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Fibrillation Medical Research Studies

Up-to-date List of Fibrillation Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Fibrillation Medical Research Studies

Rank Status Study
1 Recruiting FIRM as a Stand-alone Procedure in the Treatment of Atrial Fibrillation
Condition: Atrial Fibrillation
Intervention: Procedure: FIRM ablation
Outcome Measures: Single procedure freedom from atrial Fibrillation (AF) at 12 months.;   Single procedure freedom from atrial Fibrillation (AF) at 24 months.;   Single procedure freedom from atrial Fibrillation (AF) at 30 months.
2 Recruiting Focal Impulse and Rotor Modulation Ablation Trial for Treatment of Paroxysmal Atrial Fibrillation (FIRMAT-PAF)
Condition: Paroxysmal Atrial Fibrillation
Interventions: Procedure: PVI Ablation;   Procedure: FIRM Ablation
Outcome Measures: Acute Ablation Success for Paroxysmal Atrial Fibrillation;   Long Term Ablation Success for Paroxysmal Atrial Fibrillation
3 Recruiting Reduction of Fluoroscopy Exposure During Atrial Fibrillation Ablation
Condition: Atrial Fibrillation
Intervention: Device: Radio-frequency catheter ablation
Outcome Measures: Fluoroscopy time for each step of atrial Fibrillation ablation procedure;   Fluoroscopy doses for each step of atrial Fibrillation ablation procedure;   Number of patients with adverse events as a measure of safety;   Number of patients with a failure of reaching endpoints of procedure as a measure of efficacy;   Total time of atrial Fibrillation ablation procedure as a measure of efficacy
4 Unknown  Atrial Fibrillation Ablation The Hybrid Approach Versus Traditional Management
Condition: Ablation of Atrial Fibrillation
Interventions: Procedure: Pulmonary vein isolation ablation procedure for atrial Fibrillation;   Procedure: Hybrid procedure for ablation of atrial Fibrillation;   Procedure: The Cox Maze Procedure for Ablation of Atrial Fibrillation;   Procedure: Hybrid Procedure for Left Atrium >5 cm but < 6.1 cm
Outcome Measures: Return to sinus rhythm rate;   Post procedure morbidities
5 Recruiting Manual vs Amigo SmartTouch Atrial Fibrillation Study
Condition: Atrial Fibrillation
Interventions: Procedure: Catheter ablation for atrial Fibrillation, manual;   Device: Ablation using Amigo remote catheter system
Outcome Measures: Contact force delivered;   Quantity and contiguity of ablation lesions;   Recurrence of atrial Fibrillation
6 Recruiting Atrial Fibrillation Progression Trial
Condition: Atrial Fibrillation
Interventions: Device: Left Atrial Ablation (Carto® 3, Carto® XP System, or Carto® RMT and ThermoCool®);   Drug: Rate or Rhythm Control Therapy
Outcome Measures: Time to persistent atrial Fibrillation/atrial tachycardia excluding isthmus-dependent atrial flutter;   Rate and time to persistent AF/AT;   Rate of persistent AF/AT by number of ablations;   Number of repeat ablations and new antiarrhythmic drugs;   Rhythm (% subjects in Sinus Rhythm, % subjects with recurrent atrial Fibrillation);   Subject's pre-existing or new onset/worsened condition(s), that may be associated with progression of atrial Fibrillation;   Catheter-related complications (ablation); adverse drug reactions (AAD);   Health care utilization (number and length of hospitalizations and unscheduled cardiovascular-related visits);   Quality of Life
7 Recruiting Know Your Pulse Post Stroke-Measurement of Peripheral Pulse for Detection of Atrial Fibrillation After Ischemic Stroke
Conditions: Stroke;   Atrial Fibrillation
Interventions: Behavioral: Measurement of peripheral pulse;   Device: 72h holter ECG
Outcome Measures: Number of newly detected cases of atrial Fibrillation;   Comparison of detection rates by MPP and by serial holter ECG (3 months, 6 months);   Timepoint of detection of atrial Fibrillation by MPP or holter ECG;   Modification of secondary preventive medication by detection of atrial Fibrillation;   Recurrent stroke and mortality
