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Feeling Abnormal Medical Research Studies

Up-to-date List of Feeling Abnormal Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Feeling Abnormal Medical Research Studies

Rank Status Study
1 Recruiting Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders
Condition: Smoking Cessation
Interventions: Drug: Placebo;   Drug: varenicline tartrate;   Drug: bupropion hydrochloride;   Drug: Nicotine Replacement Therapy Patch
Outcome Measures: At least 1 severe AE of anxiety depression, Feeling Abnormal, or hostility and/or moderate or severe AE of: agitation, aggression, delusions, hallucinations, homicidal ideation, mania, panic, paranoia, psychosis, suicidal ideation/behavior/completed;   4 week Carbon Monoxide (CO) confirmed continuous abstinence for Weeks 9 through 12.;   Carbon Monoxide (CO) confirmed continuous abstinence from Week 9 through Week 24;   The presence or absence of each component comprising the primary neuropsychiatric adverse event endpoint.;   Individual item responses and overall scores for Hospital Anxiety and Depression Scale;   Individual item responses and overall scores for Columbia Suicide Severity Rating Scale;   Individual item responses and overall scores for Global Clinical Impression of Improvement
2 Recruiting Developmental Outcomes of Extreme Prematurity: Correlations With Maternal Post-Traumatic Symptoms, Parental Stress and Post-Traumatic Growth, 5-15 Years Postpartum
Conditions: Preterm Infants;   Post Traumatic Stress Disorder;   Emotional Stress;   Infant, Very Low Birth Weight
Outcome Measure: Not relevant
3 Unknown  Preventing ICU Subsyndromal Delirium Conversion to Delirium With Haloperidol
Condition: Subsyndromal Delirium
Interventions: Drug: Haloperidol decanoate;   Drug: Placebo
Outcome Measures: Conversion from subsyndromal delirium to delirium during the period of study drug administration (up to 10 days).;   The number of hours spent agitated (SAS >/=5) as percent of time study drug administered (up to 10 days).;   Duration of mechanical ventilation.;   Clinically significant QTc interval prolongation (≥ 500 msec or an increase of more than 60msec above baseline);   Extrapyramidal effects (as evidenced by a positive Simpson-Angus Scale Score);   The number of hours spent excessively sedated (SAS ≤ 2) as a percent of time study drug administered (up to 10 days).;   Cognition, incidence of anxiety, incidence of depressive symptoms, quality of life (ie., functional status and emotional well being)and sleep quality.
4 Unknown  Lamotrigine Monotherapy in Pediatric Bipolar Disorder
Condition: Bipolar Disorder
Intervention: Drug: Lamotrigine
Outcome Measures: Young Mania Rating Scale (YMRS),;   Bipolar Clinical Global Impression Scale (BP-CGI),;   Overt Aggression Scale (OAS),;   Child Depression Rating Scale-Revised (CDRS-R),;   Brief Psychiatric Rating Scale in Children (BPRS-C),;   Child Bipolar Rating Scale- Parent version (subscales: Child Mania Rating Scale,;   Child Bipolar Depression Rating Scale,;   Child Bipolar Cycling Rating Scale) and Teacher version (subscales: Child Mania Rating Scale,;   Child Bipolar Depression Rating Scale)(CBRS-P/T),;   Abnormal Involuntary Movements Scale (AIMS),;   Pediatric Side Effects Rating Scale (P-SERS),;   CAFAS (Child and Adolescent Functional Assessment Scale)
5 Recruiting Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study
Condition: Phantom Limb Pain
Intervention: Drug: Perineural infusion [continuous peripheral nerve block(s)]
Outcome Measures: Phantom limb pain intensity 4 weeks following initiation of an ambulatory CPNB (as measured by the Numeric Rating Scale within the Brief Pain Inventory).;   Perception of well-being 4 weeks following an ambulatory CPNB (as measured with the Patient Global Impression of Change Scale).;   Physical and emotional functioning 4 weeks following initiation of an ambulatory CPNB (as measured with the Brief Pain Inventory).;   Depression 4 weeks following initiation of an ambulatory CPNB (as measured with the Beck Depression Inventory).
6 Recruiting Understanding Decision Making Processes for Undergoing Genetic Testing Among Women With Newly Diagnosed Breast Cancer
Condition: Breast Cancer
Intervention: Genetic: BRCA testing and questionnaire assessments
