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Hemodialysis Medical Research Studies

Up-to-date List of Hemodialysis Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Hemodialysis Medical Research Studies

Rank Status Study
1 Unknown  Phosphorus and Calcium Removal During Long Hemodialysis Treatment Sessions
Condition: Kidney Failure
Intervention: Device: NxStage System One (NxStage Medical, Lawrence, MA)
Outcome Measure: the effect of dialysate volume and treatment time on phosphage and calcium removal
2 Recruiting Evaluation of Daily Hemodialysis at Low Dialysate Flow in Patients Previously Treated With Conventional Hemodialysis
Condition: End Stage Renal Disease
Intervention: Other: Daily Hemodialysis at low dialysate flow
Outcome Measures: Number of patients for whom the period of daily Hemodialysis at low dialysate flow will be a success.;   Number of patients who stopped the daily Hemodialysis at low dialysate flow (patient or investigator's decision).;   Number of patients who maintained a satisfactory clinical condition (investigator assessment) during the period of daily Hemodialysis at low dialysate flow.;   Evaluation of weight.;   Evaluation of blood pressure.;   Evaluation of heart rate.;   Evaluation of body mass index.;   Evaluation of metabolic parameters.;   Evaluation of hematological parameters.;   Evaluation of inflammation parameters.;   Evaluation of nutrition parameters.;   Evaluation of iron parameters.;   Change in hormones.;   Composite measurement of treatments.;   Composite measurement of technical dialysis parameters.;   List of symptoms and incidents between two Hemodialysis, evaluation of Hemodialysis tolerance, clinical assessment of the vascular access and possible local complications.;   Change in quality of life.;   Change in pain.
3 Unknown  New Needle for Two-Needle Hemodialysis
Condition: End Stage Renal Disease
Interventions: Procedure: Hemodialysis using the standard venous needle;   Procedure: Hemodialysis using a new venous needle, the "BME needle"
Outcome Measures: Net change in intracellular oxidative stress and intracellular proinflammatory cytokines levels;   Net change in oxidative stress and proinflammatory cytokines in plasma
4 Recruiting Blood Pressure Guided Biofeedback on Hemodialysis and the Reduction of IntraDialytic Hypotension
Condition: Hypotension
Interventions: Other: BioLogic RR;   Other: Hemodialysis without biofeedback
Outcome Measures: intradialytic hypotension episodes;   urea clearance;   Brain natriuretic peptide;   intradialytic hypotension (blood pressure criteria alone);   Intradialytic symptoms
5 Recruiting Conventional Hemodialysis Vs Short Daily Hemodialysis for Patients Coming From Home Automated Peritoneal Dialysis
Condition: End Stage Renal Disease
Interventions: Procedure: Short daily Hemodialysis;   Procedure: Conventional Hemodialysis
Outcome Measures: mean quality-adjusted life year (QALY) score in the first year after the start of dialysis;   dialysis related cost of care;   transportation costs per patient per year for the journeys "home-hospital-home";   transportation costs per patient per year for the journeys "home-hospital-home;   ratio nurse/patients;   hospitalization rate (admissions and days;   weekly standardized Kt/V delivered;   systolic blood pressure and use of antihypertensive medications;   mineral metabolism, anemia parameters and nutritional parameters;   maintenance of residual renal function
6 Recruiting Cerebral Microembolism During Hemodialysis
Conditions: Complication of Dialysis;   Thrombus Due to Renal Dialysis Device, Implant, or Graft;   Cerebral Embolism
Intervention: Device: Renal Hemodialysis (Fresenius 2008K, Bad Homburg, Germany)
Outcome Measures: Cerebral embolic load;   Quality of cerebral embolic load
7 Not yet recruiting Adjuvant Peritoneal Dialysis on a Background of Thrice-Weekly Hemodialysis
Conditions: Functionally Anuric;   Hemodialysis/Peritoneal Dialysis
Intervention: Other: Adjuvant Peritoneal Dialysis in the context of ongoing Hemodialysis
Outcome Measures: Frequency of adverse events;   baseline-to-follow up changes in inter-HD weight gain;   baseline-to-follow up changes in HD dry weight (lowest tolerated at each time point);   baseline-to-follow up changes in ambulatory blood pressures;   baseline-to-follow up changes in pre-HD serum phosphorus;   baseline-to-follow up changes in pre-to-post HD changes in serum potassium and total carbon dioxide (CO2);   baseline-to-follow up changes in Kidney Disease Quality of Life Short Form (KDQoL-SF) scores for physical functioning, energy fatigue, and general health
8 Unknown  The Pharmacokinetics of Nifedipine Controlled Release Tablets in Hypertensive Patients on Hemodialysis
Condition: Hypertension on Chronic Maintenance Hemodialysis
Intervention: Drug: nifedipine controlled release tablets
Outcome Measure: To investigate the effect and safety of nifedipine controlled release tablets in patients on chronic maintenance Hemodialysis by using ABPM.
9 Unknown  OPG and RANKL Plasma Level After Administration of Unfractionated Heparin (UFH) and Low-Molecular-Weight Heparin (LMWH) in Hemodialysis
Conditions: Renal Failure;   Hemodialysis
Interventions: Drug: law molecular weigth heparin;   Drug: unfractioned heparin
