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Hypertrophic Medical Research Studies

Up-to-date List of Hypertrophic Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Hypertrophic Medical Research Studies

Rank Status Study
1 Recruiting HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy
Condition: Hypertrophic Cardiomyopathy
Intervention: Other: None - this is an observational study
Outcome Measures: Cardiac death;   Aborted sudden cardiac death;   Heart transplantation;   left ventricular assist device placement;   All-cause mortality;   Ventricular tachyarrhythmias;   Hospitalization for heart failure;   Atrial fibrillation;   Stroke
2 Unknown  Effects of Continous Positive Airway Pressure (CPAP) in Hypertrophic Cardiomyopathy
Conditions: Non-obstructive Hypertrophic Cardiomyopathy;   Obstructive Hypertrophic Cardiomyopathy
Intervention: Device: CPAP
Outcome Measure: Cadiac performance by echocardiography
3 Recruiting Surgical Treatment of Hypertrophic Obstructive Cardiomyopathy With Severe Mitral Insufficiency.
Condition: Hypertrophic Obstructive Cardiomyopathy
Interventions: Procedure: myoectomy;   Procedure: Mitral valve surgery
Outcome Measures: The function of the mitral valve (mitral regurgitation return, prosthesis dysfunction);   The pressure gradient in the output section of the left ventricle
4 Unknown  Biventricular Pacing in Hypertrophic Cardiomyopathy
Condition: Hypertrophic Cardiomyopathy
Intervention: Device: Biventricular Pacemaker
Outcome Measures: Peak Exercise Oxygen Consumption.;   Myocardial Asynchrony Index;   Minnesota Quality of Life Questionnaire
5 Recruiting Study of Exercise Training in Hypertrophic Cardiomyopathy
Condition: Cardiomyopathy, Hypertrophic
Intervention: Behavioral: Exercise training
Outcome Measures: Change in peak oxygen consumption;   Magnitude or distribution of cardiac hypertrophy or left ventricular dimensions.;   Degree of left ventricular outflow obstruction.;   Systolic or diastolic function.;   Scar volume by MRI;   Stretch activation markers.;   Quality of life indicators.
6 Recruiting Biventricular Pacing in Hypertrophic Cardiomyopathy After Aortic Valve Replacement
Condition: Hypertrophic Cardiomyopathy
Intervention: Procedure: additional temporary pacewire
Outcome Measure: Cardiac output
7 Recruiting French Hypertrophic Cardiomyopathy Observatory
Condition: Hypertrophic Cardiomyopathy
Intervention:
Outcome Measures: Event-free survival;   Diagnostic methods
8 Unknown  Clinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy
Conditions: Myocardial Fibrosis;   Hypertrophic Cardiomyopathy
Intervention: Drug: spironolactone
Outcome Measures: changes in serum markers of collagen turnover;   measures of diastolic function by echocardiography;   cardiac mass and fibrosis by cardiac magnetic resonance imaging (CMR);   exercise tolerance by exercise VO2max and Holter
9 Recruiting To Study Gene Expression of Postburn Hypertrophic Scar
Condition: Cicatrix, Hypertrophic
Intervention:
Outcome Measure:
10 Recruiting Prevalence of Transthyretin Amyloidosis in Hypertrophic Cardiomyopathy
Conditions: Cardiac Amyloidosis;   Amyloidosis in Transthyretin (TTR);   Hypertrophic Cardiomyopathy (HCM)
Intervention:
Outcome Measures: Number of ATTRm mutations;   Genotype and clinical factors
11 Unknown  A Biomarker and MRI Study on Troponin Release After Exercise in Hypertrophic Cardiomyopathy
Condition: Hypertrophic Cardiomyopathy
Intervention:
Outcome Measures: Troponin levels at baseline and troponin rise after exercise testing using a high sensitivity-troponin (hs-troponin) assay;   Correlation between troponin levels and phenotypic characteristics assessed with MRI (LV volumes, mass and ejection fraction, presence of LGE and/or elevated signal on T2-weighted imaging)
12 Unknown  Comparison of Data Obtained by Echocardiography and Magnetic Resonance Imaging in Hypertrophic Cardiomyopathy
Condition: Hypertrophic Cardiomyopathy
Intervention:
Outcome Measure:
13 Recruiting A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Scar Revision Surgery in Healthy Adults
Condition: Hypertrophic Scar
Interventions: Drug: RXI-109;   Drug: Placebo
Outcome Measures: Reduction in recurrence of Hypertrophic scarring after scar revision surgery;   Safety of RXI-109
14 Unknown  Diastolic Ventricular Interaction and the Effects of Biventricular Pacing in Hypertrophic Cardiomyopathy
Condition: Hypertrophic Cardiomyopathy
Intervention: Device: Cardiac Resynchronisation Therapy
Outcome Measure:
15 Unknown  Exercise Study Including Patients With Hypertrophic Cardiomyopathy
Condition: Cardiomyopathy, Hypertrophic
Intervention: Behavioral: stop exercising
Outcome Measures: Improvement in ability to perform activities and tasks.;   Improvement in heart size and function and quality of life (QOL).
16 Unknown  Trimetazidine Therapy in Hypertrophic Cardiomyopathy
Condition: Hypertrophic Cardiomyopathy
Interventions: Drug: Trimetazidine;   Other: Placebo capsule
Outcome Measures: Peak oxygen consumption;   Left ventricular function;   Symptom status;   Arrhythmia;   Cardiac biomarkers;   Exercise capacity
17 Unknown  Exercise Training in Patients With Hypertrophic Cardiomyopathy
Condition: Hypertrophic Cardiomyopathy
Intervention: Behavioral: Exercise Training
Outcome Measures: Functional capacity improvement as determined by the degree of percent change in VO2 MAX following structured exercise rehabilitation;   Safety of exercise training in patients with symptomatic Hypertrophic cardiomyopathy;   Secondary Endpoints:
18 Unknown  The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in Childhood
Conditions: Healthy;   Hypertrophic Pyloric Stenosis
Intervention: Behavioral: sodium taste tests
Outcome Measure: Increased sodium intake
19 Not yet recruiting Triple Chamber Pacing in Hypertrophic Obstructive Cardiomyopathy (HOCM) Patients - TRICHAMPION STUDY
Condition: Hypertrophic Cardiomyopathy With Obstruction
Intervention: Device: CRT-P Implant
Outcome Measure: To evaluate the percentage of HOCM patients with severe LVOT obstruction implanted with a CRT-P device that have symptomatic improvement at 12 months.
20 Not yet recruiting CArdiac Desynchronization In Obstructive HCM, CARDIO-HCM
Condition: Hypertrophic Obstructive Cardiomyopathy (HOCM)
Interventions: Device: Biventricular pacing;   Device: No Pacing
Outcome Measures: Change from Baseline in Left ventricular mass and resting left ventricular outflow tract gradient (mmHg).;   Change from Baseline in Clinical evaluation of NYHA,QoL,6MWT,interventricular septum thickness,posterior wall thickness,provoked left ventricular outflow tract gradient,mitral regurgitation grade.

These studies may lead to new treatments and are adding insight into Hypertrophic etiology and treatment.

A major focus of Hypertrophic research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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