sponsored
PatientsVille.com Logo

PatientsVille

Furosemide Medical Research Studies

Up-to-date List of Furosemide Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Furosemide Medical Research Studies

Rank Status Study
1 Unknown  Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers
Condition: Healthy Male and Female Volunteers
Interventions: Drug: Furosemide;   Drug: aminohippurate sodium
Outcome Measures: pharmacokinetic parameter of Furosemide (AUC-24);   pharmacodynamic parameter of Furosemide (Sodium excretion in the urine);   pharmacogenetic parameters;   pharmacokinetic of aminohippuric acid;   other pharmacokinetic parameter of Furosemide;   other pharmacodynamic parameter of Furosemide
2 Not yet recruiting The Use of Furosemide in Patients on Dialysis
Condition: End Stage Renal Disease
Interventions: Drug: Withdrawal of Furosemide;   Drug: Furosemide administration
Outcome Measures: 24 hour urine sodium and water excretion;   Interdialytic weight gain
3 Recruiting Oral Metolazone and Intermittent Intravenous Furosemide Versus Continuous Infusion Furosemide in Acute Heart Failure
Condition: Acute Decompensated Heart Failure
Interventions: Drug: Intravenous Bolus Furosemide and Oral Metolazone;   Drug: Intravenous Continuous Infusion Furosemide
Outcome Measures: Daily net fluid output;   Patient Global Assessment Scale;   Daily urine output (mL urine out per mg Furosemide received);   Need for additional or alternative diuretic (crossover) or IV vasoactive therapy (study failure);   Death, rehospitalization, and unscheduled visit for HF to an emergency department or outpatient clinic;   Critically low potassium (< 3.5 mmol/L) and magnesium (< 1.6 mg/dL) concentrations;   Change in blood urea nitrogen or creatinine;   Number of hypotensive episodes defined as systolic blood pressure below 85 mmHg or greater than 10 mmHg below baseline (whichever is greater);   Total number of times antihypertensive doses are held due to low blood pressure
4 Unknown  Dopamine in Acute Decompensated Heart Failure (DAD-HF) Trial
Condition: Acute Heart Failure
Interventions: Drug: Furosemide;   Drug: low-dose dopamine + low-dose Furosemide
Outcome Measures: 1-year mortality or rehospitalization (all-cause, cardiovascular, non-cardiovascular, and due to worsening heart failure).;   60-day mortality or rehospitalization (all-cause, cardiovascular, non-cardiovascular, and due to worsening heart failure).
5 Unknown  The Influence of Furosemide on Fluid Balance and Intra-abdominal Pressure in Critically Ill Patients
Condition: Intra-Abdominal Hypertension
Intervention: Drug: Furosemide
Outcome Measures: intra-abdominal pressure;   serum creatinine;   need for renal replacement therapy;   ICU mortality;   acid-base status;   hospital and 28d mortality;   duration of mechanical ventilation;   ICU length of stay;   vasopressor dose;   fluid balance;   SOFA score
6 Not yet recruiting Inhaled Furosemide & Dyspnea
Condition: Dyspnea
Interventions: Other: CWS;   Drug: Furosemide;   Drug: Placebo
Outcome Measure: Sensory intensity (Borg 0-10 scale) ratings of dyspnea at isotime
7 Recruiting Peritoneal Dialysis vs Furosemide for Acute Kidney Injury After Cardiopulmonary Bypass
Condition: Acute Kidney Injury
Interventions: Drug: Furosemide;   Procedure: Peritoneal Dialysis
Outcome Measures: Fluid Balance;   Respiratory Support Administered;   NGAL Concentration;   Duration of cardiac ICU stay;   Duration of hospital stay;   All cause mortality;   Renal/electrolyte abnormalities;   Doses of Potassium Chloride or Arginine Chloride required;   B-Natriuretic Peptide
8 Recruiting Furosemide in Early Acute Kidney Injury
Condition: Acute Renal Failure
Interventions: Drug: Furosemide;   Drug: Normal Saline
Outcome Measures: Worsening AKI;   Fluid balance;   Renal replacement therapy (RRT);   Renal Recovery;   Survival
9 Unknown  Effect of Acetazolamide and Furosemide on Obesity-induced Glomerular Hyperfiltration
Condition: Obesity-induced Hyperfiltration
Intervention: Drug: Furosemide, acetazolamide
Outcome Measure: change in GFR and RPF
10 Recruiting Trial on Treatment With Inhaled Furosemide of Preterm and Term Neonates With Transient Tachypnoea
Condition: Transient Tachypnoea of the Newborn
Interventions: Drug: Furosemide;   Drug: Saline 0,9%
Outcome Measures: Reduction of the Silverman-Score;   Oxygen supplementation;   A need for secondary intubation and mechanical ventilation;   body weight;   CPAP-time;   blood electrolytes (Na+, K+, Ca++, HCO3-, Cl-);   blood gas (pH, pCO2,pO2)
11 Recruiting Furosemide Versus Ethacrynic Acid in Children With Congenital Heart Disease
Condition: Fluid Overload
Interventions: Drug: Furosemide;   Drug: ethacrynic acid