8 Recruiting Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II)
Condition: Atrial Fibrillation
Intervention: Other: Patients with Atrial Fibrillation
Outcome Measures: Number of major bleeding events;   Number of major adverse cardiac events
9 Recruiting Atrial Fibrillation After Cardiac Surgery-comparing Conventional and Miniaturized Bypass Systems
Condition: Atrial Fibrillation
Intervention: Procedure: Miniaturized bypass system
Outcome Measure: Atrial Fibrillation
10 Recruiting Reasons for Variations in Health Related Quality of Life and Symptom Burden in Patients With Atrial Fibrillation
Conditions: Arrhythmias, Cardiac;   Heart Failure, Systolic;   Atrial Fibrillation
Intervention:
Outcome Measures: Symptom burden vs. peptide markers for heart failure;   Sub-study primary outcome: Levels of four biomarkers in relation to heart rhythm;   Levels of NT-proBNP and MR-proANP in different sites of the heart and the effect of radiofrequency ablation in relation to heart rhythm;   Levels of copeptin and MR-proADM in different sites of the heart and the effect of radiofrequency ablation;   The relation between left atrial function and neurohormonal activation in patients with atrial Fibrillation eligible for radio frequency ablation;   The effect of radiofrequency ablation on the left atrial and left atrial appendix function;   Alcohol consumption in a atrial Fibrillation population undergoing radio frequency ablation (RFA), the connection between alcohol consumption and quality of life and arrhythmia freedom after RFA;   Which factors influence the quality of life in patients with atrial Fibrillation (AF) undergoing ablation. Do patients with more symptoms have a greater activation of neurohormonal systems and increase of intracardiac pressures after the initiation of AF
11 Recruiting CatHeter Ablation of perSistEnd Atrial Fibrillation: Pulmonary Vein Isolation Versus Defragmentation. The CHASE-AF Study
Conditions: Atrial Fibrillation;   Catheter Ablation;   Persistent Atrial Fibrillation;   Pulmonary Vein Isolation
Intervention: Procedure: Atrial Fibrillation ablation
Outcome Measures: Recurrence of atrial arrhythmia during 12 months follow up;   Number of periprocedural complications
12 Recruiting Effect of 3 Years of Exercise in Patients With Atrial Fibrillation
Condition: Atrial Fibrillation
Interventions: Behavioral: Interval exercise;   Behavioral: Moderate exercise;   Behavioral: Control
Outcome Measures: Change in burden of atrial Fibrillation;   Size of left ventricle;   Quality of life;   Endothelial function;   Maximal oxygen uptake;   Atrial extrasystoles;   Number of hospitalisations with atrial Fibrillation as main diagnosis;   Total number of electrical cardioversions;   Size of left atrium;   Function of left atrium;   Function of left ventricle;   Symptom burden
13 Recruiting TOCCASTAR - TactiCath Contact Force Ablation Catheter Study for Atrial Fibrillation
Condition: Paroxysmal Atrial Fibrillation
Intervention: Device: Catheter ablation for the treatment of paroxysmal atrial Fibrillation
Outcome Measures: Freedom from recurrence of symptomatic atrial Fibrillation, atrial tachycardia or atrial flutter;   Incidence of device-related early-onset primary serious adverse events
14 Recruiting THE GIRAFFE Study: Genomic Risk Markers for Atrial Fibrillation Following Extended Cardiac Rhythm Monitoring
Condition: Patients With Symptoms of Cardiac Arrhythmia at Risk for Atrial Fibrillation
Intervention:
Outcome Measure: Association between events of Atrial Fibrillation and 4-SNP risk score
15 Recruiting Rhythm Control - Catheter Ablation With or Without Anti-arrhythmic Drug Control of Maintaining Sinus Rhythm Versus Rate Control With Medical Therapy and/or Atrio-ventricular Junction Ablation and Pacemaker Treatment for Atrial Fibrillation