Outcome Measures: Levels of osteoprotegerin after administration of UFH or LMWH used as anticoagulant therapy for Hemodialysis;   Secondary aim of the study is to verify the safety of anticoagulation therapy with UFH and LMWH.
10 Recruiting Implantable Loop Recorder in Hemodialysis Patients
Conditions: Hemodialysis;   Cardiac Arrhythmia;   Cardiac Death
Intervention: Device: Implantation of ILR
Outcome Measures: Occurrence of arrhythmia;   Study correlation between arrhythmic events (primary outcome) and Hemodialysis parameters (general: day of dialysis, length of dialysis;clinical: weight variation during dialysis...; biological: potassium level, potassium variation...; ECG);   Incidence of supra-ventricular arrhythmia: 3A-Atrial Fibrillation, 3B-Atrial Tachycardia, 3C-Junctional tachycardia
11 Unknown  Comparison of Daily Nocturnal Hemodialysis With Daily Hemodialysis
Condition: Kidney Failure, Chronic
Intervention: Procedure: Hemodialysis
Outcome Measure:
12 Recruiting Pharmacokinetics of an Aminoglycoside in Hemodialysis Patients.
Condition: Renal Failure Chronic Requiring Hemodialysis
Intervention: Drug: Gentamicin
Outcome Measure: Concentration curves of gentamicin
13 Unknown  The Effect of Different Dosages of Solute Clearance on Outcome in Twice Weekly Hemodialysis Patients
Conditions: Renal Replacement Therapy;   Hemodialysis
Intervention: Procedure: modification of Hemodialysis parameters on dialysis machine
Outcome Measures: clinical outcome including mortality and morbidity;   complications including cardiovascular disease, nutritional and inflammation status, calcium and phosphorus level, anemia and life quality
14 Unknown  Short Daily Hemodialysis and Online HDF: Which One is Better?
Condition: End Stage Renal Disease
Interventions: Procedure: Online HDF;   Procedure: Short Daily Hemodialysis
Outcome Measures: Adequacy;   Hematocrit, calcium, phosphorus
15 Unknown  Effect of a Pre Heparin Coated Dialysis Filter on Coagulation During Hemodialysis
Condition: Renal Failure
Intervention: Device: a pre-heparin-coated Hemodialysis filter; Hepran
Outcome Measures: Activation of the intravascular coagulation system during Hemodialysis with use of a pre-heparin-coated filter compared to a conventional filter;   A secondary outcome measure is degree of clot score in the extracorporeal system during Hemodialysis with use of a pre-heparin-coated filter compared to the conventional filter.
16 Not yet recruiting Pharmacokinetics and Optimal Dose of Ertapenem in Hemodialysis Patients
Condition: End Stage Renal Disease
Intervention: Drug: Ertapenem
Outcome Measures: Mean maximum concentration (Cmax) of ertapenem in Hemodialysis patients;   Mean minimum concentration (Cmin) of ertapenem in Hemodialysis patients;   Mean area under the curve (AUC) of ertapenem in Hemodialysis patients;   Mean terminal elimination rate constant (ke) of ertapenem in Hemodialysis patients;   Mean terminal half life (t1/2) of ertpenem in Hemodialysis patients;   Mean time to Cmax of ertapenem in Hemodialysis patients;   Number of participants with diarrhea;   Number of participants with nausea and vomiting;   Number of participants with headache;   Number of participants with injection site reaction
17 Unknown  Effects of On-Line Hemodiafiltration(HDF) on Vascular Health in Chronic Hemodialysis Patients
Conditions: End Stage Renal Disease;   Hemodialysis
Interventions: Procedure: On-line hemodiafiltration;   Procedure: Low flux Hemodialysis
Outcome Measure: endothelial dysfunction measured by flow-mediated vasodilation
18 Unknown  More Frequent Dialysis (>3 Treatments Per Week)
Conditions: End Stage Renal Disease;   Chronic Kidney Disease
Interventions: Procedure: More frequent Hemodialysis;   Procedure: Conventional Hemodialysis
Outcome Measures: Hospitalization days per year;   Nutritional Status measured by Subjective Global Assessment;   Anemia, measured by erythropoetin dose;   Control of hypertension, as measured by number of antihypertensive tablets taken per day;   Control of hyperphosphatemia, as measured by number of phosphate binder tablets taken per day
19 Recruiting Continuous Venovenous Hemofiltration Versus Continuous Venovenuous Hemodialysis
Condition: Acute Renal Failure
Interventions: Procedure: Continuous Venovenous Hemofiltration (CVVH);   Procedure: Continuous Venovenous Hemodialysis (CVVHD)
Outcome Measures: To compare the clearance of urea and creatinine by RRT using continuous venovenous hemofiltration versus continuous venovenous Hemodialysis.;   To compare the clearance cystatin C and inflammatory cytokines (IL-6 and IL-10) by RRT using continuous venovenous hemofiltration versus continuous venovenous Hemodialysis.
20 Recruiting Comparison of Nocturnal Hemodialysis (NHD) and Short Daily Hemodialysis (DHD) With the NxStage® System One™
Conditions: Kidney Failure, Chronic;   End Stage Renal Disease, Requiring Dialysis
Intervention: Device: NxStage System One
Outcome Measure:

These studies may lead to new treatments and are adding insight into Hemodialysis etiology and treatment.

A major focus of Hemodialysis research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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