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Hydrocephalus Medical Research Studies

Up-to-date List of Hydrocephalus Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Hydrocephalus Medical Research Studies

Rank Status Study
1 Recruiting Cerebrospinal Fluid Proteome in Hydrocephalus
Condition: Normal Pressure Hydrocephalus
Interventions: Biological: patient CSF extraction with Hydrocephalus;   Biological: witness CSF extraction from patient not suffering from Hydrocephalus
Outcome Measures: CSF proteome measure;   correlation between CSF proteome and gait analysis;   correlation between CSF proteome and MRI brain imaging
2 Recruiting Ventricular Size Involvement in Neuropsychological Outcomes in Pediatric Hydrocephalus
Condition: Hydrocephalus
Intervention:
Outcome Measures: Association between ventricle size and neuropsychological outcome;   Quality of life;   Academic Performance;   Presence of additional required Hydrocephalus related surgeries
3 Recruiting HCRN Core Data Project: Characterizing Patient Populations in the Hydrocephalus Clinical Research Network (HCRN)
Condition: Pediatric Hydrocephalus
Intervention:
Outcome Measures: To describe the number and characteristics of neurosurgical Hydrocephalus patient events to HCRN Clinical Centers such as patient demographics, etiology of Hydrocephalus, diagnostic information, as well as surgical and medical management decisions.;   To provide this data to HCRN investigators to support hypothesis generation and study design development for clinical trials and observational studies to be carried out by the HCRN.
4 Unknown  A Study Comparing Shunt Placement Versus Endoscopic Third Ventriculostomy in the Treatment of Hydrocephalus
Condition: Hydrocephalus, Normal Pressure
Intervention: Other: Non-invasive measures
Outcome Measures: intracranial compliance;   cerebrovascular change
5 Recruiting A Study Comparing Two Treatments for Infants With Hydrocephalus
Condition: Hydrocephalus
Interventions: Procedure: Endoscopic Third Ventriculostomy;   Procedure: CSF Shunt Insertion
Outcome Measures: Health Status Outcome as measured by the Health Utilities Index - 2;   Death;   Neurodevelopment as measured by the Denver Developmental Screening Test;   Health status outcome using the Hydrocephalus Outcome Questionnaire;   In-depth Evaluation of Neurodevelopment, Functioning and Intelligence, as mesured by the Weschler Intelligence Scale for Children or Weschler Preschool and Primary Scale of Intelligence;   Number of Subsequent Hydrocephalus-Related Operations;   Surgical Morbidity;   Incidence of failure of initial intervention;   Hospitalization Time;   Need for repeat radiological scans;   Complications such as CNS infection, focal neurological deficit, significant hemorrhage, seizures requiring medication;   Ventricular size and the existence of flow void (ETV group)assessed through radiological evaluation
6 Recruiting Third Ventriculostomy Versus Shunt for Children With Hydrocephalus
Condition: Communicating Hydrocephalus
Interventions: Procedure: Endoscopic third ventriculostomy (ETV);   Procedure: Ventricular shunt
Outcome Measures: Time until need for further CSF-related surgeries;   Total number of CSF-related surgeries needed within one year
7 Recruiting Shunt Outcomes of Post-Hemorrhagic Hydrocephalus
Condition: Post-Hemorrhagic Hydrocephalus
Intervention:
Outcome Measures: Specific Aim I: Proportion of temporization;   Specific Aim 2: Conversion proportion;   Specific Aim 3: Surgery Checklist Scores;   Protocol adherence;   CSF Infection;   Neurodevelopmental Outcomes
8 Unknown  Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus
Condition: Normal Pressure Hydrocephalus
Intervention:
Outcome Measures: Neuropsychological outcome;   Mini mental state Examination;   Feasibility;   Baseline cognitive profile compared to healthy
9 Recruiting Flow MRI in Normal Pressure Hydrocephalus
Condition: Normal Pressure Hydrocephalus
Intervention: Other: Flow imaging
