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Hyperphagia Medical Research Studies

Up-to-date List of Hyperphagia Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Hyperphagia Medical Research Studies

Rank Status Study
1 Recruiting Treatment of Hyperphagia Behavioral Symptoms in Children and Adults Diagnosed With Prader-Willi Syndrome
Condition: Hyperphagia in Prader-Willi Syndrome
Interventions: Drug: FE 992097;   Drug: Placebo
Outcome Measures: Change in total Hyperphagia score as measured by a Hyperphagia for Prader-Willi Syndrome Questionnaire;   Clinical Global Impression - Improvement score;   Change in Hyperphagia for Prader-Willi Syndrome Questionnaire domain scores;   Change in Children's Yale-Brown Obsessive Compulsive Scale score;   Change in the food domain of the Reiss Profile
2 Recruiting Effects of Overfeeding Followed by Weight Loss on Liver Fat Content and Adipose Tissue Inflammation
Condition: NAFLD
Interventions: Behavioral: overeating fat;   Behavioral: overeating carbohydrate
Outcome Measures: Liver fat content (1H-MRS) and intra-abdominal and subcutaneous fat (MRI);   De novo lipogenesis (DNL) and measurement of lipolysis;   Analytical procedures
3 Recruiting Decreasing Stress and Improving Self-control With "Stress in Control" (Sync) Training
Conditions: Stress;   Obesity;   Overeating
Interventions: Behavioral: Nutritional Counseling;   Behavioral: Mindfulness Intervention
Outcome Measures: Development of treatment approaches;   Measure effectiveness of intervention
4 Recruiting The Breathe Light Study
Conditions: Over-eating;   Obesity
Interventions: Other: 20% fewer calories;   Other: 40% fewer calories
Outcome Measure: Increase in breath Carbon 13 with overconsumption of calories
5 Recruiting Clinical Study of Diazoxide Choline Controlled-Release Tablet (DCCR) in Patients With Prader-Willi Syndrome
Condition: Prader-Willi Syndrome
Interventions: Drug: DCCR;   Drug: Placebo
Outcome Measures: Hyperphagia using Hyperphagia questionnaire;   Resting energy expenditure
6 Recruiting Cognitive Processes Study in Obese Women With and Without Eating Disorders
Condition: Hyperalimentation and Obesity
Interventions: Procedure: electroencephalography;   Biological: Blood sampling;   Behavioral: Questionnaires regarding eating habits (TFEQ, EDI) and anxiety/depression (HAD)
Outcome Measures: P300 amplitude;   Auditory ERP ( latency P300, amplitude and latency of N2 wave recorded from frontal, central and parietal electrode);   assessment of dietary restraints and disinhibition;   glucose, insulin, leptin and ghrelin plasmatic rate;   dopamine D2 receptor Taq 1 polymorphism;   Dietary intake and eating patterns
7 Recruiting Learning Theory to Improve Obesity Treatment
Condition: Obesity
Interventions: Behavioral: 8 treatment sessions;   Behavioral: Cue exposure treatment (clinical trial);   Behavioral: Family-based Behavioral Treatment (FBT);   Behavioral: 16 treatment sessions;   Behavioral: Single foods;   Behavioral: Multiple foods;   Behavioral: Daily sessions;   Behavioral: Weekly sessions;   Behavioral: Partial reinforcement - Yes;   Behavioral: Partial reinforcement - No;   Behavioral: Single context;   Behavioral: Multiple contexts
Outcome Measures: Overeating (Eating in the absence of hunger);   Psychophysiological measures of responsivity to food cues;   Level of self-reported cravings in response to palatable food cues.;   Level of self-reported cravings in response to palatable food cues;   Parent and child weight change;   Child eating behaviors;   Parent feeding style;   Eating disorder behaviors and cognitions;   Treatment acceptability and preference;   Attention modification to food cues;   Impulsivity/Inhibition
8 Recruiting Predicting Weight Gain and Weight Loss Associated With Overeating or Fasting
Conditions: Obesity;   Diet Therapy;   Weight Loss;   Weight Gain;   Nutrition Therapy
Interventions: Behavioral: Nutrition Therapy;   Behavioral: Overfeeding;   Behavioral: Underfeeding
Outcome Measures: Effect of protein content on weight gain.;   Bioavailability of food; energy content of human muscle and fat tissue.
9 Recruiting Stepped Care Treatment for Binge-Eating
Condition: Binge Eating Disorder
Intervention: Behavioral: Therapy
Outcome Measure: symptom improvement
10 Recruiting Low-Dose Leptin and the Formerly-Obese
Condition: Obesity
