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GEI Medical Research Studies

Up-to-date List of GEI Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest GEI Medical Research Studies

Rank Status Study
1 Unknown  Effects of Oral and Topical Sea Buckthorn Oil Treatments on Skin Aging
Condition: Skin Aging
Interventions: Other: Omega7 Sea Buckthorn Oil Cream;   Other: Base cream;   Dietary Supplement: SBA24 Sea Buckthorn Oil Capsule
Outcome Measures: Decrease of signs of skin aging;   Subjects self-assessment of the efficacy of the treatment
2 Recruiting Maintaining Cognitive Health in Aging Veterans
Condition: Healthy People Programs
Intervention: Other: Memory and Aging Course
Outcome Measures: Knowledge of Memory Aging Questionnaire-Revised;   Multifactorial Memory Questionnaire (MMQ)
3 Not yet recruiting Cardiac Energetics and Function in Normal Human Ageing
Conditions: Left Ventricular Function Systolic Dysfunction;   Left Ventricular Function Diastolic Dysfunction;   Ageing
Intervention: Drug: Ramipril
Outcome Measures: Vascular Stiffness;   Left Ventricular Energetics;   Left Ventricular Function;   Effects of ACE inhibitor on left ventricular energetics and function in those subjects aged 40 and over
4 Recruiting A Prospective, Observational Study to Examine the Effects of Ageing on the 'Pharmacokinetic and Clinical Observations in People Over Fifty'
Conditions: HIV Positive;   Ageing
Intervention:
Outcome Measures: clinical manifestations of Ageing;   variations of anti-retroviral medication associated with age.;   to assess the potential impact of age on drug efficacy, drug-drug interactions and co-morbidities.
5 Recruiting Arthritis Foundation Exercise Program & "10 Keys" to Healthy Aging--Prevention Research Center
Conditions: Arthritis;   Diabetes;   Hypertension;   Preventive Behaviors
Interventions: Behavioral: AFEP;   Behavioral: "10 Keys" to Healthy Aging
Outcome Measures: Preventive Behaviors;   Joint Pain & Stiffness;   Cholesterol (LDL);   Glucose
6 Unknown  The Role of the "Inflammatory/ Pathogen Burden" for Cardiac Ageing
Conditions: Aging;   Inflammation
Intervention: Drug: fluvastatin
Outcome Measures: reduced narrowing of heart rate variability (measured by SDNN of a standardised 20 minute- resting-ecg) via lowering inflammatory/ pathogen burden by anti-inflammatory measures (standardized physical activity and statin administration);   quality of life;   inflammatory parameters;   major adverse cardiac events (MACE)including death, non lethal myocardial infarction and hospitalisation for cardiovascular reason;   inflammatory parameters in vaccinated and unvaccinated probands;   heart rate variability in vaccinated and unvaccinated probands;   evidence of reduced narrowing of heart rate variability (measured by SDNN of a 24-hours-holter-ecg) via lowering inflammatory/ pathogen burden by anti-inflammatory measures (standardized physical activity and statin administration)
7 Recruiting Glutathione and Fuel Oxidation in Aging
Condition: Aging
Intervention: Dietary Supplement: Glycine, cysteine (as n-acetylcysteine), alanine
Outcome Measure: Muscle glutathione concentration
8 Recruiting Translation Evaluation of Aging, Inflammation and HIV in Lung Function (TEAL)
Conditions: HIV;   COPD;   Pulmonary Disease;   Aging
Interventions: Procedure: PFT;   Procedure: lab work;   Procedure: 6MWT;   Other: questionnaires
Outcome Measures: Number of HIV+ individuals with increased lung dysfunction disproportionate to age.;   Number of HIV COPD patients with increased immune cell and lung cellular aging.;   Measurement of the inflammome in HIV-associated lung disease.;   Measurement of Pulmonary immune cell senescence in HIV+ individuals with poor lung function.;   The number of lung epithelial cell senescence in HIV+ individuals.
9 Recruiting Baltimore Longitudinal Study of Aging
Condition: Aging
Intervention:
Outcome Measure: Identify differences in health and functional status that cannot be attributed to disease among different individuals.
10 Recruiting DO-HEALTH / Vitamin D3 - Omega3 - Home Exercise - Healthy Ageing and Longevity Trial
Condition: Improve Healthy Ageing in Seniors; Prevent Disease at Older Age
Interventions: Drug: Vitamin D3;   Drug: Omega 3 fatty acids;   Procedure: Strength Home Exercise;   Procedure: Flexibility Home Exercise