Outcome Measures: cerebrospinal fluid (CSF) stroke volume evolution other 6 months;   Blood flow analysis : evolution other 6 months;   Larson's score evolution over 6 months;   Neuropsychological test evolution over 6 months;   Blood flow analysis : evolution other one year;   Larson's score evolution over one year;   Neuropsychological test evolution over one year;   cerebrospinal fluid (CSF) stroke volume evolution other one year
10 Recruiting A Randomised Controlled Trial of Lumbar Drainage to Treat Communicating Hydrocephalus After Severe Intraventricular Hemorrhage
Conditions: Intracerebral Hemorrhage;   Obstructive Hydrocephalus
Intervention: Procedure: Lumbar drainage
Outcome Measures: Requirement of permanent VP-shunt;   Safety aspects;   mortality and outcome
11 Unknown  Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus
Condition: Normal Pressure Hydrocephalus
Intervention: Other: CSF collection
Outcome Measures: TGF beta-1 levels;   Mini-mental status exam;   Modified barthel index;   Tinetti mobility assessment;   Programmable shunt setting
12 Recruiting A Randomized Cross-over Study for Normal Pressure Hydrocephalus
Condition: Normal Pressure Hydrocephalus
Intervention: Device: MIETHKE proGAV® / MIETHKE proSA®
Outcome Measures: Difference in Tinetti score on optimal vs. sub optimal drainage;   Difference in Timed Up and Go (TUG) score on optimal vs. sub optimal drainage;   Difference in MCV Gait Grade on optimal vs. sub optimal drainage;   Difference in Kiefer score on optimal vs. sub optimal drainage;   Difference in Kudo score on optimal vs. sub optimal drainage
13 Unknown  Prospective Follow-up of a Multicentric Cohort of Children With Prenatal Discovery of Mild Isolated Cerebral Ventriculomegaly. Evaluation at 2 and 5 Years.
Condition: Cerebral Ventriculomegaly
Intervention:
Outcome Measure:
14 Recruiting ShuntCheck Versus Radionuclide in Evaluating Shunt Function in Symptomatic NPH Patients
Condition: Hydrocephalus
Intervention: Device: ShuntCheck test
Outcome Measure: Sensitivity and specificity of ShuntCheck vs SPS
15 Recruiting Comparison of Optic Nerve Sheath Diameter on Retrobulbar Ultrasound Before and After Drainage of Cerebrospinal Fluid in Patient With Hydrocephalus
Condition: Hydrocephalus
Intervention: Procedure: retrobulbar ultrasound
Outcome Measure: both optic nerve sheath diameter (the posterior 3mm of the papilla)
16 Recruiting Comparison of Optic Nerve Sheath Diameter on Retrobulbar Ultrasonography Before and After Drainage of Cerebrospinal Fluid in Pediatric Patient With Hydrocephalus
Condition: Hydrocephalus
Intervention: Procedure: retrobulbar ultrasound
Outcome Measure: both optic nerve sheath diameter (the posterior 3mm of the papilla)
17 Recruiting Neurocognitive Outcomes and Changes in Brain and CSF Volume After Treatment of PIH in Ugandan Infants by Shunting vs ETV/CPC
Condition: Hydrocephalus
Interventions: Device: Surgical placement of Chhabra Shunt;   Procedure: ETV/CPC
Outcome Measures: Age-normed Bayley Scales of Infant Development (BSID)-III scores;   Brain Volume;   CSF Volume
18 Recruiting Comparison of Continuous Noninvasive and Invasive Intracranial Pressure Measurement--Celda Infusion Subprotocol
Conditions: Hydrocephalus;   Shunt Malfunction
Interventions: Device: Tympanic Membrane Displacement (TMD);   Device: DPOAE
Outcome Measure: Noninvasive ICP
19 Recruiting CRT ShuntCheck "Fit & Function" Study
Condition: Hydrocephalus
Intervention: Device: Fit & Function test
Outcome Measures: Sensor fit & function;   Identify any safety issues
20 Recruiting Hypothalamic-pituitary Effects After Endoscopic Third Ventriculostomy
Condition: Obstructive Hydrocephalus
Intervention:
Outcome Measure: Variability of hypothalamic-pituitary hormones after endoscopic third ventriculostomy

These studies may lead to new treatments and are adding insight into Hydrocephalus etiology and treatment.

A major focus of Hydrocephalus research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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