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Gabapentin Medical Research Studies

Up-to-date List of Gabapentin Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Gabapentin Medical Research Studies

Rank Status Study
1 Recruiting Blinded, Randomized Study of Gabapentin (Neurontin®) and Gabapentin Enacarbil (Horizant™) in Restless Leg Syndrome
Condition: Restless Leg Syndrome
Interventions: Drug: Gabapentin immediate release (Neurontin);   Drug: Gabapentin enacarbil extended release (Horizant)
Outcome Measures: International Restless Leg Syndrome Rating Scale (IRLS);   Restless Leg Syndrome Quality of Life Scale (RLSQoL)
2 Not yet recruiting Pain Control in Pediatric Posterior Spine Fusion Patients: The Effect of Gabapentin
Condition: Pain, Postoperative
Interventions: Drug: Gabapentin;   Drug: Simple Syrup
Outcome Measures: Difference in pain control when adding Gabapentin to a multimodal pain management protocol in pediatric post-operative posterior spinal fusion patients.;   Determine if opiate usage is less in the Gabapentin group versus control.
3 Recruiting Effectiveness of Gabapentin on Chronic Irritability in Neurologically Impaired Children
Conditions: Neurologically Impaired;   Irritable Mood;   Signs and Symptoms, Digestive;   Sleeplessness;   Chronic Pain
Interventions: Drug: Gabapentin;   Drug: placebo
Outcome Measures: Symptom relief for chronic irritability in neurologically impaired children using Gabapentin.;   Prevalence of associated gastrointestinal and sleep problems in neurologically impaired children and improvement using Gabapentin.
4 Recruiting The Effect of Gabapentin on Thoracic Epidural Analgesia Following Thoracotomy
Condition: Pain, Postoperative
Interventions: Drug: Gabapentin;   Drug: Placebo
Outcome Measures: Persistent post surgical pain;   Acute postoperative pain;   Usage of epidural infusion of local and opioid analgesics (ml);   Early postoperative pain;   Consumption of opioid analgesics;   Time to first request for additional analgesics;   Analgesia related side-effects;   Convalescence of gastrointestinal function;   Health related quality of life;   Patient satisfaction;   Intensity of preoperative anxiety;   Convalescence of lung function (spirometry);   Sleep quality;   Walking distance (meters);   Fatigue;   Hospital length of stay (days);   Use of a vasopressor agent to correct hypotension
5 Recruiting Postoperative Tramadol/Gabapentin/Acetaminophen Versus Tramadol/Placebo/Acetaminophen
Condition: Pain
Interventions: Drug: Gabapentin;   Drug: Tramadol;   Drug: Ibuprofen
Outcome Measures: Efficacy of scheduled tramadol + PRN ibuprofen vs. scheduled tramadol + scheduled Gabapentin + PRN ibuprofen;   Side effects of scheduled tramadol + PRN ibuprofen vs. scheduled tramadol + scheduled Gabapentin + PRN ibuprofen
6 Recruiting Does a Perioperative Course of Gabapentin Improve Analgesia After Cesarean Delivery?
Condition: Pain
Interventions: Drug: Gabapentin;   Drug: lactose
Outcome Measures: VAS score (VAS 0-100 mm) for maternal pain on movement at 24 hours after surgical incision.;   VAS score on movement at 48 hours after surgical incision;   VAS scores at rest at 24 and 48 hours after surgical incision;   Maternal satisfaction scores at 24 and 48 hours after surgical incision.;   Opioid use in the first 48 hours after surgical incision;   Time to first analgesic;   Sedation;   Neonatal apgar scores;   Breastfeeding issues;   NICU admission
7 Recruiting Quality of Life Study Using Gabapentin Versus Venlafaxine in Treating Hot Flashes in Patients With Prostate Cancer
Condition: Hot Flashes in Men With Prostate Cancer Receiving Androgen Ablation Therapy
Interventions: Drug: Gabapentin;   Drug: Venlafaxine
Outcome Measures: Changes in quality of life;   compare toxicity rates between the Gabapentin and venlafaxine treatment groups;   Assess changes in the hot flash scores for the two arms;   Assess changes in quality of life using the Hot flash related Daily Interference Scale (HFRDIS)
8 Recruiting Gabapentin for Insomnia Symptoms and Nighttime Vasomotor Symptoms in Peri- and Postmenopausal Women
Conditions: Menopause;   Hot Flashes;   Vasomotor Disturbance
Intervention: Drug: Gabapentin
Outcome Measures: Tolerability of Gabapentin;   VMS frequency, severity, and bothersomeness;   Subjective sleep quality;   Anxiety;   Depressed mood
9 Recruiting A Trial of Gabapentin in Vulvodynia: Biological Correlates of Response
Condition: Vulvodynia
Intervention: Drug: Gabapentin extended-release