Interventions: Drug: Leptin;   Behavioral: Dietary modification;   Drug: T3 repletion
Outcome Measure: Effects of leptin repletion on hypometabolism/Hyperphagia following weight loss
11 Not yet recruiting The Effect of a Multi-component Weight Management Program on Appetite, Food Preference and Body Weight
Conditions: Overweight;   Obesity;   Sedentary Lifestlye
Intervention: Behavioral: Weight management program
Outcome Measures: Test Meal Energy Intake;   24h Energy Intake;   Appetite sensations;   Food preference;   Body Weight
12 Recruiting REWARD SYSTEM RESPONSES TO FOOD AROMAS
Condition: Adiposity
Intervention:
Outcome Measure: neural response to food odor
13 Recruiting Stepped Care for Binge Eating Disorder: Predicting Response to Minimal Intervention in a Randomized Controlled Trial
Condition: Binge Eating Disorder
Interventions: Behavioral: Group Psychodynamic Interpersonal Psychotherapy;   Behavioral: Unguided Self-Help
Outcome Measures: Binge Eating Episodes in the Past 28 Days.;   Body Mass Index (BMI).;   Center for Epidemiologic Studies Depression Scale (CES-D);   Experiences in Close Relationships Scale (ECR);   Inventory of Interpersonal Problems (IIP-64);   Patient Health Questionnaire 9 (PHQ-9).;   Rapid Response to Treatment: Self-Monitoring;   Rosenberg Self Esteem Scale (RSES);   Eating Disorder Diagnostic Scale (EDDS);   Experiences in Close Relationships Scale Short Form (ECR-S).;   Therapeutic Factors Inventory (TFI);   Outcome Rating Scale (ORS);   Working Alliance Inventory Short (WAI-S).;   Eating Disorder Examination - Questionnaire (EDE-Q);   Depression Anxiety and Stress Scales 21(DASS-21)
14 Recruiting Prader-Willi Syndrome Macronutrient Study
Conditions: Prader Willi Syndrome;   Syndromic Obesity;   Childhood Obesity
Interventions: Other: Low Carbohydrate diet;   Other: Low Fat diet
Outcome Measures: Suppression of ghrelin;   Changes in satiety;   Improvements in insulin sensitivity
15 Recruiting Low-Dose Adjunctive Aripiprazole in the Treatment of Bipolar Depression: Double-Blind Placebo-Controlled Pilot Study
Conditions: Bipolar Disorder;   Depressive Episode
Interventions: Drug: Low dose Adjunctive Aripiprazole;   Drug: placebo
Outcome Measure: Response rate
16 Recruiting Cue Exposure Training for Overweight Children
Conditions: Overweight;   Obesity
Interventions: Behavioral: Food cue exposure;   Behavioral: Psycho-education
Outcome Measures: Eating in the absence of hunger;   Binge eating;   Cue reactivity;   Self-control and self-esteem;   Dietary restraint, and eating, weight and shape concerns;   BMI change
17 Recruiting The Secretion of Incretin Hormones in Patients With Polycystic Ovary Syndrome
Condition: Polycystic Ovary Syndrome
Intervention:
Outcome Measure: Change in incretin hormones secretion in PCOS patients.
18 Recruiting Psychological Preparation Prior to Bariatric Surgery
Conditions: Obesity;   Psychological Disorders
Intervention: Behavioral: Psychological preparation
Outcome Measures: Are there increased scores in the BAROS psychometric tests in patients that undergo psychological preparation prior to bariatric surgery, than in those that do not at 12 months?;   Are there increased scores in the EDE-Q psychometric tests in patients that undergo psychological preparation prior to bariatric surgery, than in those that do not at 12 months?;   Are there increased scores in the GAD-7 psychometric tests in patients that undergo psychological preparation prior to bariatric surgery, than in those that do not at 12 months?;   Are there increased scores in the PHQ-9 psychometric tests in patients that undergo psychological preparation prior to bariatric surgery, than in those that do not at 12 months?
19 Not yet recruiting Weight-loss and Gut-brain Interactions
Condition: Obesity
Interventions: Dietary Supplement: Very Low Calorie Diet (VLCD);   Procedure: RYGB;   Procedure: LAGB
Outcome Measures: the optimal interaction of gut hormones and brain activity;   gut-microbiota;   body composition;   endocannabinoid profile;   Diet induced energy expenditure
20 Recruiting Effects of Diet Changes on Metabolism
Condition: Obesity
Intervention:
Outcome Measure:

These studies may lead to new treatments and are adding insight into Hyperphagia etiology and treatment.

A major focus of Hyperphagia research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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