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Hygroton Medical Research Studies

Up-to-date List of Hygroton Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Hygroton Medical Research Studies

Rank Status Study
1 Recruiting Efficacy/Safety Study of Valsartan and Chlorthalidone Conjugate Treatment Compared to Simple Treatment for Hypertension
Condition: Hypertension
Interventions: Drug: GROUP A: Valsartan plus Chlorthalidone;   Drug: GROUP B: Valsartan;   Drug: GROUP C: Chlorthalidone
Outcome Measures: Safety and Efficacy of the fixed-dose combination treatment with Valsartan plus Chlorthalidone;   Changes in Systolic and Diastolic Blood pressure values;   Changes of Systolic blood pressure values;   Changes of Diastolic blood pressure values;   Changes of diastolic blood pressure in arterial blood pressure median values;   Changes of systolic blood pressure values in arterial blood pressure median values;   Patient that achieving blood pressure values lower than 140/90 (systolic/diastolic) at week 6 and 12;   Patients that achieving systolic blood pressure values lower than 140 at week 6 and 12;   Patients that achieving diastolic blood pressure values lower than 90 at week 6 and 12
2 Recruiting Chlorthalidone for the Management of Resistant Hypertension in Kidney Transplant Patients
Condition: Resistant Hypertension in Kidney Transplant Patients
Intervention: Drug: Chlorthalidone
Outcome Measure: Change from mean baseline systolic blood pressure (by ABPM) between week 0, 1 and 7, ANOVA ABPM at baseline, week 1 and end of the study, Least-squares mean and standard error of the mean for changes in blood pressure measures,
3 Recruiting Drug-drug Interaction Study (Telmisartan, Amlodipine, Chlorthalidone)
Condition: Hypertension
Interventions: Drug: Telmisartan;   Drug: Amlodipine;   Drug: Chlorthalidone
Outcome Measures: AUCt ss, Cmax ss of telmisartan/amlodipine/chlorthalidone;   Cmin ss, tmax ss, t1/2 of telmisartan/amlodipine/chlorthalidone
4 Unknown  Safety and Efficacy of Chlorthalidone + Amiloride to Elderly Patients Treatment With Arterial Hypertension
Condition: Arterial Hypertension
Interventions: Drug: Chlorthalidone 25 mg + amiloride hydrochloride 5 mg;   Drug: Higroton® Laboratório Novartis
Outcome Measures: Potassium level;   Blood Pressure
5 Recruiting Chlorthalidone and HCTZ Impacts on Platelet Activation
Condition: Hypertension
Interventions: Drug: Chlorthalidone 12.5 mg;   Drug: Hydrochlorothiazide 25 mg;   Drug: Aspirin 81 mg
Outcome Measures: Change in mean fluorescence intensity of PAC-1;   Change in CD62P expression;   Change in platelet aggregation
6 Recruiting Chlorthalidone Compared to Hydrochlorothiazide on Endothelial Function
Condition: Hypertension
Interventions: Drug: Chlorthalidone 12.5 mg;   Drug: Hydrochlorothiazide 25 mg;   Drug: Placebo
Outcome Measure: Flow mediated vasodilatation
7 Not yet recruiting EBMtrialcentral- Comparing Initial Diuretic Therapies Using a Collaborative Network
Condition: Hypertension
Interventions: Drug: Chlorthalidone;   Drug: Hydrochlorothiazide
Outcome Measures: Mean systolic 24 Hour Ambulatory Blood Pressure;   Subjective Medication Side Effects
8 Recruiting Resistant Arterial Hypertension Cohort Study
Conditions: Hypertension;   Essential Hypertension;   Resistant Hypertension
Interventions: Drug: chlorthalidone;   Behavioral: motivational intervention for non-compliant individuals;   Drug: standardized anti-hypertensive treatment
Outcome Measures: blood pressure control;   cardiovascular morbidity and mortality
9 Recruiting Comparative Effectiveness of Ambulatory Blood Pressure Monitoring vs Usual Care for Diagnosing and Managing Hypertension: A Pilot Study
Condition: Hypertension
Interventions: Drug: Amlodipine;   Drug: Chlorthalidone;   Drug: Losartan
Outcome Measure: 24 hour blood pressure average at the end of 4 month participation.
10 Recruiting A Pilot Study of Chlorthalidone Among Patients With Poorly Controlled Hypertension and CKD
Conditions: Chronic Kidney Disease;   Poorly-Controlled Hypertension
Intervention: Drug: Chlorthalidone
Outcome Measure: Change of systolic ambulatory blood pressure from baseline to 12 weeks
11 Not yet recruiting Effect of Antihypertensive Agents Over Sleep Apnea
Conditions: Hypertension;   Obstructive Sleep Apnea
Interventions: Drug: Chlorthalidone/Amiloride;   Drug: Amlodipine
Outcome Measures: Apnea-Hypopnea Index;   Blood Pressure;   Adverse events;   Somnolence scale (Epworth) and ventilatory parameters;   C reactive protein
12 Recruiting Acetazolamide and Spironolactone to Increase Natriuresis in Congestive Heart Failure
Condition: Heart Failure
Interventions: Drug: Combination therapy with acetazolamide and low-dose loop diuretics;   Drug: High-dose loop diuretics;   Drug: Upfront therapy with oral spironolactone
Outcome Measures: Acetazolamide arm: natriuresis 24 h;   Spironolactone arm: incidence of hypo- (serum potassium <3.5 mmol/L) or hyperkalemia (serum potassium >5.0 mmol/L);   NT-proBNP change after 72 h;   Worsening renal function;   Persistent renal impairment;   Peak plasma aldosterone concentration after 72 h;   Peak plasma renin activity after 72 h
13 Recruiting Resistant Hypertension Optimal Treatment
Condition: Hypertension
Interventions: Drug: Spironolactone;   Drug: Clonidine
Outcome Measures: Blood pressure (mmHg);   Sympathetic nervous system and renin-angiotensin-aldosterone activity

These studies may lead to new treatments and are adding insight into Hygroton etiology and treatment.

A major focus of Hygroton research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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