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Fidaxomicin Medical Research Studies

Up-to-date List of Fidaxomicin Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Fidaxomicin Medical Research Studies

Rank Status Study
1 Recruiting Safety and Efficacy of Fidaxomicin Versus Placebo for Prophylaxis Against Clostridium Difficile-Associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation
Condition: Clostridium Difficile-Associated Diarrhea (CDAD)
Interventions: Drug: Fidaxomicin;   Drug: placebo
Outcome Measures: The occurrence of CDAD from start of study treatment up to 30 days post-treatment follow-up in HSCT subjects.;   Occurrence of CDAD from start of study treatment up to 60 days post-treatment
2 Recruiting Study to Assess Inhibition of Spore Production in Patients With C. Difficile Infections: Fidaxomicin Versus Vancomycin
Condition: Clostridium Difficile Infection
Interventions: Drug: Vancomycin;   Drug: Fidaxomicin
Outcome Measure: The change in quantity of Clostridium difficile (both vegetative cells and spores) found within the stool of patients
3 Recruiting Impact of Oral Antibiotic Treatment on C. Difficile
Conditions: C. Difficile;   Diarrhea;   Enterocolitis
Interventions: Drug: Fidaxomicin;   Drug: Metronidazole;   Drug: Vancomycin
Outcome Measures: Change in variation of the profile of C. difficile isolated from specific body sites of a patient with microbiology-proven CDAD;   Change in variation in the profile of C. difficile isolated from targeted surfaces in a hospital;   Extent and quantity of C. difficile shedding, colonization and environmental contamination in patients who received oral Fidaxomicin vs. oral metronidazole or vancomycin;   Duration of diarrhea that were positive for CDAD
4 Recruiting To Determine the Feasibility of a Fidaxomicin Study in Neonates and to Assess C. Difficile (Clostridium Difficile) Involvement in the Pathogenesis
Condition: Clostridium Difficile
Intervention:
Outcome Measure: To determine the feasibility of a potential interventional study with Fidaxomicin
5 Recruiting A Study to Compare Safety and Efficacy of OPT-80(Fidaxomicin) With Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea (CDAD)
Condition: Clostridium Difficile
Interventions: Drug: OPT-80;   Drug: vancomycin
Outcome Measures: Global cure rate;   Cure rate;   Recurrence rate of CDAD;   Time to resolution of diarrhea;   Microbiological efficacy;   Plasma concentration of OPT-80(Fidaxomicin);   Plasma concentration of OP-1118;   Fecal concentration of OPT-80(Fidaxomicin);   Fecal concentration of OP-1118;   Safety assessed by the incidence of adverse events, vital signs, ECGs and laboratory tests
6 Recruiting A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002)
Condition: Clostridium Difficile Infection
Interventions: Biological: MK-6072;   Biological: MK-3415A;   Biological: Placebo;   Drug: SOC
Outcome Measures: Number of participants with CDI recurrence;   Number of participants with Global Cure;   Number of participants with CDI recurrence in those with clinical cure of the initial CDI episode
7 Recruiting A Study of MK-3415, MK-6072, and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-001)
Condition: Clostridium Difficile Infection
Interventions: Biological: MK-3415;   Biological: MK-6072;   Biological: MK-3415A;   Biological: Placebo;   Drug: SOC
Outcome Measures: Number of participants with Clostridium difficile infection (CDI) recurrence;   Number of participants with Global Cure;   Number of participants with CDI recurrence in those with clinical cure of the initial CDI episode

These studies may lead to new treatments and are adding insight into Fidaxomicin etiology and treatment.

A major focus of Fidaxomicin research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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