Measure: The primary outcome will be to confirm the diagnostic capability of NATUS risk results classified as positive result for aneuploidy, negative result for aneuploidy or 'no call.'
8 Not yet recruiting Generalized Neonatal Screening of Severe Combined Immunodeficiencies
Condition: Severe Combined Immunodeficiency, Atypical
Intervention: Biological: SCID screening
Outcome Measures: cost / efficiency ratio of the implementation of the generalized neonatal screening of SCID at birth;   Cost / efficiency ratio of the implementation of the generalized neonatal screening of SCID at birth;   The cost of care during the first 18 months of life per child enjoying an early curative treatment in the first 4 months of life.;   Length of hospitalization of children with SCID in the first 18 months of life;   number of avoided deaths;   number of detected SCID patients;   number of patients detected with other T lymphopenia (SCID variants , DiGeorge , severe T lymphopenia non SCID ... );   number of false negative and false positive results
9 Recruiting Determination of HCV Prevalence in a HIV Patient Cohort in Phnom Penh, Cambodia
Conditions: Hepatitis C;   HIV
Intervention: Procedure: HCV screening
Outcome Measures: Seroprevalence of HCV infection;   Proportion of current HCV infection;   Proportion of HCV false-positives;   HCV genotypes;   Severity of liver disease in HCV patients;   HCV diagnostic accuracy
10 Recruiting LOUIS-3D Breast Study
Condition: Breast Cancer
Intervention: Procedure: LOUIS-3D Imaging Procedure
Outcome Measures: LOUIS 3D Capability to Detect and Differentiate Breast Tumors;   Comparison of False Positive Rate of LOUIS-3D Compared to Ultrasound for Breast Cancer Detection
11 Unknown  Performance Proof of the New NORMA-SENSE
Condition: Vaginal Infection
Intervention: Device: NORMA-SENSE
Outcome Measure: We will asses agreement between the color status of the NORMA-SENSE as reported by the subject after using the panty liner, and the pH measurement with Nitrazine paper.
12 Not yet recruiting FAST MRI Study in Breast Cancer Survivors
Condition: Breast Cancer
Intervention: Other: FAST MRI and mammography screening
Outcome Measures: The percentage of patients with reduced anxiety as a result of having a FAST MRI;   Numbers of recurrent tumors in each arm
13 Unknown  The Effect of PPI Therapy on the Result of Helicobacter Pylori Diagnostic Tests
Condition: Helicobacter Pylori
Intervention:
Outcome Measure: Effect of PPI treatment on helicobacter pylori diagnostic tests
14 Recruiting Non Invasive Prenatal Diagnosis of Trisomy 21 by Genetic Analysis of Circulating Fetal Cells
Condition: Trisomy 21
Intervention: Other: sample blood
Outcome Measure: non-invasive method of PND of Trisomy 21.
15 Not yet recruiting Blood Test for Breast Cancer Associated Auto Antibodies - Improvement of Octava Blood Test
Condition: Breast Cancer
Intervention:
Outcome Measure: Number of participants in each of the clinicaly defined groups (0,1 and 2).
16 Unknown  A Pilot Study for the Use of Biomarkers and Early Treatment of Invasive Candidiasis in Intensive Care Unit (ICU) Patients
Condition: Candidemia
Intervention: Drug: Anidulafungin
Outcome Measure: Exploratory analysis of the kinetics of 1,3 beta-D-glucan in hig-risk patients
17 Recruiting D-dimer and Pre-test Clinical Probability Score in Cancer Patients With Suspected Deep Vein Thrombosis of the Legs
Condition: Deep Vein Thrombosis
Intervention: Other: Diagnostic tests for suspected deep vein thrombosis
Outcome Measures: Proportion of false negative results of the combination of the modified Wells score and D-dimer results;   Sensibility, specificity, positive and negative predictive values of the modified Wells score and D-dimer
18 Recruiting Age-adjusted D-dimer Cut-off Levels to Rule Out Pulmonary Embolism
Condition: Pulmonary Embolism
Intervention: Other: Evaluation of a modified DD cut-off to rule out PE
Outcome Measures: The main outcome is the rate of thromboembolic events during a formal 3-month follow-up in patients not anticoagulated on the basis of a PE ruled out by the association mentioned here above.;   Prospective validation of the simplified revised Geneva score.
19 Recruiting Combined Digital Colposcopy Analysis to Improve Cervical Precancer and Cancer Detection
Conditions: Cervical Cancer;   Precancerous Condition
Intervention: Device: Multispectral Digital Colposcope (MDC)
Outcome Measure: Detection of cancer or pre-cancerous abnormalities of the cervix by multispectral digital colposcope.
20 Recruiting Swiss Austrian German Testicular Cancer Cohort Study - SAG TCCS
Condition: Testicular Neoplasms
Intervention:
Outcome Measures: Mode of relapse detection;   Rate of relapses detected on chest x-ray in seminoma patients;   Rate of false positive abnormalities on CT scan;   Rate of false positive tumour marker elevations not due to seminomatous or non-seminomatous germ cell tumour relapses but due to other reasons;   Patient characteristics at baseline and at the time-point of relapse detection.;   Rate of stage I seminoma and non-seminoma patients undergoing active surveillance.;   Overview of treatment and follow-up strategies in germ cell cancer patients in Switzerland, Austria and Germany;   Treatment sequelae following testicular cancer treatment in terms of organ function, cardiovascular risk factors, sexual health and socioeconomic aspects.;   Rate of intermediate and poor-prognosis disease at relapse.;   Rate of offspring spontaneously conceived after testicular cancer treatment.

These studies may lead to new treatments and are adding insight into False Positive Laboratory Result etiology and treatment.

A major focus of False Positive Laboratory Result research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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