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Feridex Medical Research Studies

Up-to-date List of Feridex Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Feridex Medical Research Studies

Rank Status Study
1 Unknown  Comparative Evaluation of Various Combinable Magnetic Resonance (CMR) Pulse-sequences for Macrophage Imaging Using Ferucarbotran
Condition: Acute Myocardial Infarction
Intervention: Drug: Ferucarbotran (Resovist)
Outcome Measure: Extent of myocardial infarction (as demonstrated with gadolinium-based necrosis/ fibrosis imaging compared to macrophage imaging using ferucarbotran)
2 Unknown  Cell Tracking Using Superparamagnetic Particles of Iron Oxide (SPIO) and Magnetic Resonance Imaging (MRI) - A Pilot Study
Condition: Healthy Volunteer
Interventions: Biological: Administration of autologous Endorem-labelled mononuclear cells intravenously;   Drug: Administration of Endorem
Outcome Measure: Change in signal intensity in the region of interest on MRI scanning
3 Recruiting Pre-Operative Nodal Staging of Thyroid Cancer Using Ultra-Small Superparamagnetic Iron Oxide Magnetic Resonance Imaging (USPIO MRI): Preliminary Study
Conditions: Papillary Carcinoma of Thyroid Metastatic to Regional Lymph Node;   Metastatic Medullary Thyroid Cancer;   Follicular Thyroid Cancer Lymph Node Metastasis
Interventions: Drug: Ferumoxytol;   Device: lymphotrophic superparamagnetic nanoparticles (LSN MRI).
Outcome Measures: Primary efficacy parameters of ensitivity and specificity of high resolution magnetic resonance imaging with lymphotrophic superparamagnetic nanoparticles (LSN MRI);   Identification of small and otherwise undetectable lymph node metastases in patients with primary or recurrent papillary or medullary thyroid cancer who are scheduled for surgical resection.;   Assess the presence of histologically positive lymph nodes outside of the usual field of surgical resection.
4 Unknown  Inflammatory Cell Trafficking After Myocardial Infarction
Conditions: Myocardial Infarction;   Inflammation
Interventions: Other: Infusion of investigational product;   Other: Cardiac magnetic resonance imaging
Outcome Measures: Change in cardiac MRI signal intensity from baseline after administration of labelled vs. unlabelled mononuclear cells.;   Correlation of myocardial MRI signal intensity change from baseline with markers of systemic inflammation.
5 Unknown  Islet of Langerhans Graft Monitoring by Magnetic Resonance Imaging
Condition: Type 1 Diabetes Mellitus
Interventions: Drug: ferucarbotran (iron-based MRI contrast agent);   Procedure: Islet transplantation;   Procedure: Magnetic resonance imaging
Outcome Measures: Semi-quantitative assessment of intrahepatic MRI signal on T2*-weighted sequences, at 6 days, 6 weeks, 6 months and 1 year after transplantation;   Islet graft function assessed by exogenous insulin requirements, HbA1c, mean amplitude of glucose excursions (MAGE) and fasting C-peptide.
6 Recruiting Ferumoxytol - Iron Oxide Nanoparticle Magnetic Resonance Dynamic Contrast Enhanced MRI
Condition: Head and Neck Cancer
Interventions: Procedure: Magnetic Resonance Imaging (MRI);   Drug: Ferumoxytol
Outcome Measure: Feasibility of Using Ferumoxytol with Magnetic Resonance Imaging (MRI)
7 Recruiting High-Field MRI Iron-Based Contrast-Enhanced Characterization of Multiple Sclerosis and Demyelinating Diseases
Condition: Multiple Sclerosis
Interventions: Drug: Feraheme;   Drug: Gadolinium-based contrast
Outcome Measures: Number and location of enhancing brain lesions seen on 7 tesla MRI following Feraheme administration.;   Number and location of enhancing brain lesions seen on 7 tesla MRI following gadolinium-based contrast administration.
8 Unknown  Cliavist in Infectious and Degenerative Diseases of the Spine
Condition: Spine Infection
Intervention: Drug: Cliavist
Outcome Measures: First MRI: performed immediately after gadolinium administration;   Second MRI: performed 24 hours after cliavist administration

These studies may lead to new treatments and are adding insight into Feridex etiology and treatment.

A major focus of Feridex research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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