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Flex Medical Research Studies

Up-to-date List of Flex Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Flex Medical Research Studies

Rank Status Study
1 Recruiting A Study on the Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Tizanidine in Patients With BRAFV600 Mutation-Positive Metastatic Malignancies
Condition: Malignant Melanoma, Neoplasms
Interventions: Drug: vemurafenib;   Drug: tizanidine
Outcome Measures: Pharmacokinetics of tizanidine under conditions of vemurafenib steady-state exposure: Area under the concentration-time curve (AUC);   Pharmacokinetics of tizanidine under conditions of vemurafenib steady-state exposure: Maximum plasma concentration (Cmax);   Pharmacokinetics of tizanidine under conditions of vemurafenib steady-state exposure: Time to maximum plasma concentration (Tmax);   Pharmacokinetics of tizanidine under conditions of vemurafenib steady-state exposure: Terminal half-life (t1/2);   Pharmacokinetics of tizanidine under conditions of vemurafenib steady-state exposure: Apparent clearance (CL/F);   Safety: Incidence, nature and severity of adverse events and serious adverse events, graded according to the NCI CTAE (Version 4.0)
2 Recruiting Tizanidin and Pain After Herniorrhapy
Condition: Unilateral Inguinal Hernia
Interventions: Drug: Tizanidine;   Drug: Placebo
Outcome Measures: Visual analog scale pain score;   Likert score;   SF-36 score
3 Not yet recruiting Safety and Efficacy Study of an Etoricoxib and Tizanidine Fixed Dose Combination in Participants With Moderate to Severe Acute Low Back Pain (MK-0663B-164)
Condition: Low Back Pain
Interventions: Drug: MK-0663B;   Drug: DOLOCAM PLUS®;   Drug: Acetaminophen 500 mg
Outcome Measures: Number of Participants Experiencing an Adverse Event (AE);   Number of Participants Discontinuing Study Treatment Due to an AE;   Mean Change From Baseline in the Participant Low Back Pain Questionnaire Score;   Mean Change From Baseline in the Participant Roland Morris Disability Questionnaire;   Number of Participants With ≥30% Improvement From Baseline in the Roland Morris Disability;   Mean Change From Baseline in the Participant Global Assessment of Response to Therapy.;   Mean Change From Baseline in the Investigator Global Assessment of Response to Therapy;   Average Amount of Rescue Medication Required by Participant During Study Treatment;   Proportion of Participants Using Rescue Medication During Study Treatment
4 Recruiting Serotonergic Modulation of Motor Function in Subacute and Chronic SCI
Condition: Spinal Cord Injury
Interventions: Drug: Lexapro;   Drug: Placebo
Outcome Measures: Walking Index for Spinal Cord Injury (WISCI II);   Peak Treadmill Velocity;   Volitional Strength;   Gait kinematics;   Fastest possible walking velocity over ground (FV; m/s);   Six minute walking distance (m);   Lower Extremity Motor Scores (LEMS);   Modified Ashworth of knee extensors/flexors (ModAsh);   Spinal Cord Assessment Tool for Spasticity (SCATS)
5 Recruiting Monoaminergic Modulation of Motor Function in Subacute Incomplete Spinal Cord Injury (SCI)
Condition: Spinal Cord Injury
Interventions: Drug: Lexapro;   Drug: Placebo
Outcome Measures: Walking Index for Spinal Cord Injury (WISCI II);   Peak treadmill velocity;   Volitional Strength;   Gait kinematics;   Fastest possible walking velocity over ground (FV; m/s);   Six minute walking distance (m);   Lower Extremity Motor Scores (LEMS);   Modified Ashworth of knee extensors/flexors (modAsh);   Spinal Cord Assessment Tool for Spasticity (SCATS)
6 Recruiting Observational Study for Assessment of the Effect of Fampyra on the Manual Function of Persons With Multiple Sclerosis
Condition: Multiple Sclerosis
Intervention:
Outcome Measures: Score of hand function tests;   Improvement in daily function;   Correlation between improvement in manual function and ambulation

These studies may lead to new treatments and are adding insight into Flex etiology and treatment.

A major focus of Flex research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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