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Gingival Medical Research Studies

Up-to-date List of Gingival Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Gingival Medical Research Studies

Rank Status Study
1 Unknown  Diode Laser in Gingival Enlargement Related to Orthodontics
Condition: Gingival Overgrowth
Intervention: Procedure: Laser gingivectomy
Outcome Measure: Gingival Overgrowth Index
2 Recruiting Nicotine Gum Recovery After Colorectal Surgery
Condition: Post-operative Ileus
Interventions: Drug: Nicotine gum;   Other: Regular chewing gum
Outcome Measures: Bowel function recovery;   Hospital stay;   Post-operative vomiting;   Use of NG Tubes
3 Unknown  Effects of Gum Chewing on Recovery of Bowel Function Following Benign Gynecologic Surgery
Condition: Recovery of Bowel Function, Due to Gum Chewing
Intervention: Behavioral: Gum chewing
Outcome Measures: Time to first flatus;   Incidence and severity of postoperative nausea, vomiting and abdominal discomfort;   Incidence of postoperative complications;   Time to first regular diet;   Time to first defecation;   Hospital stay;   Patients's satisfaction
4 Unknown  Connective Tissue Graft Versus Mucograft Collagen Matrix for Coverage of Multiple Gingival Recession Defects
Condition: Gingival Recession
Interventions: Procedure: Autologous connective tissue graft with rotated papilla flap;   Device: Collagen matrix construct (Mucograft)
Outcome Measures: Time to recovery after surgery;   Complete root coverage;   Percentage of root coverage;   Esthetics
5 Unknown  Does Chewing Gum After Elective Laparoscopic Colectomy Surgery Decrease Ileus?
Condition: Ileus
Intervention: Other: chewing gum
Outcome Measure: Decrease ileus with intervention compared to standard post op care
6 Recruiting Gingival Clefts and Orthodontic Movement
Conditions: Gingival Clefts;   Extraction Socket;   Orthodontic Movement
Intervention: Other: time point of tooth extraction
Outcome Measure: incidence of Gingival clefts
7 Recruiting Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies
Condition: Postoperative Ileus
Intervention: Drug: gum
Outcome Measures: postoperative flatus pass time;   duration of hospital stay;   gastrointestinal disturbance;   time to first bowel movement;   Time to first defaecation
8 Not yet recruiting Role of Chewing Gum in Reducing Post Operative Ileus After Reversal of Ileostomy
Condition: Postoperative Ileus
Intervention: Other: Sugar Free Chewing Gum
Outcome Measure: passage of flatus
9 Recruiting The Effect of Chewing Gum on Small Bowel Transit Time
Condition: Bowel Transit Times
Interventions: Other: Trident sugarless chewing gum.;   Other: One control group (these do not chew gum).
Outcome Measures: Small bowel transit time;   Gastric transit time, cecal completion rate
10 Recruiting Characterizing Gingival and Periodontal Ligament Fibroblasts Reaction to Infection With the Bacteria Porphyromonas Gingivalis
Condition: Periodontal Disease
Intervention: Other: Specimens collection
Outcome Measures: Cytokines, inflammatory mediators and extracellular matrix proteins production and secretion in vitro by fibroblasts;   RNA production in vitro;   cells motion in vitro;   Cytokines, inflammatory mediators and extracellular matrix proteins production and secretion by leukocyte cell lines in vitro;   RNA production in vitro by leukocyte cell lines;   Bacterial survival;   Bacterial adherence to fibroblasts and leukocytes in vitro;   cell apoptosis (rate and speed)
11 Recruiting The Effect of Bone Grafts on Facial Gingival Profile in Maxillary Anterior Single Tooth Replacement
Condition: Facial Gingival Profile
Interventions: Procedure: bone graft inside socket only;   Procedure: bone graft inside and outside socket;   Procedure: no bone graft
Outcome Measure: change in facial Gingival profile