Outcome Measures: To determine the relative proportions of women offered genetic testing after a breast cancer diagnosis who decide to have BRCA testing;   To determine the relative proportions of women who decide to undergo prophylactic mastectomy (PM);   To assess the factors associated with the decision to choose pre- or post surgical testing.;   To assess regret experienced by women choosing to undergo either pre- or post-surgical testing.;   To delineate factors associated with regret about the timing of genetic testing
7 Unknown  Irritable Bowel Syndrome (IBS) Functional Magnetic Resonance Imaging (fMRI) With Desipramine
Condition: Irritable Bowel Syndrome
Intervention: Drug: Desipramine
Outcome Measure: Changes in brain activations using functional MR following desipramine therapy in IBS populations.
8 Recruiting Light Sedation or Intubated General Anesthesia in Patients With Brain Cancer Undergoing Craniotomy
Condition: Adult Brain Tumor
Interventions: Procedure: Arm I (light sedation);   Procedure: Arm II (intubated general anesthesia);   Other: Arm II (intubated general anesthesia);   Other: Arm I (light sedation)
Outcome Measures: Compare overall hospital length of stay for patients in each of 2 arms;   Compare resource utilization between two groups;   Assess the frequency of post-operative delirium;   Measure patient perceptions;   Track patient complications during hospital stay;   Track re-admission and extended hospital stay rates
9 Recruiting Study of Proteus Syndrome and Related Congenital Disorders
Conditions: Growth Disorder;   Mental Retardation;   Multiple Abnormalies
Outcome Measure:
10 Unknown  Cohort Study: Perceptual Urge Sensation
Conditions: Urinary Bladder, Overactive;   Osteoporosis
Interventions: Other: Micturition diary;   Other: Hospital Anxiety and Depression scale;   Other: EuroQol-5D;   Other: Self-consciousness questionnaire
Outcome Measures: Defining differences in self-consciousness and HADS scores in patients with OAB;   Defining differences between self-consciousness and HADS scores between the two cohorts;   Defining differences in quality of life between the two cohorts
11 Recruiting Opioid System Cerebral Activity in Endurance Sportswomen - Addiction or Denutrition ? [11C]Diprenorphine PET Study
Condition: Sports Nutritional Sciences
Intervention: Other: [11C]diprenorphine
Outcome Measures: [11C]diprenorphine binding potential;   correlation [11C]diprenorphine BP
12 Not yet recruiting Early Elimination of Premature Ventricular Contractions in Heart Failure
Conditions: Premature Ventricular Contractions;   Congestive Heart Failure
Intervention: Device: PVC ablation
Outcome Measures: change of left ventricular ejection fraction measured with Simpson's rule expressed in percent from pre to post intervention;   Change of echocardiographic Parameters;   Change in serum biomarker level;   Change in Heart Failure Symptoms
13 Recruiting The Effects of Repetitive Paired Associative Stimulation in Dystonia
Condition: Dystonia
Outcome Measure: Change from baseline in the motor evoked potential (MEP) amplitude at S50 after 30 minutes from rPAS (T30).
14 Recruiting Depotentiation in People With Focal Hand Dystonia
Conditions: Focal Dystonia;   Healthy Volunteers
Outcome Measure: Motor evoked potential amplitude
15 Recruiting Fat Grafting for Pedal Fat Pad Atrophy in Diabetics
Conditions: Pedal Pad Atrophy;   Diabetes Mellitus
Interventions: Procedure: Year A Pathway;   Procedure: Year B Pathway
Outcome Measures: Durability of Relief and reduction of foot pressure;   Measurement of pedal pressure and plantar tissue thickness;   Measurement of durability of fat grafting vs silicone or other fillers;   Assessment of pain and skin lesions
16 Recruiting Surgery as a Treatment for Medically Intractable Epilepsy
Conditions: Epilepsy;   Epilepsy, Temporal Lobe;   Partial Epilepsy
Intervention: Procedure: Surgery
Outcome Measures: Change in seizure frequency, as measured by the Engel scale before and one year after treatment;   Percentage seizure-free;   Mean Engel Class one year after surgery;   Percentage with permanent neurological side-effects from surgical treatment;   Incidence of serious complications of epileptic seizures
17 Recruiting Vibratory Therapy for Patients With Chronic Low Back Pain
Condition: Low Back Pain
Intervention: Other: Exercises
Outcome Measures: Electromyographic analysis of the trunk erector of patients with chronic low back pain .;   Analysis of pain using a visual analogue scale .

These studies may lead to new treatments and are adding insight into Feeling Abnormal etiology and treatment.

A major focus of Feeling Abnormal research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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