Outcome Measures: Bone: Incident non-vertebral fractures;   Muscle: Functional decline (lower extremity function);   Cardio-vascular: Systolic and diastolic blood pressure change;   Brain: Cognitive decline;   Immunity: Rate of infections;   Bone: Incident hip fractures;   Bone: Incident total fractures;   Bone: Incident vertebral fractures;   Bone: Bone mineral density decrease at the lumbar spine and hip;   Muscle: Rate of falls;   Muscle: reaction time and grip strength;   Muscle: Muscle mass decrease at upper and lower extremities;   Muscle: Dual tasking 10-meter gait speed;   Muscle/Bone: musculoskeletal pain;   Cardio-vascular: Incident Hypertension;   Brain: mental health decline;   Brain: Incident Depression;   Brain/Muscle: Dual tasking gait variability;   Immunity: Rate of upper respiratory infections / rate of flu-like illness;   Immunity: Incident severe infections that lead to hospital admission;   Cartilage/Bone: Severity of knee pain in participants with symptomatic knee osteoarthritis;   Cartilage/Bone: Rate of knee buckling;   Cartilage/Bone: NSAID use / number of joints with pain;   Dental: Decline in oral health;   Dental: Tooth loss;   Gastro-Intestinal: rate of GI symptoms;   Glucose-Metabolic: Change in fasting glucose, insulin levels (QUICKI, HOMA index);   Glucose-Metabolic: Body composition;   Kidney: Decline in kidney function;   Global Health: Quality of life;   Global Health: Incident disability regarding activities of daily living;   Global Health: Incident nursing home admission;   Global Health: Mortality
11 Recruiting Muscle Insulin Resistance In Aging
Condition: Aging
Interventions: Other: Exercise training protocol;   Other: Dietary;   Other: Educational control.
Outcome Measure: muscle biopsy
12 Recruiting Effects of Exercise Intervention on Aging-related Motor Decline
Conditions: Aging;   Exercise
Interventions: Behavioral: Coordination training;   Behavioral: Short Term exercise - supervised;   Behavioral: Long Term Exercise
Outcome Measures: Motor Dexterity Score Improvement;   Interhemispheric Inhibition Improvement after Exercise;   Enhanced Interhemispheric Inhibition Improvement after Long Term Exercise
13 Recruiting Epigenetics in the Aging Process
Condition: Aging
Intervention:
Outcome Measure:
14 Recruiting Neurocognitive Study for the Aging
Conditions: Aging;   Memory Impairment;   Cognitive Decline;   Mild Cognitive Disorder
Intervention: Behavioral: Categorization training
Outcome Measure:
15 Recruiting Comorbidity and Aging With HIV
Conditions: HIV-1-infection;   Comorbidity;   Ageing
Intervention:
Outcome Measures: The prevalence of comorbidities, organ system dysfunction and their risk factors at time of enrolment;   The incidence of comorbidities, organ system dysfunction and their risk factors after two years of follow up;   Quality of life;   Management strategies
16 Recruiting Functional Impact of a Memory Intervention Program
Condition: Aging
Intervention: Behavioral: Memory and Aging Program
Outcome Measures: Change from baseline in healthy lifestyle behaviours as measured by Health Promoting Lifestyle Profile II (Walker, Sechrist, & Pender, 1987);   Change from baseline in memory strategy use as measured by the Memory Strategy Toolbox (modified from Troyer, 2001);   Attainment of individualized goals for (a) lifestyle change, (b) memory strategy use, and (c) functional outcomes of memory strategy use as measured by Goal Attainment Scaling (Gordon, Powell, & Rockwood, 2000; Kiresuk, Smith, & Cardillo, 1994);   Change in positive and negative affect as measured by Positive and Negative Affect Schedule (Watson, Clark, & Tellegen, 1988);   Change in general health status as measured by the RAND 36-Item Short-Form Health Survey (Ware & Sherbourne, 1992).
17 Recruiting Sodium Nitrite to Treat Arterial Aging
Condition: Vascular Aging
Interventions: Drug: Placebo;   Drug: Sodium Nitrite
Outcome Measures: Change from Baseline in Flow-Mediated Dilation at Week 4 and Week 10;   Change from Baseline in Plasma Nitrite at Week 10;   Reduction in Flow-Mediated Dilation to Forearm Ischemia/Reperfusion Injury;   Change from Baseline Aortic Pulse Wave Velocity at Week 4 and Week 10
18 Recruiting Ovarian Aging in Low Grade Glioma (LGG) Treated With Temozolomide
Condition: Low Grade Glioma
Intervention:
Outcome Measure: Ovarian Aging (AFC and Hormones)
19 Unknown  Chronic HIV Infection and Aging in NeuroAIDS (CHAIN)
Conditions: HIV;   Aging
Intervention: Other: Observational
Outcome Measures: Evaluate the feasibility of enrolling older HIV-infected patients and younger controls into a prospective, observational study.;   Selection of the optimal test battery to measure the areas of interest;   Participant acceptance of the measures involved;   Preliminary data collection to inform the size and design of a larger, follow-up study.
20 Recruiting Effects of Cocoa Flavanol on Skin Aging
Conditions: Ageing;   Photo-aging
Intervention: Dietary Supplement: Cocoa flavanol beverage
Outcome Measures: Change from baseline in skin wrinkles at week 24;   Change from baseline in skin elasticity at week 24;   Change from baseline in minimal erythema dose at week 24;   Change from baseline in skin hydration at week 12;   Change from baseline in skin color at week 12

These studies may lead to new treatments and are adding insight into GEI etiology and treatment.

A major focus of GEI research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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