Outcome Measures: Mean total urine output production in the first post-operative day;   Mean creatinine and NGAL values
12 Unknown  Using Furosemide to Prevent Fluid Overload During Red Blood Cell Transfusion in Neonates
Condition: Lung Disease
Interventions: Drug: Furosemide;   Drug: Saline
Outcome Measures: Cardiac chamber volume loading.;   Clinical cardio-respiratory stability (heart rate, blood pressure, respiratory rate, oxygen saturation, and oxygen requirement).;   Myocardial performance, cardiac input and output and pulmonary hemodynamics (echocardiograph exam).;   Changes in electrolyte balance, body weight and urine output.
13 Not yet recruiting Furosemide Treatment Before Blood Transfusion in Patients With Systolic Dysfunction
Condition: Anemia Treatment Among Patients Suffering From Left Ventricular Systolic Dysfunction
Interventions: Drug: Furosemide;   Drug: placebo normal saline
Outcome Measures: Diastolic echocardiographic changes following blood transfusion, with or without Furosemide treatment;   clinical outcome following blood transfusion, with or without Furosemide treatment
14 Unknown  Stop Hypernatremia, Use Metolazone, for Aggressive, Controlled, Effective Diuresis
Conditions: Respiratory Failure;   Volume Overload;   Hypernatremia
Interventions: Drug: Supplemental metolazone diuresis;   Drug: Placebo Comparator: Control-- Furosemide (lasix) only
Outcome Measures: Fluid balance;   Serum sodium;   Hyponatremia;   Time to extubation;   Acute Kidney Injury
15 Recruiting Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function
Conditions: Chronic Kidney Insufficiency;   Hemodialysis Treatment;   Diuresis Preserved
Intervention: Drug: Hydrochlorothiazide and Furosemide
Outcome Measures: To asses the effect of combined hydrochlorothiazide-Furosemide therapy on weight gain between haemodialysis sessions in patients with RRF;   To asses the effect of combined hydrochlorothiazide-Furosemide therapy on dialytic, clinical and analytical variables and use of the antihypertensive treatment
16 Not yet recruiting The Impact of TORasemide oN hemodynAmic and Neurohormonal Stress, and carDiac remOdeling in Heart Failure
Condition: Heart Failure
Interventions: Drug: Furosemide;   Drug: Torasemide
Outcome Measures: The influence of therapy on cardiovascular events associated with heart failure (deaths, hospitalisations);   The change of dosing of diuretic due to worsening of condition of patient.;   The change of NYHA (New York Heart Association) class - worsening or improvement
17 Unknown  Comparing the Effects of Conivaptan and Diuretics on Plasma Neurohormones and Renal Blood Flow in Patients With Chronic Congestive Heart Failure
Condition: Heart Failure
Interventions: Drug: Conivaptan;   Drug: Furosemide;   Drug: Conivaptan and Furosemide
Outcome Measures: renal hemodynamics renal blood flow and glomerular filtration rate;   measure plasma neurohormone levels
18 Unknown  The Effect of Continuous, Various Doses of Furosemide Drip on Hearing as Measured by Acoustic Emission
Condition: Hearing Status
Intervention:
Outcome Measure:
19 Recruiting Aerosol Inhalation Treatment for Dyspnea
Conditions: Healthy;   Dyspnea
Intervention: Drug: Furosemide
Outcome Measures: Subject rating of Breathing Discomfort (dyspnea);   Multidimensional Dyspnea Profile;   Urine output
20 Not yet recruiting A Study of MK-7145 in Participants With Renal Insufficiency (Part I) and Heart Failure With Renal Insufficiency (Part II) (MK-7145-011)
Conditions: Renal Impairment;   Heart Failure
Interventions: Drug: MK-7145 2 mg;   Drug: MK-7145 8 mg;   Drug: Furosemide;   Drug: Torsemide
Outcome Measures: Change from baseline in first 24hr UNa (Part I);   NT-proBNP values at 24 hours post last dose (Part II);   Fold change from baseline for serum creatinine (Part I);   Area under the concentration-time curve from time zero to 24 hours after dosing (AUC0-24hr) for MK-7145 (Part I);   Maximum plasma concentration (Cmax) for MK-7145 (Part I);   Trough plasma concentration (Ctrough) for MK-7145 (Part I);   Time to Cmax (Tmax) for MK-7145 (Part I);   Apparent terminal half-life (t1/2) for MK-7145 (Part I);   Serum creatinine measured at 24 hours post last dose (Part II);   Area under the concentration-time curve from time zero to 24 hours after dosing (AUC0-24hr) for MK-7145 (Part II);   Maximum plasma concentration (Cmax) for MK-7145 (Part II);   Trough plasma concentration (Ctrough) for MK-7145 (Part II);   Time to Cmax (Tmax) for MK-7145 (Part II);   Apparent terminal half-life (t1/2) for MK-7145 (Part II)

These studies may lead to new treatments and are adding insight into Furosemide etiology and treatment.

A major focus of Furosemide research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


Discuss Furosemide