12 Unknown  Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer
Condition: Paralytic Ileus
Intervention: Behavioral: Gum chewing
Outcome Measures: Time to first flatus;   Incidence and severity of postoperative nausea, vomiting,and abdominal discomfort;   Incidence of postoperative complications;   Time to first regular diet;   Time to first defecation;   Postoperative analgesics requirement;   Hospital stay;   Patients' satisfaction
13 Recruiting Procedures for Improving the Mucosa Around Implants
Conditions: Keratinized Mucosa;   Dental Implants
Interventions: Procedure: Apically positioned flap;   Procedure: Free Gingival Graft;   Procedure: apically positioned flap with Mucograft
Outcome Measures: Pain and discomfort survey;   Evaluation of full mouth Gingival condition (periodontal parameters)
14 Unknown  The Effect of Gum Chewing on Postoperative Ileus
Condition: Perforated Appendicitis
Interventions: Device: Motion sickness wristband;   Dietary Supplement: Chewing Gum
Outcome Measure: Time to resolution of post-operative ileus.
15 Recruiting A Clinical Trial to Test the Effect of Experimental Mouth Rinse on Gum Disease
Condition: Gingivitis
Interventions: Other: Listerine Advance Gum Defense;   Other: Mouth rinse containing Chlorhexidine;   Other: Mouth rinse containing 5% Hydroalcohol
Outcome Measures: Whole Mouth Mean Bleeding Index (BI) at 4 weeks;   Whole Mouth Mean Bleeding Index (BI) at 1 week;   Whole-mouth Mean Modified Gingival Index (MGI);   Turesky Modification of the Quigley Hein Plaque Index (PI);   Extrinsic Stain
16 Recruiting A Double-Blind, Randomized, Controlled, Dose Escalation Clinical Trial of an Antiplaque Chewing Gum - Phase 1 Safety and Tolerability and Phase 2a Safety, Tolerability, and Proof of Concept in a Gingivitis Population
Conditions: Plaque;   Gingivitis
Interventions: Drug: 2 mg KSL-W;   Drug: 4 mg KSL-W;   Drug: 6 mg KSL-W;   Drug: 10 mg KSL-W;   Drug: 20 mg KSL-W;   Drug: 30 mg KSL-W;   Drug: 50 mg KSL-W;   Drug: 75 mg KSL-W;   Drug: 100 mg KSL-W;   Other: Placebo
Outcome Measures: Safety and tolerability of KSL-W as measured by soft tissue erythema, ulceration and sloughing.;   Proof of concept of KSL-W in reducing plaque as measured by Turesky modification of the Quigley-Hein Plaque Index(PI).;   Proof of concept of KSL-W in reducing gingivitis as measured by modified Gingival index (MGI);   Proof of concept of KSL-W in reducing plaque as measured percent of bleeding sites upon probing (BOP)
17 Unknown  Chromogranin-A-Derived Peptides and Periodontitis in Diabetic Patients
Condition: Periodontitis and Diabetitis
Intervention: Procedure: Gingival crevicular fluid samples (this procedure is added to the subject usual medical follow-up).
Outcome Measure:
18 Unknown  Effect of Xylitol on Oral Microbiota in Children
Condition: Bacterial Infections
Intervention: Dietary Supplement: xylitol
Outcome Measures: MS counts of stimulated saliva;   The changes in the counts of the 14 other bacterial species
19 Unknown  The Effect of Oral Hygiene and Full Mouth Scaling on Metabolic Control in Patients With Type II Diabetes
Conditions: Gingival Scaling;   Metabolic Control
Intervention: Procedure: Gingival scaling
Outcome Measures: Metabolic control;   Inflammation
20 Recruiting Efficacy of Iocide Oral Rinse Against Gingival Inflammation
Conditions: Gingivitis;   Investigation of Biological Markers of Inflammation
Interventions: Drug: Iocide Oral Rinse;   Drug: Placebo
Outcome Measures: Change in Mean Gingival Index (GI);   Change in Biological Marker Data

These studies may lead to new treatments and are adding insight into Gingival etiology and treatment.

A major focus of Gingival research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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