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Genteal Medical Research Studies

Up-to-date List of Genteal Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Genteal Medical Research Studies

Rank Status Study
1 Unknown  A Placebo Controlled Comparison of Topical Zirgan Versus Genteal Gel for the Treatment of Adenovirus Conjunctivitis
Conditions: Keratoconjunctivitis Due to Adenovirus;   Viral Shedding
Interventions: Drug: Zirgan;   Drug: Genteal gel
Outcome Measures: Time to Viral Eradication;   Development of sub-epithelial infiltrates;   Degree of Bulbar conjunctival Injection;   Second eye involvment
2 Recruiting A Trial of Topical Dexamethasone Versus Artificial Tears for Treatment of Viral Conjunctivitis
Condition: Viral Conjunctivitis
Interventions: Drug: dexamethasone 0.1%/povidone-iodine 0.4%;   Drug: Artificial Tears
Outcome Measures: Conjunctival injection;   Conjunctival chemosis
3 Unknown  Hydroxypropylmethylcellulose 0.3% and Sodium Hyaluronate 0.18% for Ocular Surface Disease in Glaucoma
Conditions: Ocular Surface Disease;   Glaucoma
Interventions: Drug: hydroxypropylmethylcellulose;   Drug: sodium hyaluronate
Outcome Measures: Ocular surface index score;   Eye lid inflammation, corneal staining score, tear break up time and tear volume
4 Not yet recruiting Efficacy and Safety Study of Bimatoprost 0.01% Alone Compared With Travoprost 0.004% and Timolol 0.5% in Subjects With Glaucoma or Ocular Hypertension
Conditions: Glaucoma;   Ocular Hypertension
Interventions: Drug: bimatoprost 0.01%;   Drug: travoprost 0.004%;   Drug: timolol 0.5%;   Drug: hypromellose 0.3%
Outcome Measure: Intraocular Pressure (IOP) in the Study Eye
5 Recruiting An Efficacy and Safety Study of Bimatoprost 0.01% Alone Compared With Travoprost 0.004% and Timolol 0.5% in Subjects With Glaucoma or Ocular Hypertension
Conditions: Glaucoma;   Ocular Hypertension
Interventions: Drug: bimatoprost 0.01%;   Drug: travatan 0.004%;   Drug: timolol 0.5%;   Drug: hypromellose 0.3%
Outcome Measure: Intraocular Pressure (IOP) in the Study Eye
6 Recruiting Hydroxypropyl Beta Cyclodextrin for Niemann-Pick Type C1 Disease
Condition: Niemann-Pick Disease, Type C1
Intervention: Drug: 2-hydroxypropyl-beta-cyclodextrin
Outcome Measures: 24-hydroxycholesterol Area under the curve;   Hearing loss.
7 Recruiting The Utility of in Vivo Confocal Microscopy to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With Dry Eye Disease
Condition: Dry Eye Disease
Interventions: Drug: Lotemax;   Drug: Artificial Tears
Outcome Measures: In Vivo Confocal Microscopy (IVCM): Superficial corneal epithelial cells: Density, size, and hypereflectivity;   In Vivo Confocal Microscopy: Corneal subbasal immune dendritiform cells: Density, size, and cell field;   In Vivo Confocal Microscopy: Corneal subbasal nerves: Number and length of the main nerves and the branches;   Ocular Signs: Corneal epitheliopathy;   Ocular Signs: Conjunctival epitheliopathy;   Ocular Signs: Tear Break Up Time (TBUT);   Ocular Signs: Schirmer's Test with Anesthesia;   Ocular Signs: Intraocular pressure (IOP) by measure of applanation tonometry;   Ocular Symptoms: Ocular Surface Disease Index (OSDI) questionnaire;   Ocular Symptoms: • Symptom Assessment iN Dry Eye (SANDE) questionnaire
8 Unknown  Comparison of Combination Antibiotics Eyedrop to Artificial Tear in Hordeolum After Incision and Curettage
Condition: Hordeolum
Interventions: Drug: neomycin sulfate, polymyxin B sulfate and gramicidin;   Drug: Artificial tear
Outcome Measures: Pain scale;   Mass size and duration of cure
9 Recruiting Efficacy and Safety of Fluorometholone (FML) in Dry Eye Disease (Keratoconjunctivitis Sicca)
Condition: Dry Eye
Interventions: Drug: FML 0.1% eyedrops;   Drug: Liquifilm artificial tears eyedrops
Outcome Measures: Fluorescein corneal staining;   Symptom Assessment in Dry Eye (SANDE) I and II questionnaire;   Tear inflammatory molecule levels;   Best corrected visual acuity;   Biomicroscopy findings at slit lamp examination;   Adverse events during the trial;   Other Efficacy Measures;   Intraocular pressure (IOP) and fundus examination
10 Recruiting Effects of Conventional Dry Eye Treatments on the Ocular Surface Response to Low Humidity Environment in Patients With Keratoconjunctivitis Sicca
