Up-to-date List of Fanapt Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Fanapt Medical Research Studies

1 Recruiting Assessing the Effects of Fanapt® on Social Cognition in Schizophrenia
Conditions: Schizophrenia;   Schizoaffective Disorder
Intervention: Drug: Iloperidone
Outcome Measure: Change in Social Cognition at 12 Weeks
2 Recruiting Iloperidone for Symptoms of Arousal in Post Traumatic Stress Disorder (PTSD)
Condition: Post Traumatic Stress Disorder
Interventions: Drug: Iloperidone;   Drug: Placebo
Outcome Measures: Change in Clinician Administered PTSD Scale (CAPS) Part B and D score;   Sleep;   Agitation;   Aggression;   Suicidal ideation and behavior
3 Recruiting Tolerability and Pharmacokinetics of Iloperidone in Adolescent Patients
Condition: Safety and Tolerability of Iloperidone
Intervention: Drug: iloperidone (oral tablet)
Outcome Measures: Pharmacokinetics of iloperidone at different dose levels based on AUC (area under the plasma concentration time curve during a dosage interval) Cmax ss (maximum plasma concentration at steady state), Tmax ss (time to Cmax at steady state).;   Tolerability of iloperidone at different dose levels;   Number of Patients with Adverse Events, Serious Adverse Events or Death;   Change from baseline in Clinical Global Impression of Improvement Scale (CGI-I);   Change from baseline in the Children's Global Asessment Scale (CGAS;   Effect of iloperidone on QT, QT beat-to-beat (QTbtb), QT corrected using the Fridericia formulat (QTcF), QT corrected using the Bazett formula (QTcB), individual based correct QT (QTcI);   Clinically notable changes from baseline on electrocardiogram (ECG) parameters (QTcF, QTcB, QRS, PR, heart rate)
4 Recruiting Assessment and Comparison of Metabolic Changes in Non-psychotic Adults Taking Iloperidone or Olanzapine or Placebo
Condition: Healthy
Interventions: Drug: olanzapine;   Drug: iloperidone
Outcome Measures: Association between initial change in leptin level and 6-week weight change;   change in leptin
5 Recruiting Relapse Prevention Study in Patients With Schizophrenia
Condition: Schizophrenia
Interventions: Drug: Iloperidone;   Drug: Placebo
Outcome Measures: To determine the efficacy of flexible dosing of iloperidone compared with placebo in relapse prevention with evaluation of patients by psychiatric rating scales.;   To explore the long-term safety and tolerability of flexible dosing of iloperidone (8, 12, 16, 20, or 24 mg/day given bid);   To explore the long-term efficacy of flexible dosing of iloperidone (8, 12, 16, 20, or 24 mg/day given bid) as measured by psychiatric rating scales.;   To explore the long-term safety and tolerability of flexible dosing of iloperidone (8-24 mg/day) over an additional optional 52 weeks of treatment (open-label extension phase).
6 Recruiting Iloperidone Augmentation of SSRIs for Patients With Major Depressive Disorder With Residual Anger and Irritability
Condition: Major Depressive Disorder
Interventions: Drug: Iloperidone;   Drug: Placebo
Outcome Measures: Total score on Anger/Hostility scale of the Symptom Questionnaire;   Adverse Events
7 Recruiting Cross-Sectional Iloperidone IVGTT
Conditions: Schizophrenia;   Serious Mental Illness;   Metabolic Syndrome;   Insulin Resistance;   Glucose Metabolism
Outcome Measures: Difference between cohorts in glucose metabolism;   Difference between cohorts in triglycerides;   Difference between cohorts on LDL cholesterol

These studies may lead to new treatments and are adding insight into Fanapt etiology and treatment.

A major focus of Fanapt research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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