Outcome Measures: The primary outcome measure of this project are to test the prediction that pain from tampon insertion is lower in PVD patients when treated with Gabapentin compared to when treated with placebo.;   The secondary outcome measure is to perform a mechanism-based analysis of Gabapentin effectiveness, and to gain insight into the underlying pathophysiology of subtypes of PVD that may lead to more specific treatment options.
10 Recruiting Clinical Trial of Gabapentin to Improve Postoperative Pain in Surgical Patients
Condition: Postoperative Pain
Intervention: Drug: Gabapentin
Outcome Measures: Postoperative delirium and cognitive decline;   Postoperative opioid doses and pain scores
11 Unknown  Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy
Condition: Postoperative Pain
Interventions: Drug: Gabapentin;   Drug: pregabalin
Outcome Measure: Decreased overall pain score as measured by the visual analogue scale
12 Recruiting Safety and Efficacy of Gabapentin for Neuropathic Pain in Fabry Disease
Conditions: Fabry Disease;   Neuropathic Pain
Interventions: Drug: Gabapentin;   Drug: placebo
Outcome Measures: average reduction in hydrocodone-acetaminophen use;   Number and type of adverse events;   Pain levels;   Define therapeutic level for Gabapentin
13 Unknown  Gabapentin in Functional Dyspepsia Refractory to Proton Pump Inhibition
Condition: Functional Dyspepsia
Interventions: Drug: Gabapentin;   Drug: Placebo
Outcome Measures: The primary outcome will be the adequacy of symptom control during the last week of the study.;   Secondary outcomes equate dyspepsia symptoms with quality of life. The Nepean Dyspepsia Index scores patients on five categories while the Global Overall Symptom Scale measures the severity of dyspepsia on a 1-7 scale.
14 Recruiting Efficacy and Safety of Gabapentin in Treating Overactive Bladder
Conditions: Urinary Frequency;   Urinary Urgency;   Nocturia;   Incontinence;   Detrusor Uninhibited Activity;   Quality of Life
Interventions: Drug: Gabapentin;   Drug: Solifenacin Succinate;   Drug: Placebo drugs
Outcome Measures: improvement of symptom domain means decreased frequency to less than 8 micturitions per 24 hours, no urgency noted per 24 hrs and less that 3 wakening at bedtime for micturation.;   Improvement of bladder function domain means increased bladder capacity and decreased overactive detrusor as recorded in urodynamic study.;   Improvement in quality of life domain means increased overall quality of life as perceived and result in OAB-q
15 Not yet recruiting Effect of Gabapentin on Pain of the Second Cataract Surgery
Condition: Hyperalgesia
Interventions: Drug: Gabapentin;   Drug: placebo
Outcome Measures: proportion of subjects who answer that "pain was greater" in the second eye surgery;   perioperative pain
16 Recruiting Preoperative Gabapentin for Post-tonsillectomy Pain in Children
Condition: Post Operative Pain Management in Children With Tonsillectomy/Adenoidectomy
Interventions: Drug: Gabapentin;   Drug: liquid placebo
Outcome Measures: Total oral analgesia consumption;   Self-report pain score
17 Recruiting Gabapentin Treatment of Cannabis Dependence
Conditions: Cannabis Dependence;   Cannabis Withdrawal;   Cognitive Deficits
Interventions: Drug: Gabapentin 1200mg/day;   Drug: Placebo
Outcome Measure: Cannabis Use
18 Recruiting Steroids Versus Gabapentin
Conditions: Sciatica;   Radiculopathy
Interventions: Procedure: epidural steroid injection;   Procedure: Sham epidural steroid injection;   Drug: Gabapentin;   Drug: Placebo Gabapentin
Outcome Measures: leg pain;   Back pain;   Oswestry disability index;   satisfaction
19 Recruiting GRASSP: Gralise® for Spine Surgery Pain
Condition: Post-laminectomy Pain Syndrome
Interventions: Drug: Gralise®;   Drug: Placebo
Outcome Measures: Numeric Rating Scale (NRS);   Visual Analog Scale (VAS);   Patient Global Assessment (PGA);   McGill Pain Questionnaire-2 (MPQ-2);   Modified Brief Pain Inventory- short form (mBPI-sf);   Insomnia Severity Index (ISI)
20 Recruiting Maintenance Gabapentin to Prolong Pregnancy.
Condition: Preterm Labor, Premature Birth
Intervention: Drug: Gabapentin
Outcome Measure: Rate of premature birth (before 37 weeks gestation)

These studies may lead to new treatments and are adding insight into Gabapentin etiology and treatment.

A major focus of Gabapentin research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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