Conditions: Heart Failure;   Atrial Fibrillation
Interventions: Procedure: Catheter ablation-based AF rhythm control;   Drug: Medication Rate Control
Outcome Measures: Composite of all-cause mortality and hospitalization for heart failure defined as an admission to a health care facility for > 24 hours.;   All-cause mortality, Cardiovascular Mortality, All-cause hospitalization, Heart Failure hospitalization, CV hospitalization, health related QoL, see description for more details
16 Recruiting The Dynamics of Human Atrial Fibrillation
Conditions: Atrial Fibrillation;   Atrial Tachyarrhythmia
Intervention:
Outcome Measures: Survival Free of Atrial Fibrillation;   Termination of atrial Fibrillation during ablation
17 Recruiting Graz Study on the Risk of Atrial Fibrillation
Conditions: Atrial Fibrillation;   Hypertension;   Diabetes;   Chronic Heart Failure;   Vascular Disease
Intervention: Device: Medtronic Reveal XT implantable loop recorder
Outcome Measures: Time to first diagnosis of atrial Fibrillation;   Time to change in therapy based on the diagnosis of atrial Fibrillation;   Hospitalizations;   Change in NTproBNP serum level associated with occurrence of atrial Fibrillation;   Death;   Stroke
18 Unknown  Cardioversion vs. Catheter Ablation for Persistent Atrial Fibrillation
Condition: Atrial Fibrillation
Interventions: Procedure: catheter ablation;   Procedure: external electric cardioversion
Outcome Measures: Event-free survival after 6 months (i.e. freedom of atrial tachyarrhythmias - as evaluated in a 7-d-holter, stroke, pulmonary vein stenosis - as evaluated in a CT-/MRT-scan 6 months after the initial procedure - and death).;   success-rate immediately after intervention;   need for re-intervention between 2 and 3 months after initial procedure if not stable sinus rhythm at the two-months follow-up (further ablation/cardioversion);   burden of atrial Fibrillation in a 7-day-holter after 6 months;   significant improvement in exercise capacity (measured by spiroergometry);   decrease in NT-pro-BNP levels in the blood after 6 months compared to the level before initial intervention;   improvement of quality-of-life (combined questionnaire including the SF-36 form) before initial intervention and at the 6-months follow-up
19 Recruiting Feasibility Testing of the Alert for Atrial Fibrillation Program
Condition: Atrial Fibrillation
Intervention: Behavioral: Alert for Atrial Fibrillation Program
Outcome Measure: Changes on the Knowledge, Attitudes, and Beliefs about Atrial Fibrillation Survey
20 Unknown  Atorvastatin Using as a Possible Prophylaxis of Postoperative Atrial Fibrillation After Cardiac Surgery
Condition: Atrial Fibrillation
Intervention: Procedure: Cardiac surgery
Outcome Measures: Number of patients with postoperative atrial Fibrillation(atorvastatin and control groups);   Changes in inflammatory markers values during extracorporeal circulation, and postoperative atrial Fibrillation.;   Changes in biochemical markers in both groups.;   Changes in echocardiographic parameters in both groups.;   Frequency, duration, characteristics and risk factors for postoperative atrial Fibrillation in patients with valve disease (without history of previous arrhythmia) undergoing cardiac surgery.;   Clinical and hemodynamic consequences of postoperative atrial Fibrillation after cardiac surgery.;   Prolongation of in-hospital and Intensive Care Unit (ICU) stay and the need for new drug or interventionism therapies, directly related to its appearance.

These studies may lead to new treatments and are adding insight into Fibrillation etiology and treatment.

A major focus of Fibrillation research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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