Conditions: Keratoconjunctivitis Sicca;   Dry Eye Syndrome
Intervention: Drug: dexamethasone, artificial tears
Outcome Measure: Changes in ocular surface measured by routine opthalmic dyes
11 Recruiting Effect of Topical Glaucoma Therapy on Tear Film Stability in Healthy Subjects
Condition: Healthy
Interventions: Drug: Timoptic® 0.5%;   Drug: Timophtal sine® 0.5%;   Device: Genteal HA®;   Device: Hylo-Comod®;   Device: Thealoz®
Outcome Measures: Tear film thickness;   Break up time (BUT)
12 Recruiting Fluorometholone as Ancillary Therapy for TT Surgery
Conditions: Trichiasis;   Trachoma;   Bilamellar Tarsal Rotation
Interventions: Drug: Fluorometholone 0.1% ophthalmic solution;   Other: Artificial tears (Placebo)
Outcome Measures: Safety assessments;   Recurrence of trichiasis in the study eye
13 Not yet recruiting Assessment of Tear Film Thickness by Optical Coherence Tomography in Healthy Subjects and Subjects With Dry Eye Disease
Condition: Dry Eye Syndrome
Interventions: Device: Genteal HA® Eye Drops (NOVARTIS, Switzerland);   Other: Physiological Sodium Chloride solution (0,9%)
Outcome Measures: Tear film thickness;   Schirmer I Test;   Tear Break Up Time;   Ocular Surface Disease Index
14 Recruiting A Phase IV, Randomized, Parallel Group, Investigator-Masked Evaluation of the Effect of Loteprednol Etabonate Ophthalmic Gel 0.5% on the Initiation of Dry Eye Treatment With Restasis®
Condition: Dry Eye Disease
Interventions: Drug: Loteprednol etabonate;   Drug: Artificial Tears;   Drug: Restasis
Outcome Measures: Fluorescein corneal staining scores;   Lissamine green conjunctival staining
15 Not yet recruiting Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study)
Condition: Graves' Ophthalmopathy
Interventions: Drug: Bimatoprost;   Drug: Eye drop solution
Outcome Measures: The primary endpoint of this study will be comparison of the change in ophthalmometry readings over the two 3 month treatment periods.;   Change in quality of life scores on the TED quality of life questionnaire (GO-QOL);   Intraocular pressures;   Side effects;   Health economic outcomes
16 Recruiting Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol
Conditions: Sturge Weber Syndrome;   Port Wine Mark
Interventions: Drug: Timolol;   Drug: Preservative free artificial tear gel.
Outcome Measure: Appearance of Port-wine Mark at treatment site
17 Recruiting Steroids After Laser Trabeculoplasty for Glaucoma
Condition: Glaucoma
Interventions: Drug: Prednisolone 1%;   Drug: Diclofenac 0.1%;   Drug: Artificial Tears
Outcome Measures: Intraocular pressure (IOP) lowering;   Intraocular inflammation
18 Unknown  Aqueous Humor Dynamics and Brimonidine
Condition: Intraocular Pressure
Interventions: Drug: Brimonidine;   Drug: Artificial tears
Outcome Measure: Aqueous Humor Dynamics
19 Recruiting Postoperative Subtenons Anesthesia for Postoperative Pain in Pediatric Strabismus Surgery
Condition: Strabismus
Interventions: Drug: subtenons anesthetic - preservative-free bupivacaine 0.75%;   Drug: topical anesthetic - 0.5 cc of lidocaine 3.5% ophthalmic gel;   Drug: topical control - 0.5 cc of Hypromellose 0.3% gel;   Drug: subtenons control - 0.5 cc of Normal Saline
Outcome Measures: Average pain score over the first 30 post-operative minutes using the CHEOPS scale;   Peak pain score in the first 30 minutes;   Total narcotic and anti-emetic use during post-operative recovery;   Negative postoperative behavior score on the PHBQ (post hospitalization behavioral questionnaire);   Change in pain score
20 Unknown  Evaluation of Blood as a Submucosal Cushion During Endoscopic Polypectomy and Mucosal Resection
Condition: Large Polyps in the Gastrointestinal Tract
Interventions: Drug: Autologous blood injection;   Drug: Normal saline;   Drug: HPMC
Outcome Measures: Duration of the submucosal cushion Ease of injection Ability to complete lesion removal Post-procedure complications;   Ability to perform lesion removal Ability to visualize during the procedure

These studies may lead to new treatments and are adding insight into Genteal etiology and treatment.

A major focus of Genteal research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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