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Grapefruit Medical Research Studies

Up-to-date List of Grapefruit Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Grapefruit Medical Research Studies

Rank Status Study
1 Recruiting The Effect of Low Furanocoumarin Grapefruit Hybrid Juice Consumption on Midazolam Pharmacokinetics
Condition: Pharmacokinetics
Interventions: Other: Low furanocoumarin hybrid Grapefruit juice;   Other: Regular Grapefruit juice;   Other: Water (control)
Outcome Measures: Area under the plasma concentration-time curves;   Time to peak concentration;   Peak concentration
2 Unknown  Effects of a Long-term Grapefruit Juice Consumption on Vascular Protection and Bone Metabolism
Condition: Post-menopausal Status
Intervention: Behavioral: Long-term Grapefruit juice consumption
Outcome Measure:
3 Recruiting Transporter Mediated Uptake of Montelukast
Condition: Asthma
Interventions: Dietary Supplement: Grapefruit juice;   Dietary Supplement: Orange Juice;   Dietary Supplement: Gatorade
Outcome Measures: Area under the concentration vs. time curve for the serum concentration of montelukast when coingested with Grapefruit juice, orange juice, or Gatorade.;   Improvement in respiratory function as assessed by spirometry, and impulse oscillometry vs. serum concentration of montelukast.
4 Not yet recruiting CYP3A4 Induction and Mineral Homeostasis
Condition: Vitamin D and Calcium Homeostasis
Interventions: Drug: Rifampin;   Drug: Clarithromycin;   Other: Grapefruit Juice
Outcome Measures: 1, 25(OH) D3 Vitamin D;   25(OH) D3 Vitamin D;   Parathyroid Hormone;   Osteocalcin;   Calcium, total;   Calcium, ionized;   Calcium;   Phosphate
5 Recruiting Buprenorphine Disposition and Clinical Effects
Condition: Healthy
Interventions: Drug: Buprenorphine;   Drug: Rifampin;   Other: Grapefruit juice;   Drug: Ketoconazole
Outcome Measure: Area under the plasma concentration-time curve (AUC) of BPN and metabolites
6 Recruiting Effects of a CRF1 Receptor Antagonist on Human Startle in Normal Female Volunteers
Condition: Anxiety Disorders
Outcome Measure:
7 Recruiting Study of BKM120 in Advanced Squamous Cell Carcinoma of Head and Neck
Conditions: Head Neck Cancer Squamous Cell Metastatic;   Head Neck Cancer Squamous Cell Recurrent
Intervention: Drug: BKM120
Outcome Measures: Disease control rate at 8 weeks;   Overall response rate (ORR);   Toxicity profile;   Overall survival;   Progression-free survival;   Quality of life assessment;   Time to progression (TTP)
8 Recruiting Freezie Remedy to Alleviate Morning Sickness
Condition: Morning Sickness
Interventions: Other: Lillipops Iced Soothies;   Other: Mr. Freeze Freezies
Outcome Measures: Improvement of Nausea and Vomiting of Pregnancy (NVP);   Concurrent Symptoms;   Freezie Flavour Preference
9 Recruiting Sirolimus, Cisplatin, and Gemcitabine Hydrochloride in Treating Patients With Bladder Cancer
Conditions: Adenocarcinoma of the Bladder;   Recurrent Bladder Cancer;   Stage II Bladder Cancer;   Stage III Bladder Cancer;   Stage IV Bladder Cancer;   Transitional Cell Carcinoma of the Bladder
Interventions: Drug: sirolimus;   Drug: cisplatin;   Drug: gemcitabine hydrochloride;   Other: laboratory biomarker analysis;   Procedure: therapeutic conventional surgery
Outcome Measures: MTD of sirolimus based on the incidence of dose-limiting toxicity (DLT) graded according to the National Cancer Institute (NCI) Common Terminology Criterial for Adverse Events (CTCAE) version 4.0 (Phase I);   Percent of patients with pathologic complete response (Phase II);   DNA microenvironment damage response proteins using immunohistochemistry (IHC) assay;   DNA microenvironment damage-responsive transcripts by polymerase chain reaction (PCR);   Incidence of adverse events including any unfavorable and unintended sign, symptom, diagnosis, or disease temporally associated with the use of a medicinal product, whether or not related to the medicinal product (Phase I and II)

These studies may lead to new treatments and are adding insight into Grapefruit etiology and treatment.

A major focus of Grapefruit research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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